{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:56:19Z","timestamp":1789833379905,"version":"4.0.1"},"reference-count":156,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) is characterized by cognitive and neuropsychiatric symptoms (NPS) due to underlying neurodegenerative pathology. Some studies using electroencephalography (EEG) have shown increased epileptiform and epileptic activity in AD. Objective: This review and meta-analyses aims to synthesize the existing evidence for quantitative abnormalities of cortical excitability in AD and their relationship with clinical symptoms. Methods: We systematically searched and reviewed publications that quantitatively assessed cortical excitability, using transcranial magnetic stimulation (TMS) resting motor threshold (rMT), active motor threshold (aMT), motor evoked potential (MEP) or directly from the cortex using TMS-EEG via TMS-evoked potential (TEP). We meta-analyzed studies that assessed rMT and aMT using random effects model. Results: We identified 895 publications out of which 37 were included in the qualitative review and 30 studies using rMT or aMT were included in the meta-analyses. The AD group had reduced rMT (Hedges\u2019 g\u200a=\u200a\u20130.99, 95% CI [\u20131.29, \u20130.68], p\u200a&lt;\u200a0.00001) and aMT (Hedges\u2019 g\u200a=\u200a\u20130.87, 95% CI [\u20131.50, \u20130.24], p\u200a&lt;\u200a0.00001) as compared with control groups, indicative of higher cortical excitability. Qualitative review found some evidence of increased MEP amplitude, whereas findings related to TEP were inconsistent. There was some evidence supporting an inverse association between cortical excitability and global cognition. No publications reported on the relationship between cortical excitability and NPS. Conclusion: There is strong evidence of increased motor cortex excitability in AD and some evidence of an inverse association between excitability and cognition. Future studies should assess cortical excitability from non-motor areas using TMS-EEG and examine its relationship with cognition and NPS.<\/jats:p>","DOI":"10.3233\/jad-210311","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T04:46:07Z","timestamp":1625287567000},"page":"867-891","source":"Crossref","is-referenced-by-count":14,"title":["Quantitative Assessment of Cortical Excitability in Alzheimer\u2019s Dementia and Its Association with Clinical Symptoms: A Systematic Review and Meta-Analyses"],"prefix":"10.1177","volume":"88","author":[{"given":"Shaylyn","family":"Joseph","sequence":"first","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Canada"},{"name":"University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Patterson","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Canada"},{"name":"University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Blumberger","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Canada"},{"name":"University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek K.","family":"Rajji","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Canada"},{"name":"University of Toronto, Toronto, Canada"},{"name":"Toronto Dementia Research Alliance, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Canada"},{"name":"University of Toronto, 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Dement"},{"key":"10.3233\/JAD-210311_ref4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jalz.2010.04.005","article-title":"Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer\u2019s disease","volume":"7","author":"Marshall","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210311_ref5","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jalz.2011.05.2410","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease","volume":"7","author":"Lyketsos","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210311_ref6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jad.2015.09.069","article-title":"The prevalence of neuropsychiatric symptoms in Alzheimer\u2019s disease: Systematic review and meta-analysis","volume":"190","author":"Zhao","year":"2016","journal-title":"J Affect Disord"},{"key":"10.3233\/JAD-210311_ref7","doi-asserted-by":"crossref","first-page":"927804","DOI":"10.1155\/2014\/927804","article-title":"Behavioral and psychological symptoms in Alzheimer\u2019s disease","volume":"2014","author":"Li","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.3233\/JAD-210311_ref8","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1038\/s41598-018-26151-8","article-title":"The A\/T\/N biomarker scheme and patterns of brain atrophy assessed in mild cognitive impairment","volume":"8","author":"Ekman","year":"2018","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-210311_ref9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1212\/WNL.0000000000002923","article-title":"A\/T\/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers","volume":"87","author":"Jack","year":"2016","journal-title":"Neurology"},{"key":"10.3233\/JAD-210311_ref10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000363500","article-title":"Agitation in dementia: Relation to core cerebrospinal fluid biomarker levels","volume":"4","author":"Bloniecki","year":"2014","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"10.3233\/JAD-210311_ref11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/ana.72","article-title":"Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease","volume":"49","author":"Tekin","year":"2001","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-210311_ref12","doi-asserted-by":"crossref","first-page":"e1635","DOI":"10.1212\/WNL.0000000000008361","article-title":"Applying the ATN scheme in a memory clinic population: The ABIDE 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Neurosci"},{"key":"10.3233\/JAD-210311_ref42","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.celrep.2015.04.017","article-title":"Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease","volume":"11","author":"Yamamoto","year":"2015","journal-title":"Cell Rep"},{"key":"10.3233\/JAD-210311_ref43","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-210311_ref44","doi-asserted-by":"crossref","first-page":"e2259","DOI":"10.1212\/WNL.0000000000010612","article-title":"Association of epileptiform abnormalities and seizures in Alzheimer 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Neurol"},{"key":"10.3233\/JAD-210311_ref48","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.clinph.2012.01.010","article-title":"A practical guide to diagnostic transcranial magnetic stimulation: Report of an IFCN committee","volume":"123","author":"Groppa","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"10.3233\/JAD-210311_ref49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0013-4694(94)90029-9","article-title":"Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. 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