{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:58:51Z","timestamp":1777395531822,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,6,29]]},"abstract":"<jats:p>Background: The Memory Associative Test TMA-93 examines visual relational binding, characteristically affected in early-AD stages. Objective: We aim to validate the TMA-93 by biomarkers determination and compare its diagnostic characteristics with the Free and Cued Selective Reminding Test (FCSRT). Methods: Retrospective analysis of a Biobank database. Patients\u2019 records initially consulted for memory complaints, scored MMSE\u226522, had TMA-93 and FCSRT tested, and AD biomarker determination (Amyloid-PET or CSF), either positive or negative, were selected. As cutoffs, we considered the 10-percentile for TMA-93 (P10\/TMA-93), and \u201ctotal free recall\u201d (TFR) 21\/22, total recall (TR) 43\/44, and Cued Index &lt;\u200a0.77 for FCSRT from previous Spanish validation and normative studies. Diagnostic utilities were calculated using ROC curves and compared by the DeLong method. We studied if one test improved the other test\u2019s prediction, following a forward stepwise logistic regression model. Results: We selected 105 records: 64 \u201cpositive\u201d and 41 \u201cnegative\u201d biomarkers. TMA-93 total score diagnostic utility (AUC\u200a=\u200a0.72; 95%CI:0.62\u20130.82) was higher than those of the FCSRT: TFR (AUC\u200a=\u200a0.70; 95%CI: 0.60\u20130.80), TR (AUC\u200a=\u200a0.63; 95%CI:0.53\u20130.74), and Cued Index (AUC\u200a=\u200a0.62; 95%CI:0.52\u20130.73). The P10\/TMA-93 cutoff showed 86%sensitivity, similar to that of the most sensitive FCSRT cutoff (TFR21\/22, 89%) and 29%specificity, lower than that of the most specific FCSRT cutoff (Cued Index\u200a&lt;\u200a0.77, 57%). 32.8%of the positive-biomarker group scored above CI\/0.77 but below p10TMA-93. The addition of TMA-93 total score to FCSRT variables improved significantly the biomarkers results\u2019 prediction. Conclusion: TMA-93 demonstrated \u201creasonable\u201d diagnostic utility, similar to FCSRT, for discriminating AD biomarker groups. TMA-93 total score improved the AD biomarker result prediction when added to FCSRT variables.<\/jats:p>","DOI":"10.3233\/jad-210115","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T13:21:44Z","timestamp":1621603304000},"page":"401-410","source":"Crossref","is-referenced-by-count":9,"title":["TMA-93 Validation by Alzheimer\u2019s Disease Biomarkers: A Comparison with the Free and Cued Selective Reminding Test on a Biobank Sample"],"prefix":"10.1177","volume":"82","author":[{"given":"Silvia","family":"Rodrigo-Herrero","sequence":"first","affiliation":[{"name":"Memory Unit, Juan Ram\u00f3n Jim\u00e9nez University Hospital, Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Luque-Tirado","sequence":"additional","affiliation":[{"name":"Memory Unit, Virgen del Rocio University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlota","family":"M\u00e9ndez-Barrio","sequence":"additional","affiliation":[{"name":"Memory Unit, Juan Ram\u00f3n Jim\u00e9nez University Hospital, Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Garc\u00eda-Sol\u00eds","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Virgen del Rocio University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Bernal S\u00e1nchez-Arjona","sequence":"additional","affiliation":[{"name":"Memory Unit, Virgen del Rocio University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Oropesa-Ruiz","sequence":"additional","affiliation":[{"name":"Memory Unit, Juan Ram\u00f3n Jim\u00e9nez University Hospital, Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Maillet","sequence":"additional","affiliation":[{"name":"Neurology Service, Saint-Louis Hospital (AP-HP), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Franco-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Memory Unit, Virgen del Rocio University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210115_ref1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","article-title":"Introduction to the recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimers 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