{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:34:33Z","timestamp":1789497273190,"version":"build-2803163510"},"reference-count":99,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:p>Background: Social cognition is critically compromised across neurodegenerative diseases, including the behavioral variant frontotemporal dementia (bvFTD), Alzheimer\u2019s disease (AD), and Parkinson\u2019s disease (PD). However, no previous study has used social cognition and other cognitive tasks to predict diagnoses of these conditions, let alone reporting the brain correlates of prediction outcomes. Objective: We performed a diagnostic classification analysis using social cognition, cognitive screening (CS), and executive function (EF) measures, and explored which anatomical and functional networks were associated with main predictors. Methods: Multiple group discriminant function analyses (MDAs) and ROC analyses of social cognition (facial emotional recognition, theory of mind), CS, and EF were implemented in 223 participants (bvFTD, AD, PD, controls). Gray matter volume and functional connectivity correlates of top discriminant scores were investigated. Results: Although all patient groups revealed deficits in social cognition, CS, and EF, our classification approach provided robust discriminatory characterizations. Regarding controls, probabilistic social cognition outcomes provided the best characterization for bvFTD (together with CS) and PD, but not AD (for which CS alone was the best predictor). Within patient groups, the best MDA probabilities scores yielded high classification rates for bvFTD versus PD (98.3%, social cognition), AD versus PD (98.6%, social cognition\u200a+\u200aCS), and bvFTD versus AD (71.7%, social cognition\u200a+\u200aCS). Top MDA scores were associated with specific patterns of atrophy and functional networks across neurodegenerative conditions. Conclusion: Standardized validated measures of social cognition, in combination with CS, can provide a dimensional classification with specific pathophysiological markers of neurodegeneration diagnoses.<\/jats:p>","DOI":"10.3233\/jad-210163","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T10:21:00Z","timestamp":1626430860000},"page":"227-248","source":"Crossref","is-referenced-by-count":23,"title":["Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes"],"prefix":"10.1177","volume":"83","author":[{"given":"Agust\u00edn","family":"Iba\u00f1ez","sequence":"first","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile"},{"name":"Cognitive Neuroscience Center (CNC), Universidad de San Andr\u00e9s, Buenos Aires, Argentina"},{"name":"National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"},{"name":"Global Brain Health Institute, University of California, San Francisco, CA, USA"},{"name":"Global Brain Health Institute, Trinity College Dublin (TCD), Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Fittipaldi","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center (CNC), Universidad de San Andr\u00e9s, Buenos Aires, Argentina"},{"name":"National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"},{"name":"Facultad de Psicolog\u00eda, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Trujillo","sequence":"additional","affiliation":[{"name":"Instituto de Psicolog\u00eda, Universidad del Valle, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Instituto de Psicolog\u00eda, Universidad del Valle, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Torres","sequence":"additional","affiliation":[{"name":"Instituto de Psicolog\u00eda, Universidad del Valle, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Cardona","sequence":"additional","affiliation":[{"name":"Instituto de Psicolog\u00eda, Universidad del Valle, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Rivera","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Instituto de Neurocirugia, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Slachevsky","sequence":"additional","affiliation":[{"name":"Geroscience Center for Brain Health and Metabolism (GERO), Faculty of Medicine, University of Chile, Santiago, Chile"},{"name":"Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department - ICBM, Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center (CNC), Universidad de San Andr\u00e9s, Buenos Aires, Argentina"},{"name":"National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"},{"name":"Global Brain Health Institute, University of California, San Francisco, CA, USA"},{"name":"Departamento de Ling\u00fc\u00edstica y Literatura, Facultad de Humanidades, Universidad de Santiago de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Bertoux","sequence":"additional","affiliation":[{"name":"Lille Center of Excellence for Neurodegenerative Disorders (LICEND), CHU Lille, U1172 - Lille Neurosciences & Cognition, Universit\u00e9 de Lille, Inserm, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Baez","sequence":"additional","affiliation":[{"name":"Universidad de los Andes, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210163_ref1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/jnnp-2014-309445","article-title":"Theory of mind in behavioural-variant frontotemporal dementia and Alzheimer\u2019s disease: A meta-analysis","volume":"86","author":"Bora","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210163_ref2","first-page":"e15","article-title":"Reply: Towards a neurocomputational account of social dysfunction in neurodegenerative disease","volume":"140","author":"Ib\u00e1\u00f1ez","year":"2017","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neubiorev.2017.11.014","article-title":"Social cognitive dysfunction as a clinical marker: A systematic review of meta-analyses across 30 clinical conditions","volume":"84","author":"Cotter","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-210163_ref4","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.jalz.2012.09.010","article-title":"Sensitivity and specificity of ventromedial prefrontal cortex tests in behavioral variant frontotemporal dementia","volume":"9","author":"Bertoux","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210163_ref5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13195-017-0287-1","article-title":"Can cognitive assessment really discriminate early stages of Alzheimer\u2019s and behavioural variant frontotemporal dementia at initial clinical presentation?","volume":"9","author":"Reul","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-210163_ref6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cortex.2017.05.022","article-title":"Assessing the \u201csocial brain\u201d in dementia: Applying TASIT-S","volume":"93","author":"Kumfor","year":"2017","journal-title":"Cortex"},{"key":"10.3233\/JAD-210163_ref7","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1093\/brain\/awy233","article-title":"Brain oscillations, inhibition and social inappropriateness in frontotemporal degeneration","volume":"141","author":"Ib\u00e1\u00f1ez","year":"2018","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref8","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1523\/JNEUROSCI.2578-20.2021","article-title":"Interoception primes emotional processing: Multimodal evidence from neurodegeneration","volume":"41","author":"Salamone","year":"2021","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-210163_ref9","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3233\/JAD-150686","article-title":"Social cognition deficits: The key to discriminate behavioral variant frontotemporal dementia from Alzheimer\u2019s disease regardless of amnesia?","volume":"49","author":"Bertoux","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210163_ref10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1037\/a0025318","article-title":"The SEA (Social cognition and Emotional Assessment): A clinical neuropsychological tool for early diagnosis of frontal variant of frontotemporal lobar degeneration","volume":"26","author":"Funkiewiez","year":"2012","journal-title":"Neuropsychology"},{"key":"10.3233\/JAD-210163_ref11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jagp.2016.06.011","article-title":"Dissociation in rating negative facial emotions between behavioral variant frontotemporal dementia and major depressive disorder","volume":"24","author":"Chiu","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-210163_ref12","doi-asserted-by":"crossref","first-page":"e0143586","DOI":"10.1371\/journal.pone.0143586","article-title":"Neuroanatomical correlates of recognizing face expressions in mild stages of Alzheimer\u2019s disease","volume":"10","author":"Sapey-Triomphe","year":"2015","journal-title":"PLoS One"},{"key":"10.3233\/JAD-210163_ref13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/psyg.12533","article-title":"Sally-Anne test and regional cerebral blood flow in Alzheimer\u2019s disease dementia","volume":"20","author":"Takenoshita","year":"2020","journal-title":"Psychogeriatrics"},{"key":"10.3233\/JAD-210163_ref14","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/mds.27305","article-title":"Facial emotion recognition in Parkinson\u2019s disease: A review and new hypotheses","volume":"33","author":"Argaud","year":"2018","journal-title":"Mov Disord"},{"key":"10.3233\/JAD-210163_ref15","doi-asserted-by":"crossref","first-page":"e0142234","DOI":"10.1371\/journal.pone.0142234","article-title":"Neuroanatomical correlates of theory of mind deficit in Parkinson\u2019s disease: A multimodal imaging study","volume":"10","author":"D\u00edez-Cirarda","year":"2015","journal-title":"PLoS One"},{"key":"10.3233\/JAD-210163_ref16","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.neuropsychologia.2012.05.020","article-title":"Structural correlates of facial emotion recognition deficits in Parkinson\u2019s disease patients","volume":"50","author":"Baggio","year":"2012","journal-title":"Neuropsychologia"},{"key":"10.3233\/JAD-210163_ref17","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3389\/fnins.2019.01259","article-title":"Association between social cognition changes and resting state functional connectivity in frontotemporal dementia, Alzheimer\u2019s disease, Parkinson\u2019s disease, and healthy controls","volume":"13","author":"Multani","year":"2019","journal-title":"Front Neurosci"},{"key":"10.3233\/JAD-210163_ref18","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3389\/fneur.2017.00682","article-title":"Impaired emotional mirroring in Parkinson\u2019s disease-A study on brain activation during processing of facial expressions","volume":"8","author":"Pohl","year":"2017","journal-title":"Front Neurol"},{"issue":"s1","key":"10.3233\/JAD-210163_ref19","doi-asserted-by":"crossref","first-page":"S379","DOI":"10.3233\/JAD-201384","article-title":"The Latin America and the Caribbean Consortium on Dementia (LAC-CD): From networking to research to implementation science","volume":"82","author":"Ibanez","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210163_ref20","doi-asserted-by":"crossref","first-page":"631722","DOI":"10.3389\/fneur.2021.631722","article-title":"The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving multicentric research and implementation science","volume":"12","author":"Ibanez","year":"2021","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-210163_ref21","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.dadm.2019.06.002","article-title":"Robust automated computational approach for classifying frontotemporal neurodegeneration: Multimodal\/multicenter neuroimaging","volume":"11","author":"Donnelly-Kehoe","year":"2019","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.3233\/JAD-210163_ref22","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1002\/hbm.23627","article-title":"Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia","volume":"38","author":"Sedeno","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-210163_ref23","doi-asserted-by":"crossref","first-page":"11181","DOI":"10.1038\/s41598-018-29538-9","article-title":"Weighted Symbolic Dependence Metric (wSDM) for fMRI resting-state connectivity: A multicentric validation for frontotemporal dementia","volume":"8","author":"Moguilner","year":"2018","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-210163_ref24","doi-asserted-by":"crossref","first-page":"117522","DOI":"10.1016\/j.neuroimage.2020.117522","article-title":"Dynamic brain fluctuations outperform connectivity measures and mirror pathophysiological profiles across dementia subtypes: A multicenter study","volume":"225","author":"Moguilner","year":"2021","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210163_ref25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cortex.2020.12.023","article-title":"Metacognition of emotion recognition across neurodegenerative diseases","volume":"137","author":"Garcia-Cordero","year":"2021","journal-title":"Cortex"},{"key":"10.3233\/JAD-210163_ref26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-210163_ref27","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1017\/S1355617709990415","article-title":"INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia","volume":"15","author":"Torralva","year":"2009","journal-title":"J Int Neuropsychol Soc"},{"key":"10.3233\/JAD-210163_ref28","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1212\/WNL.0b013e3181fc29c9","article-title":"The MoCA: Well-suited screen for cognitive impairment in Parkinson disease","volume":"75","author":"Dalrymple-Alford","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-210163_ref29","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.parkreldis.2014.08.002","article-title":"Montreal Cognitive Assessment for the screening and prediction of cognitive decline in early Parkinson\u2019s disease","volume":"20","author":"Kandiah","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"10.3233\/JAD-210163_ref30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1532-5415.2008.02096.x","article-title":"Montreal cognitive assessment performance in patients with Parkinson\u2019s disease with \u201cnormal\u201d global cognition according to mini-mental state examination score","volume":"57","author":"Nazem","year":"2009","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-210163_ref31","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1093\/brain\/awx269","article-title":"A lesion model of envy and Schadenfreude: Legal, deservingness and moral dimensions as revealed by neurodegeneration","volume":"140","author":"Santamar\u00eda-Garc\u00eda","year":"2017","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.psychres.2014.01.020","article-title":"The utility of IFS (INECO Frontal Screening) for the detection of executive dysfunction in adults with bipolar disorder and ADHD","volume":"216","author":"Baez","year":"2014","journal-title":"Psychiatry Res"},{"key":"10.3233\/JAD-210163_ref33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cortex.2015.05.022","article-title":"Syntax, action verbs, action semantics, and object semantics in Parkinson\u2019s disease: Dissociability, progression, and executive influences","volume":"69","author":"Bocanegra","year":"2015","journal-title":"Cortex"},{"key":"10.3233\/JAD-210163_ref34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.msard.2018.01.013","article-title":"Relationship between social cognition and traditional cognitive impairment in progressive multiple sclerosis and possible implicated neuroanatomical regions","volume":"20","author":"Ciampi","year":"2018","journal-title":"Mult Scler Relat Disord"},{"key":"10.3233\/JAD-210163_ref35","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/brain\/awp041","article-title":"A neuropsychological battery to detect specific executive and social cognitive impairments in early frontotemporal dementia","volume":"132","author":"Torralva","year":"2009","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref36","unstructured":"Stevens J (2002) Applied multivariate statistics for the social sciences, Lawrence Erlbaum Associates, Mahwah, N.J."},{"key":"10.3233\/JAD-210163_ref37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nn.4500","article-title":"Best practices in data analysis and sharing in neuroimaging using MRI","volume":"20","author":"Nichols","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.3233\/JAD-210163_ref38","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2013the methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210163_ref39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210163_ref40","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuroimage.2017.07.053","article-title":"Normalization of cortical thickness measurements across different T1 magnetic resonance imaging protocols by novel W-Score standardization","volume":"159","author":"Chung","year":"2017","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210163_ref41","doi-asserted-by":"crossref","first-page":"16265","DOI":"10.1523\/JNEUROSCI.2170-12.2012","article-title":"Region-specific hierarchy between atrophy, hypometabolism, and \u03b2-amyloid (A\u03b2) load in Alzheimer\u2019s disease dementia","volume":"32","author":"La Joie","year":"2012","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-210163_ref42","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/brain\/aww231","article-title":"Your perspective and my benefit: Multiple lesion models of self-other integration strategies during social bargaining","volume":"139","author":"Melloni","year":"2016","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrn.2016.167","article-title":"Scanning the horizon: Towards transparent and reproducible neuroimaging research","volume":"18","author":"Poldrack","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-210163_ref44","doi-asserted-by":"crossref","first-page":"116677","DOI":"10.1016\/j.neuroimage.2020.116677","article-title":"A multidimensional and multi-feature framework for cardiac interoception","volume":"212","author":"Fittipaldi","year":"2020","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210163_ref45","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1002\/hbm.24319","article-title":"Altered neural signatures of interoception in multiple sclerosis","volume":"39","author":"Salamone","year":"2018","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-210163_ref46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(10)70299-4","article-title":"Behavioural-variant frontotemporal dementia: Diagnosis, clinical staging, and management","volume":"10","author":"Piguet","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210163_ref47","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3389\/fneur.2019.00594","article-title":"Psychological and cognitive markers of behavioral variant frontotemporal dementia-a clinical neuropsychologist\u2019s view on diagnostic criteria and beyond","volume":"10","author":"Johnen","year":"2019","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-210163_ref48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11682-013-9261-0","article-title":"Neural correlates of the mini-SEA (Social cognition and Emotional Assessment) in behavioral variant frontotemporal dementia","volume":"8","author":"Bertoux","year":"2014","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JAD-210163_ref49","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1212\/WNL.0000000000009058","article-title":"Biological subtypes of Alzheimer disease: A systematic review and meta-analysis","volume":"94","author":"Ferreira","year":"2020","journal-title":"Neurology"},{"key":"10.3233\/JAD-210163_ref50","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrneurol.2014.178","article-title":"Brain connectivity in neurodegenerative diseases\u2013from phenotype to proteinopathy","volume":"10","author":"Pievani","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-210163_ref51","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/ejn.14666","article-title":"Hybrid modeling of alpha rhythm and the amplitude of low-frequency fluctuations abnormalities in the thalamocortical region and basal ganglia in Alzheimer\u2019s disease","volume":"52","author":"Cakir","year":"2020","journal-title":"Eur J Neurosci"},{"key":"10.3233\/JAD-210163_ref52","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/0891988716687872","article-title":"Nonmotor symptoms in Parkinson disease: A descriptive review on social cognition ability","volume":"30","author":"Palmeri","year":"2017","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.3233\/JAD-210163_ref53","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.1038\/npjparkd.2016.25","article-title":"Parkinson\u2019s disease as a system-level disorder","volume":"2","author":"Caligiore","year":"2016","journal-title":"NPJ Parkinsons Dis"},{"key":"10.3233\/JAD-210163_ref54","doi-asserted-by":"publisher","DOI":"10.31234\/osf.io\/tg2ay"},{"key":"10.3233\/JAD-210163_ref55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cortex.2015.11.007","article-title":"Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia","volume":"75","author":"Baez","year":"2016","journal-title":"Cortex"},{"key":"10.3233\/JAD-210163_ref56","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/brain\/aww231","article-title":"Your perspective and my benefit: Multiple lesion models of self-other integration strategies during social bargaining","volume":"139","author":"Melloni","year":"2016","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref57","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1001\/jamaneurol.2014.347","article-title":"Comparing moral judgments of patients with frontotemporal dementia and frontal stroke","volume":"71","author":"Baez","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-210163_ref58","doi-asserted-by":"crossref","first-page":"20160006","DOI":"10.1098\/rstb.2016.0006","article-title":"Feeling, learning from, and being aware of inner states: Interoceptive dimensions in neurodegeneration and stroke","volume":"371","author":"Garc\u00eda-Cordero","year":"2016","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.3233\/JAD-210163_ref59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnagi.2018.00011","article-title":"A modified reading the Mind in the Eyes test predicts behavioral variant frontotemporal dementia better than executive function tests","volume":"10","author":"Schroeter","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-210163_ref60","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neubiorev.2019.02.020","article-title":"More than words: Social cognition across variants of primary progressive aphasia","volume":"100","author":"Fittipaldi","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-210163_ref61","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jnnp-2017-316055","article-title":"Corticostriatal signatures of schadenfreude: Evidence from Huntington\u2019s disease","volume":"89","author":"Baez","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210163_ref62","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jnnp-2011-301849","article-title":"Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression","volume":"83","author":"Bertoux","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210163_ref63","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/PSY.0000000000000868","article-title":"At the heart of neurological dimensionality: Cross-nosological and multimodal cardiac interoceptive deficits","volume":"82","author":"Abrevaya","year":"2020","journal-title":"Psychosom Med"},{"key":"10.3233\/JAD-210163_ref64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cortex.2020.08.020","article-title":"From discourse to pathology: Automatic identification of Parkinson\u2019s disease patients via morphological measures across three languages","volume":"132","author":"Eyigoz","year":"2020","journal-title":"Cortex"},{"key":"10.3233\/JAD-210163_ref65","doi-asserted-by":"crossref","first-page":"116456","DOI":"10.1016\/j.neuroimage.2019.116456","article-title":"Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach","volume":"208","author":"Bachli","year":"2020","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210163_ref66","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1038\/s41598-017-04204-8","article-title":"Towards affordable biomarkers of frontotemporal dementia: A classification study via network\u2019s information sharing","volume":"7","author":"Dottori","year":"2017","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-210163_ref67","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1177\/1352458519888881","article-title":"Fatigue in multiple sclerosis is associated with multimodal interoceptive abnormalities","volume":"26","author":"Gonzalez Campo","year":"2020","journal-title":"Mult Scler"},{"key":"10.3233\/JAD-210163_ref68","doi-asserted-by":"crossref","first-page":"117998","DOI":"10.1016\/j.neuroimage.2021.117998","article-title":"Multimodal neurocognitive markers of frontal lobe epilepsy: Insights from ecological text processing","volume":"235","author":"Moguilner","year":"2021","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210163_ref69","doi-asserted-by":"crossref","first-page":"100176","DOI":"10.1016\/j.patter.2020.100176","article-title":"Uncovering social-contextual and individual mental health factors associated with violence via computational inference","volume":"2","author":"Santamar\u00eda-Garc\u00eda","year":"2021","journal-title":"Patterns (N Y)"},{"key":"10.3233\/JAD-210163_ref70","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/089826439300500401","article-title":"Predictors of in-home and out-of-home service use by family caregivers of Alzheimer\u2019s disease patients","volume":"5","author":"Biegel","year":"1993","journal-title":"J Aging Health"},{"key":"10.3233\/JAD-210163_ref71","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/jnnp.69.5.661","article-title":"Alzheimer\u2019s disease and frontotemporal dementia are differentiated by discriminant analysis applied to 99mTc HmPAO SPECT data","volume":"69","author":"Charpentier","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210163_ref72","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jnnp.60.2.158","article-title":"Comparison of positron emission tomography, cognition, and brain volume in Alzheimer\u2019s disease with and without severe abnormalities of white matter","volume":"60","author":"DeCarli","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210163_ref73","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/brain\/awf226","article-title":"Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer\u2019s disease","volume":"125","author":"Dixon","year":"2002","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref74","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3344\/kjp.2019.32.2.120","article-title":"Fibromyalgia diagnostic model derived from combination of American College of Rheumatology 1990 and 2011 criteria","volume":"32","author":"Ghavidel-Parsa","year":"2019","journal-title":"Korean J Pain"},{"key":"10.3233\/JAD-210163_ref75","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00004583-200004000-00019","article-title":"Instability of sleep patterns in children with attention-deficit\/hyperactivity disorder","volume":"39","author":"Gruber","year":"2000","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.3233\/JAD-210163_ref76","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1093\/brain\/awu029","article-title":"A bimodal neurophysiological study of motor control in attention-deficit hyperactivity disorder: A step towards core mechanisms?","volume":"137","author":"Heinrich","year":"2014","journal-title":"Brain"},{"key":"10.3233\/JAD-210163_ref77","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2114\/jpa2.26.569","article-title":"Contribution of physical fitness component to health status in middle-aged and elderly females","volume":"26","author":"Sato","year":"2007","journal-title":"J Physiol Anthropol"},{"key":"10.3233\/JAD-210163_ref78","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.wnn.0000208290.57370.a3","article-title":"Patterns of verbal memory performance in mild cognitive impairment, Alzheimer disease, and normal aging","volume":"19","author":"Greenaway","year":"2006","journal-title":"Cogn Behav Neurol"},{"key":"10.3233\/JAD-210163_ref79","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.acn.2006.06.012","article-title":"Using verbal fluency to detect very mild dementia of the Alzheimer type","volume":"21","author":"Gomez","year":"2006","journal-title":"Arch Clin Neuropsychol"},{"key":"10.3233\/JAD-210163_ref80","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/gps.930090807","article-title":"Neuropsychological tests as discriminators between dementia of Alzheimer type and frontotemporal dementia","volume":"9","author":"Elfgren","year":"1994","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-210163_ref81","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jalz.2007.04.374","article-title":"The Frontal Systems Behavior Scale discriminates frontotemporal dementia from Alzheimer\u2019s disease","volume":"3","author":"Malloy","year":"2007","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210163_ref82","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/psyg.12019","article-title":"Neuropsychological differentiation between Alzheimer\u2019s disease and dementia with Lewy bodies in a memory clinic","volume":"13","author":"Kawai","year":"2013","journal-title":"Psychogeriatrics"},{"key":"10.3233\/JAD-210163_ref83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0197-4580(00)00238-4","article-title":"Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly","volume":"22","author":"Wolf","year":"2001","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210163_ref84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-018-0282-8","article-title":"Autism, early psychosis, and social anxiety disorder: Understanding the role of social cognition and its relationship to disability in young adults with disorders characterized by social impairments","volume":"8","author":"Pepper","year":"2018","journal-title":"Transl Psychiatry"},{"key":"10.3233\/JAD-210163_ref85","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0022-3956(00)00025-X","article-title":"Cognitive function in euthymic bipolar patients, stabilized schizophrenic patients, and healthy controls","volume":"34","author":"Rossi","year":"2000","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-210163_ref86","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3233\/JAD-122296","article-title":"Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer\u2019s disease","volume":"37","author":"Lo","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210163_ref87","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3233\/JAD-200881","article-title":"Detection of cognitive dysfunction in elderly with a low educational level using a reaction-time attention task","volume":"78","author":"Schmidt","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210163_ref88","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3233\/JAD-150961","article-title":"Longitudinal changes in functional brain connectivity predicts conversion to Alzheimer\u2019s disease","volume":"51","author":"Serra","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210163_ref89","doi-asserted-by":"crossref","first-page":"586233","DOI":"10.3389\/fnagi.2020.586233","article-title":"Classifying Parkinson\u2019s disease patients with syntactic and socio-emotional verbal measures","volume":"12","author":"Baez","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-210163_ref90","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cortex.2017.07.003","article-title":"Parkinson\u2019s disease compromises the appraisal of action meanings evoked by naturalistic texts","volume":"100","author":"Garc\u00eda","year":"2018","journal-title":"Cortex"},{"key":"10.3233\/JAD-210163_ref91","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3233\/JAD-190861","article-title":"Can social cognition measurements differentiate behavioral variant frontotemporal dementia from Alzheimer\u2019s disease regardless of apathy?","volume":"74","author":"Mariano","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210163_ref92","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1017\/S1355617712001300","article-title":"Social Cognition and Emotional Assessment (SEA) is a marker of medial and orbital frontal functions: A voxel-based morphometry study in behavioral variant of frontotemporal degeneration","volume":"18","author":"Bertoux","year":"2012","journal-title":"J Int Neuropsychol Soc"},{"key":"10.3233\/JAD-210163_ref93","doi-asserted-by":"crossref","first-page":"16m11342","DOI":"10.4088\/JCP.16m11342","article-title":"Facial emotion recognition performance differentiates between behavioral variant frontotemporal dementia and major depressive disorder","volume":"79","author":"Chiu","year":"2018","journal-title":"J Clin Psychiatry"},{"key":"10.3233\/JAD-210163_ref94","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3233\/JAD-170650","article-title":"Combined socio-behavioral evaluation improves the differential diagnosis between the behavioral variant of frontotemporal dementia and Alzheimer\u2019s disease: In search of neuropsychological markers","volume":"61","author":"Dodich","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210163_ref95","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jagp.2017.12.008","article-title":"Social cognition differentiates behavioral variant frontotemporal dementia from other neurodegenerative diseases and psychiatric disorders","volume":"26","author":"Gossink","year":"2018","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-210163_ref96","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/WAD.0000000000000023","article-title":"How preserved is emotion recognition in Alzheimer disease compared with behavioral variant frontotemporal dementia?","volume":"29","author":"Bertoux","year":"2015","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-210163_ref97","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000355123","article-title":"Clinical utility of short social cognitive tests in early differentiation of behavioral variant frontotemporal dementia from Alzheimer\u2019s disease","volume":"3","author":"Buhl","year":"2013","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"10.3233\/JAD-210163_ref98","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1080\/13803395.2013.823911","article-title":"Assessment of socioemotional processes facilitates the distinction between frontotemporal lobar degeneration and Alzheimer\u2019s disease","volume":"35","author":"Narme","year":"2013","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.3233\/JAD-210163_ref99","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.acn.2007.01.024","article-title":"The Ekman 60 Faces Test as a diagnostic instrument in frontotemporal dementia","volume":"22","author":"Diehl-Schmid","year":"2007","journal-title":"Arch Clin Neuropsychol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-210163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:06:38Z","timestamp":1777370798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-210163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":99,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-210163","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}