{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:58:07Z","timestamp":1777395487535,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:p>Background: Migraine is known to mildly increase the risk for ischemic stroke and is associated with vascular MRI markers. However, the potential effect of chronic headache (CH) on stroke outcomes has not been studied. Objective: We aimed to assess the interrelation between CH and post-stroke cognitive impairment. Methods: Data from 455 patients with a first ever stroke from the TABASCO study was available. All patients underwent 3T brain MRI, blood analysis, and a serial cognitive assessment at baseline and 6, 12, and 24 months after. Results: Eighty-five (18.7%) patients reported suffering from CH, of whom 53 (62.4%) reported symptoms of photophobia or nausea, and 34 (40%) reported an aura. CH was associated with female sex, lower prevalence of T2DM (p\u200a&lt;\u200a0.001), and lower HbA1C levels (p\u200a&lt;\u200a0.001). Multiple regression analysis, controlling for age, sex, education, vascular risk factors, and the presence of acute lesions in MRI, revealed that CH was an independent predictor of better cognitive scores 6, 12, and 24 months post-stroke (p\u200a=\u200a0.015, p\u200a=\u200a0.01, and p\u200a=\u200a0.012, respectively). Stroke patients suffering from CH had also higher normalized gray, white matter, and thalamus volumes, and better white matter microstructural integrity (p\u200a&lt;\u200a0.001, p\u200a=\u200a0.037, p\u200a&lt;\u200a0.001, p\u200a=\u200a0.008, respectively) Conclusion: In this study, CH was consistently associated with better long term cognitive scores among post stroke subjects. These surprising findings may partially arise from the higher prevalence of T2DM among subjects without CH, that may represent the existence of chronic cerebrovascular disease, and may reflect mechanisms involving glucose metabolism.<\/jats:p>","DOI":"10.3233\/jad-210077","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T05:25:35Z","timestamp":1620192335000},"page":"1555-1566","source":"Crossref","is-referenced-by-count":2,"title":["The Interrelation Between Chronic Headache, Cognitive Scores, and MRI Markers Among Stroke Survivors"],"prefix":"10.1177","volume":"81","author":[{"given":"Jeremy","family":"Molad","sequence":"first","affiliation":[{"name":"Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hen","family":"Hallevi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel"},{"name":"Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos D.","family":"Korczyn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estelle","family":"Seyman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natan M.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shaare-Zedek Medical Center, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Niry","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Eldor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Diabetes Unit, Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einor","family":"Ben Assayag","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel"},{"name":"Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210077_ref1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/bmj.38302.504063.8F","article-title":"Risk of ischaemic stroke in people with migraine: Systematic review and meta-analysis of observational studies","volume":"330","author":"Etminan","year":"2005","journal-title":"BMJ"},{"key":"10.3233\/JAD-210077_ref2","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1093\/brain\/awx223","article-title":"Migraine and risk of stroke: A national population-based twin study","volume":"140","author":"Lantz","year":"2017","journal-title":"Brain"},{"key":"10.3233\/JAD-210077_ref3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10072-016-2746-z","article-title":"Migraine and the risk of stroke: An updated meta-analysis of prospective cohort studies","volume":"38","author":"Hu","year":"2017","journal-title":"Neurol Sci"},{"key":"10.3233\/JAD-210077_ref4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10072-018-3429-8","article-title":"Migraine and cerebrovascular disease: Still a dangerous connetction?","volume":"39","author":"Agostoni","year":"2018","journal-title":"Neurol Sci"},{"key":"10.3233\/JAD-210077_ref5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s10194-017-0815-1","article-title":"Hormonal contraceptives and risk of ischemic stroke in women with migraine: A consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)","volume":"18","author":"Sacco","year":"2017","journal-title":"J Headache Pain"},{"key":"10.3233\/JAD-210077_ref6","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.neuron.2015.04.004","article-title":"The stroke-migraine depolarization continuum","volume":"86","author":"Dreier","year":"2015","journal-title":"Neuron"},{"key":"10.3233\/JAD-210077_ref7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11910-017-0729-y","article-title":"Migraine and stroke: What\u2019s the link? 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