{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:01:24Z","timestamp":1791907284296,"version":"4.3.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:p>Background: The amyloid-\u03b2 oligomers, consisting of 10\u201320 monomers (A\u03b2O10\u201320), have strong neurotoxicity and are associated with cognitive impairment in Alzheimer\u2019s disease (AD). However, their role in patients with idiopathic normal pressure hydrocephalus (iNPH) is poorly understood. Objective: We hypothesized that cerebrospinal fluid (CSF) A\u03b2O10\u201320 accumulates in patients with iNPH, and its clearance after CSF shunting contributes to neurological improvement. We measured CSF A\u03b2O10\u201320 levels before and after CSF shunting in iNPH patients evaluating their diagnostic and prognostic role. Methods: We evaluated two iNPH cohorts: \u201cevaluation\u201d (cohort-1) with 32 patients and \u201cvalidation\u201d (cohort-2) with 13 patients. Comparison cohorts included: 27 neurologically healthy controls (HCs), and 16 AD, 15 Parkinson\u2019s disease (PD), and 14 progressive supranuclear palsy (PSP) patients. We assessed for all cohorts CSF A\u03b2O10\u201320 levels and their comprehensive clinical data. iNPH cohort-1 pre-shunting data were compared with those of comparison cohorts, using cohort-2 for validation. Next, we compared cohort-1\u2019s clinical and CSF data: 1) before and after CSF shunting, and 2) increased versus decreased A\u03b2O10\u201320 levels at baseline, 1 and 3 years after shunting. Results: Cohort-1 had higher CSF A\u03b2O10\u201320 levels than the HCs, PD, and PSP cohorts. This result was validated with data from cohort-2. CSF A\u03b2O10\u201320 levels differentiated cohort-1 from the PD and PSP groups, with an area under receiver operating characteristic curve of 0.94. A\u03b2O10\u201320 levels in cohort-1 decreased after CSF shunting. Patients with A\u03b2O10\u201320 decrease showed better cognitive outcome than those without. Conclusion: A\u03b2O10\u201320 accumulates in patients with iNPH and is eliminated by CSF shunting. A\u03b2O10\u201320 can be an applicable diagnostic and prognostic biomarker.<\/jats:p>","DOI":"10.3233\/jad-210226","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T10:21:18Z","timestamp":1626430878000},"page":"179-190","source":"Crossref","is-referenced-by-count":11,"title":["Cerebrospinal Fluid Amyloid-\u03b2 Oligomer Levels in Patients with Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1177","volume":"83","author":[{"given":"Kaito","family":"Kawamura","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Centre, Shinsuna Koto-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyasu","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mihara Memorial Hospital, Ota-cho, Isesaki-shi, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Motoi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuko","family":"Nojiri","sequence":"additional","affiliation":[{"name":"Medical Technology Innovation Center, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Centre, Shinsuna Koto-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Kamohara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"},{"name":"Department of Neurosurgery, Kugayama Hospital, Kita-Karasuyama, Setagaya-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostadin","family":"Karagiozov","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Brain Research Institute, Niigata University, Asahimachi, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Hongo Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210226_ref1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0022-510X(65)90016-X","article-title":"The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. 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