{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:49:03Z","timestamp":1790434143740,"version":"4.1.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,6,29]]},"abstract":"<jats:p>Background: Behavioral variant frontotemporal dementia (bvFTD) is generally considered a young-onset dementia, although age at onset is highly variable. While several studies indicate clinical differences regarding age at onset, no biomarker validated cohort studies with updated clinical criteria have been performed. Objective: We aimed to examine behavior, cognition, and mortality over the full age spectrum in a cohort of bvFTD patients with neuroimaging, genetic, or histopathological confirmation and exclusion of positive Alzheimer\u2019s disease biomarkers or severe cerebrovascular damage. Methods: In total, 315 patients with a clinical diagnosis of probable or definite bvFTD were included from the Amsterdam Dementia Cohort and grouped into quartiles by age-at-diagnosis. Neuropsychiatric symptoms and cognitive functioning were assessed with the neuropsychiatric inventory, the geriatric depression scale and a neuropsychological test battery. Data on mortality was obtained from the Dutch municipal register. Associations between age-at-diagnosis and clinical features and mortality risk were examined. Results: Age-at-diagnosis ranged from 26 to 85 years and established quartiles with mean ages of 52\u00b16, 61\u00b12, 66\u00b12, and 74\u00b13 years. In the total sample, 44.4%exceeded an age of 65 years at time of diagnosis. Earlier age-at-diagnosis was associated with more severe behavioral symptoms, while later age-at-diagnosis was associated with more severe memory impairment. Unexpectedly, mortality risk was not associated with age-at-diagnosis. Conclusion: In bvFTD, symptom profile is associated with age-at-diagnosis. This should be taken into account with regard to diagnostics, patient management, and trial design. Additionally, based on our sample, the prevalence of late-onset bvFTD is higher than generally thought.<\/jats:p>","DOI":"10.3233\/jad-210179","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T13:22:04Z","timestamp":1621603324000},"page":"381-390","source":"Crossref","is-referenced-by-count":20,"title":["Clinical Phenotypes of Behavioral Variant Frontotemporal Dementia by Age at Onset"],"prefix":"10.1177","volume":"82","author":[{"given":"Jay L.P.","family":"Fieldhouse","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora T.","family":"Gossink","sequence":"additional","affiliation":[{"name":"GGZ inGeest, Department of Old Age Psychiatry, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"},{"name":"Reinier van Arkel, Geriatric and Hospital Psychiatric Centre (COZ), Jeroen Bosch Hospital, Den Bosch, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Feenstra","sequence":"additional","affiliation":[{"name":"GGZ Centraal, Department of Psychiatry, Amersfoort, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterre C.M.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afina W.","family":"Lemstra","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels D.","family":"Prins","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"},{"name":"Brain Research Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Bouwman","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Koene","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke F.M.","family":"Rhodius-Meester","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"},{"name":"Department of Internal medicine, Geriatric Medicine section, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freek","family":"Gillissen","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"},{"name":"Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Dols","sequence":"additional","affiliation":[{"name":"GGZ inGeest, Department of Old Age Psychiatry, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everard G.B.","family":"Vijverberg","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"},{"name":"Brain Research Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A.L.","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210179_ref1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"10.3233\/JAD-210179_ref2","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1017\/cjn.2016.25","article-title":"The prevalence and incidence of frontotemporal dementia: A systematic review","volume":"43","author":"Hogan","year":"2016","journal-title":"Can J Neurol Sci"},{"key":"10.3233\/JAD-210179_ref3","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.3233\/JAD-210179_ref4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S1474-4422(05)70223-4","article-title":"Frontotemporal dementia","volume":"4","author":"Neary","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210179_ref5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s12031-011-9538-y","article-title":"Estimating the number of persons with frontotemporal lobar degeneration in the US population","volume":"45","author":"Knopman","year":"2011","journal-title":"J Mol Neurosci"},{"key":"10.3233\/JAD-210179_ref6","doi-asserted-by":"crossref","first-page":"e1047","DOI":"10.1212\/WNL.0000000000005163","article-title":"Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration","volume":"90","author":"Seo","year":"2018","journal-title":"Neurology"},{"key":"10.3233\/JAD-210179_ref7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jalz.2014.03.002","article-title":"Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly","volume":"11","author":"Gislason","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210179_ref8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/jnnp.74.7.867","article-title":"The prevalence of frontal variant frontotemporal dementia and the frontal lobe syndrome in a population based sample of 85 year olds","volume":"74","author":"Gislason","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210179_ref9","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1212\/WNL.0b013e3181f5d4c4","article-title":"Incidence and subtypes of early-onset dementia in a geographically defined general population","volume":"75","author":"Garre-Olmo","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-210179_ref10","doi-asserted-by":"crossref","first-page":"e94901","DOI":"10.1371\/journal.pone.0094901","article-title":"Age-related incidence and family history in frontotemporal dementia: Data from the Swedish Dementia Registry","volume":"9","author":"Nilsson","year":"2014","journal-title":"PloS One"},{"key":"10.3233\/JAD-210179_ref11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13195-020-00753-9","article-title":"Characteristics and progression of patients with frontotemporal dementia in a regional memory clinic network","volume":"13","author":"Leroy","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-210179_ref12","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1001\/archneurol.2011.3323","article-title":"Frontotemporal dementia in elderly individuals","volume":"69","author":"Baborie","year":"2012","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-210179_ref13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1159\/000124751","article-title":"Cognitive function and psychiatric symptoms in early- and late-onset frontotemporal dementia","volume":"25","author":"Shinagawa","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-210179_ref14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1192\/bjp.bp.108.057034","article-title":"Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: Clinicopathological series and review of cases","volume":"194","author":"Velakoulis","year":"2009","journal-title":"Br J Psychiatry"},{"key":"10.3233\/JAD-210179_ref15","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/gps.1388","article-title":"The heterogeneity of frontotemporal dementia with regard to initial symptoms, qEEG and neuropathology","volume":"20","author":"Passant","year":"2005","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-210179_ref16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00401-010-0765-z","article-title":"Pathological correlates of frontotemporal lobar degeneration in the elderly","volume":"121","author":"Baborie","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-210179_ref17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/21678421.2017.1384020","article-title":"Mendelian forms of disease and age at onset affect survival in frontotemporal dementia","volume":"19","author":"Cosseddu","year":"2018","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.3233\/JAD-210179_ref18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/ene.13887","article-title":"Predictors of survival and progression in behavioural variant frontotemporal dementia","volume":"26","author":"Agarwal","year":"2019","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-210179_ref19","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1136\/jnnp-2018-318820","article-title":"Survival in memory clinic cohort is short, even in young-onset dementia","volume":"90","author":"Rhodius-Meester","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210179_ref20","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1468-1331.2008.02338.x","article-title":"Is early-onset clinically different from late-onset frontotemporal dementia?","volume":"15","author":"Borroni","year":"2008","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-210179_ref21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3233\/JAD-141044","article-title":"Clinical and neuropsychological comparisons of early-onset versus late-onset frontotemporal dementia: A CREDOS-FTD study","volume":"45","author":"Ye","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210179_ref22","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awv191","article-title":"The behavioural\/dysexecutive variant of Alzheimer\u2019s disease: Clinical, neuroimaging and pathological features","volume":"138","author":"Ossenkoppele","year":"2015","journal-title":"Brain"},{"key":"10.3233\/JAD-210179_ref23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2174\/1745017901309010088","article-title":"Epidemiology of early-onset dementia: A review of the literature","volume":"9","author":"Vieira","year":"2013","journal-title":"Clin Pract Epidemiol Ment Health"},{"key":"10.3233\/JAD-210179_ref24","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1474-4422(10)70159-9","article-title":"The diagnosis of young-onset dementia","volume":"9","author":"Rossor","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210179_ref25","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3233\/JAD-170850","article-title":"Amsterdam Dementia Cohort: Performing research to optimize care","volume":"62","author":"van der Flier","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210179_ref26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000270308","article-title":"Intelligence and age in a Dutch sample","volume":"8","author":"Verhage","year":"1965","journal-title":"Hum Dev"},{"key":"10.3233\/JAD-210179_ref27","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.3233\/JAD-210179_ref28","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1212\/WNL.48.5_Suppl_6.10S","article-title":"The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients","volume":"48","author":"Cummings","year":"1997","journal-title":"Neurology"},{"key":"10.3233\/JAD-210179_ref29","doi-asserted-by":"crossref","unstructured":"Sheikh JI , Yesavage JA (1986) Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. worth Press, US, pp. 165\u2013173.","DOI":"10.1300\/J018v05n01_09"},{"key":"10.3233\/JAD-210179_ref30","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): Current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.3233\/JAD-210179_ref31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-210179_ref32","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: A Frontal Assessment Battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"10.3233\/JAD-210179_ref33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/jnnp.73.2.126","article-title":"Visual association test to detect early dementia of the Alzheimer type","volume":"73","author":"Lindeboom","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210179_ref34","unstructured":"Rey A (1964) L\u2019examen clinique en psychologie, Presses universitaires de France."},{"key":"10.3233\/JAD-210179_ref35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1037\/h0044509","article-title":"The relation of the trail making test to organic brain damage","volume":"19","author":"Reitan","year":"1955","journal-title":"J Consult Psychol"},{"key":"10.3233\/JAD-210179_ref36","unstructured":"Wechsler D , Psychological C (1997) WAIS-III: Administration and scoring manual: Wechsler Adult Intelligence Scale. Psychological Corporation, San Antonio, TX."},{"key":"10.3233\/JAD-210179_ref37","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions","volume":"18","author":"Stroop","year":"1935","journal-title":"J Exp Psychol"},{"key":"10.3233\/JAD-210179_ref38","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"Hughes","year":"1982","journal-title":"Br J Psychiatry"},{"key":"10.3233\/JAD-210179_ref39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0028-3932(68)90038-9","article-title":"Differential behavioral effects in frontal lobe disease","volume":"6","author":"Benton","year":"1968","journal-title":"Neuropsychologia"},{"key":"10.3233\/JAD-210179_ref40","unstructured":"Warrington EK , James M , Thames Valley Test C (1991) The visual object and space perception battery, Thames Valley Test Company, Bury St. Edmunds."},{"key":"10.3233\/JAD-210179_ref41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1212\/CPJ.0000000000000429","article-title":"Apathy and functional disability in behavioral variant frontotemporal dementia","volume":"8","author":"Yassuda","year":"2018","journal-title":"Neurol Clin Pract"},{"key":"10.3233\/JAD-210179_ref42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/WAD.0b013e3182471c54","article-title":"Characterization of apathy in persons with frontotemporal dementia and the impact on family caregivers","volume":"27","author":"Merrilees","year":"2013","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-210179_ref43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jamda.2012.09.011","article-title":"Predictors of the time to institutionalization in young- versus late-onset dementia: Results from the Needs in Young Onset Dementia (NeedYD) study","volume":"14","author":"Bakker","year":"2013","journal-title":"J Am Med Dir Assoc"},{"key":"10.3233\/JAD-210179_ref44","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/jamaneurol.2016.2016","article-title":"Distinct subtypes of behavioral variant frontotemporal dementia based on patterns of network degeneration","volume":"73","author":"Ranasinghe","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-210179_ref45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0197-4580(91)90006-6","article-title":"The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer\u2019s disease","volume":"12","author":"Price","year":"1991","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210179_ref46","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.exger.2012.05.023","article-title":"Vascular dementia: Different forms of vessel disorders contribute to the development of dementia in the elderly brain","volume":"47","author":"Thal","year":"2012","journal-title":"Exp Gerontol"},{"key":"10.3233\/JAD-210179_ref47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(19)30394-1","article-title":"Age at symptom onset and death and disease duration in genetic frontotemporal dementia: An international retrospective cohort study","volume":"19","author":"Moore","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210179_ref48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jnnp-2011-301883","article-title":"Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion","volume":"83","author":"Khan","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210179_ref49","first-page":"371","article-title":"Late-onset behavioral variant of frontotemporal lobar degenerationversus Alzheimer\u2019s disease: Interest of cerebrospinal fluidbiomarkerratios","volume":"1","author":"Marelli","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210179_ref50","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/gps.4556","article-title":"Detecting clinical change with the CDR-FTLD: Differences between FTLD and AD dementia","volume":"32","author":"Mioshi","year":"2017","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-210179_ref51","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/0891988706286545","article-title":"The Cambridge Behavioral Inventory: Validation and application in a memory clinic","volume":"19","author":"Nagahama","year":"2006","journal-title":"J Geriatr Psychiatry Neurol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-210179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:06:04Z","timestamp":1777370764000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-210179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":51,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-210179","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]}}}