{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:32:38Z","timestamp":1790850758884,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:p>Background: MIND diet, a hybrid of the Mediterranean diet and the Dietary Approaches to Stop Hypertension diet, is associated with a slower cognitive decline and lower risk of Alzheimer\u2019s disease (AD) dementia in older adults. Objective: We aim to examine whether the association of the MIND diet with cognition is independent of common brain pathologies. Methods: Utilizing data from the Rush Memory and Aging Project (MAP), a longitudinal clinical-pathologic study, we studied 569 decedents with valid dietary data, cognitive testing proximate to death, and complete autopsy data at the time of these analyses. A series of regression analyses were used to examine associations of the MIND diet, dementia-related brain pathologies, and global cognition proximate to death adjusting for age, sex, education, APOE \u025b4, late-life cognitive activities, and total energy intake. Results: A higher MIND diet score was associated with better global cognitive functioning proximate to death (\u03b2=\u200a0.119, SE\u200a=\u200a0.040, p\u200a=\u200a0.003), and neither the strength nor the significance of association changed substantially when AD pathology and other brain pathologies were included in the model. The \u03b2-estimate after controlling for global AD pathology was 0.111 (SE\u200a=\u200a0.037, p\u200a=\u200a0.003). The MIND diet-cognition relationship remained significant when we restricted our analysis to individuals without mild cognitive impairment at the baseline (\u03b2=\u200a0.121, SE\u200a=\u200a0.042, p\u200a=\u200a0.005) or in people diagnosed with postmortem diagnosis of AD based on NIA-Reagan consensus recommendations (\u03b2=\u200a0.114, SE\u200a=\u200a0.050, p\u200a=\u200a0.023). Conclusion: MIND diet is associated with better cognitive functioning independently of common brain pathology, suggesting that the MIND diet may contribute to cognitive resilience in the elderly.<\/jats:p>","DOI":"10.3233\/jad-210107","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:14:32Z","timestamp":1627391672000},"page":"683-692","source":"Crossref","is-referenced-by-count":90,"title":["MIND Diet, Common Brain Pathologies, and Cognition in Community-Dwelling Older Adults"],"prefix":"10.1177","volume":"83","author":[{"given":"Klodian","family":"Dhana","sequence":"first","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan D.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA"},{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelum T.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel J.","family":"Cherian","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue E.","family":"Leurgans","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Pathology, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210107_ref1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer\u2019s 1907 paper, \u201cuber eine eigenartige erkankung der hirnrinde\"","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin Anat"},{"key":"10.3233\/JAD-210107_ref2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/nm1067","article-title":"Molecular pathways to neurodegeneration","volume":"10 Suppl","author":"Bossy-Wetzel","year":"2004","journal-title":"Nat Med"},{"key":"10.3233\/JAD-210107_ref3","doi-asserted-by":"crossref","first-page":"17401","DOI":"10.1074\/jbc.M300629200","article-title":"Structure of the Alzheimer\u2019s disease amyloid precursor protein copper binding domain. 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