{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:47Z","timestamp":1787025887846,"version":"build-2736575974"},"reference-count":62,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,7,21]]},"abstract":"<jats:p>Background: D. Frank Benson and colleagues first described the clinical and neuropathological features of posterior cortical atrophy (PCA) from patients in the UCLA Neurobehavior Program. Objective: We reviewed the Program\u2019s subsequent clinical experience with PCA, and its potential for clarifying this relatively rare syndrome in comparison to the accumulated literature on PCA. Methods: Using the original criteria derived from this clinic, 65 patients with neuroimaging-supported PCA were diagnosed between 1995 and 2020. Results: On presentation, most had visual localization complaints and related visuospatial symptoms, but nearly half had memory complaints followed by symptoms of depression. Neurobehavioral testing showed predominant difficulty with visuospatial constructions, Gerstmann\u2019s syndrome, and Balint\u2019s syndrome, but also impaired memory and naming. On retrospective application of the current Consensus Criteria for PCA, 59 (91%) met PCA criteria with a modification allowing for \u201csignificantly greater visuospatial over memory and naming deficits.\u201d There were 37 deaths (56.9%) with the median overall survival of 10.3 years (95% CI: 9.6\u201313.6 years), consistent with a slow neurodegenerative disorder in most patients. Conclusion: Together, these findings recommend modifying the PCA criteria for \u201crelatively spared\u201d memory, language, and behavior to include secondary memory and naming difficulty and depression, with increased emphasis on the presence of Gerstmann\u2019s and Balint\u2019s syndromes.<\/jats:p>","DOI":"10.3233\/jad-210368","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:44:26Z","timestamp":1621946666000},"page":"493-502","source":"Crossref","is-referenced-by-count":21,"title":["Benson\u2019s Disease or Posterior Cortical Atrophy, Revisited"],"prefix":"10.1177","volume":"82","author":[{"given":"Oleg","family":"Yerstein","sequence":"first","affiliation":[{"name":"Department of Neurology, Lahey Hospital and Medical Center, Burlington, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Parand","sequence":"additional","affiliation":[{"name":"Department of Neurology, Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA"},{"name":"Neurology Service, Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jung","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Isaac","sequence":"additional","affiliation":[{"name":"Department of Linguistics, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA"},{"name":"Neurology Service, Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210368_ref1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/archneur.1988.00520310107024","article-title":"Posterior cortical atrophy","volume":"45","author":"Benson","year":"1988","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-210368_ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1001\/archneur.1994.00540150063018","article-title":"Posterior cortical atrophy. 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