{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:17:46Z","timestamp":1789888666340,"version":"4.0.1"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,6,29]]},"abstract":"<jats:p>Background: Subjective cognitive decline (SCD) is associated with increased risk of developing Alzheimer\u2019s disease (AD). However, the underlying mechanisms for this association remain unclear. Neuroimaging studies suggest the earliest AD-related changes are large-scale network disruptions, beginning in the posterior default mode (pDMN) network. Objective: To examine the association between SCD and pDMN network connectivity with medial temporal lobe (MTL) regions using resting-state functional magnetic resonance imaging. Methods: Forty-nine participants with either SCD (n\u200a=\u200a23, 12 females; mean age: 70.7 (5.5)) or who were cognitively unimpaired (CU; n\u200a=\u200a26, 16 females, mean age: 71.42 (7.3)) completed the Memory Functioning Questionnaire, a measure of subjective memory, and underwent resting state functional MRI at 3 Tesla. Functional connectivity between the posterior cingulate cortex (PCC), as the key pDMN node, and MTL regions were compared between SCD and CU groups. Further, the association between pDMN-MTL connectivity and the Frequency of Forgetting subscale of the Memory Functioning Questionnaire was examined. Results: Connectivity between the PCC-MTL was observed in the CU group but was absent in SCD (t(47)\u200a=\u200a2.69, p\u200a=\u200a0.01). Across all participants, self-perception of frequency of forgetting, but not objective memory, was strongly correlated with connectivity between the PCC-left parahippocampal gyrus (r\u200a=\u200a0.43, p\u200a=\u200a0.002). Conclusion: These findings support the hypothesis that increased AD risk in SCD may be mediated by disrupted pDMN-parahippocampal connectivity. In addition, these findings suggest that frequency of forgetting may serve as a potential biomarker of SCD due to incipient AD.<\/jats:p>","DOI":"10.3233\/jad-201579","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T13:52:22Z","timestamp":1621345942000},"page":"435-445","source":"Crossref","is-referenced-by-count":23,"title":["Functional Connectivity Between the Posterior Default Mode Network and Parahippocampal Gyrus Is Disrupted in Older Adults with Subjective Cognitive Decline and Correlates with Subjective Memory Ability"],"prefix":"10.1177","volume":"82","author":[{"given":"Namita","family":"Sharma","sequence":"first","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetanjali","family":"Murari","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Vandermorris","sequence":"additional","affiliation":[{"name":"Baycrest Health Sciences, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas Paul L.G.","family":"Verhoeff","sequence":"additional","affiliation":[{"name":"Baycrest Health Sciences, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, Geriatric Psychiatry Division, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, Geriatric Psychiatry Division, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Jean","family":"Chen","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada"},{"name":"Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Mah","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, Geriatric Psychiatry Division, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-201579_ref1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1474-4422(19)30368-0","article-title":"The characterisation of subjective cognitive decline","volume":"19","author":"Jessen","year":"2020","journal-title":"Lancet 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