{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:59:09Z","timestamp":1787065149433,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>Background: Behavioral features may reflect proteinopathies predicting pathophysiology in neurodegenerative diseases. Objective: We aimed to investigate associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with neuropsychiatric features in dementia with Lewy bodies (DLB) compared with late-onset Alzheimer\u2019s disease (AD) and cognitively healthy people. Methods: Consecutive outpatients with DLB were paired with outpatients with AD according to sex, dementia stage, and cognitive scores, and with cognitively healthy controls according to sex and age to investigate associations of cerebrospinal fluid amyloid-\u03b2 (A\u03b2)42, A\u03b240, A\u03b238, total tau, phospho-tau Thr181, \u03b1-synuclein, ubiquitin, and neurofilament light with neuropsychiatric features according to APOE \u025b4 carrier status. Results: Overall, 27 patients with DLB (78.48\u00b19.0 years old, eleven APOE \u025b4 carriers) were paired with 27 patients with AD (81.00\u00b15.8 years old, twelve APOE \u025b4 carriers) and 27 controls (78.48\u00b18.7 years old, four APOE \u025b4 carriers); two thirds were women. Behavioral burden was more intense in DLB. Biomarker ratios reflecting amyloidogenesis and neurodegeneration in DLB were more similar to those in AD when patients carried APOE \u025b4 alleles. After corrections for false discovery rates, the following associations remained significant: in DLB, dysphoria was associated with tauopathy and indirect measures of amyloidogenesis, while in AD, agitation, and night-time behavior disturbances were associated with tauopathy, and delusions were associated with tauopathy and indirect measures of amyloidogenesis. Conclusion: Biomarker ratios were superior to A\u03b2 and tau biomarkers predicting neuropsychiatric symptoms when associations with isolated biomarkers were not significant. At the end, APOE \u025b4 carrier status influenced amyloidogenesis and tau pathology in DLB and in AD, and axonal degeneration only in DLB.<\/jats:p>","DOI":"10.3233\/jad-210272","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T15:55:55Z","timestamp":1619538955000},"page":"1295-1309","source":"Crossref","is-referenced-by-count":31,"title":["Associations of Neuropsychiatric Features with Cerebrospinal Fluid Biomarkers of Amyloidogenesis and Neurodegeneration in Dementia with Lewy Bodies Compared with Alzheimer\u2019s Disease and Cognitively Healthy People"],"prefix":"10.1177","volume":"81","author":[{"given":"Fabricio Ferreira","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery Escola Paulista de Medicina, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie C\u00e2mara","family":"Miraldo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Escola Paulista de Medicina, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Ferreira","family":"de Castro-Neto","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Escola Paulista de Medicina, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro Soares","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Escola Paulista de Medicina, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro Luiz de Andrade","family":"Matas","sequence":"additional","affiliation":[{"name":"Department of Neurology and 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