{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:23:33Z","timestamp":1785803013546,"version":"3.56.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,8,17]]},"abstract":"<jats:p>The present study reports two novel genome-wide significant loci for late-onset Alzheimer\u2019s disease (LOAD) identified from APOE \u03b54 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer\u2019s disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer\u2019 and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.<\/jats:p>","DOI":"10.3233\/jad-210145","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T14:46:28Z","timestamp":1624027588000},"page":"1451-1460","source":"Crossref","is-referenced-by-count":36,"title":["Potential Novel Genes for Late-Onset Alzheimer\u2019s Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study"],"prefix":"10.1177","volume":"82","author":[{"given":"Sarang","family":"Kang","sequence":"first","affiliation":[{"name":"Gwangju Alzheimer\u2019s & Related Dementias Cohort Research Center, Chosun University, Gwangju, Republic of Korea"},{"name":"Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of 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