{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:20:31Z","timestamp":1788477631087,"version":"build-2803163510"},"reference-count":59,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,8,17]]},"abstract":"<jats:p>Background: Preventing Loss of Independence through Exercise (PLI\u00c9) is a group movement program initially developed for people with mild-to-moderate dementia that integrates principles from several well-established traditions to specifically address the needs of people with cognitive impairment. Objective: To investigate whether PLI\u00c9 would benefit cognitive and behavioral outcomes and functional brain connectivity in older adults with milder forms of cognitive impairment. Methods: Participants (\u226555 y) with subjective memory decline (SMD) or mild cognitive impairment (MCI) were assessed with tests of cognitive and physical function, self-report questionnaires, and resting state functional magnetic resonance imaging (rs-fMRI) on a 3 Tesla scanner before and after participating in twice weekly PLI\u00c9 classes for 12 weeks at the San Francisco Veterans Affairs Medical Center. Results: Eighteen participants completed the pre-post intervention pilot trial. We observed significant improvements on the Alzheimer\u2019s Disease Assessment Scale cognitive subscale (ADAS-cog; effect size 0.34, p\u200a=\u200a0.002) and enhanced functional connections between the medial prefrontal cortex (mPFC) and other nodes of the default mode network (DMN) after PLI\u00c9. Improvements (i.e., lower scores) on ADAS-cog were significantly correlated with enhanced functional connectivity between the mPFC and left lateral parietal cortex (Spearman\u2019s \u03c1=\u200a\u20130.74, p\u200a=\u200a0.001) and between the mPFC and right hippocampus (Spearman\u2019s \u03c1=\u200a\u20130.83, p\u200a=\u200a0.001). After completing PLI\u00c9, participants reported significant reductions in feelings of social isolation and improvements in well-being and interoceptive self-regulation. Conclusion: These preliminary findings of post-PLI\u00c9 improvements in DMN functional connectivity, cognition, interoceptive self-regulation, well-being and reduced feelings of social isolation warrant larger randomized, controlled trials of PLI\u00c9 in older adults with SMD and MCI.<\/jats:p>","DOI":"10.3233\/jad-210159","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T14:39:08Z","timestamp":1624372748000},"page":"1543-1557","source":"Crossref","is-referenced-by-count":14,"title":["Preventing Loss of Independence through Exercise (PLI\u00c9): A Pilot Trial in Older Adults with Subjective Memory Decline and Mild Cognitive Impairment"],"prefix":"10.1177","volume":"82","author":[{"given":"Linda L.","family":"Chao","sequence":"first","affiliation":[{"name":"San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA"},{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Lee","sequence":"additional","affiliation":[{"name":"San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Martinez","sequence":"additional","affiliation":[{"name":"San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Barlow","sequence":"additional","affiliation":[{"name":"San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Chesney","sequence":"additional","affiliation":[{"name":"Osher Center for Integrative Medicine, University of California, San Francisco, CA, USA"},{"name":"Department of Medicine, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf E.","family":"Mehling","sequence":"additional","affiliation":[{"name":"Osher Center for Integrative Medicine, University of California, San Francisco, CA, USA"},{"name":"Department of Family and Community Medicine, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah E.","family":"Barnes","sequence":"additional","affiliation":[{"name":"San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA"},{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210159_ref1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/13607863.2010.543665","article-title":"Psychosocial interventions in dementia care research: The INTERDEM manifesto","volume":"15","author":"Moniz-Cook","year":"2011","journal-title":"Aging Ment Health"},{"key":"10.3233\/JAD-210159_ref2","unstructured":"Institute of Medicine. 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