{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:07:11Z","timestamp":1777396031261,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,11,23]]},"abstract":"<jats:p>Background: Magnetic resonance imaging (MRI) visual scales of brain atrophy are important for differential diagnosis of dementias in routine clinical practice. Atrophy patterns in early- and late-onset Alzheimer\u2019s disease (AD) can be different according to some studies. Objective: Our goal was to assess brain atrophy patterns in early- and late-onset AD using our recently developed simple MRI visual scales and evaluate their reliability. Methods: We used Hippocampo-horn percentage (Hip-hop) and Parietal Atrophy Score (PAS) to compare mediotemporal and parietal atrophy on brain MRI among 4 groups: 26 patients with early-onset AD, 21 younger cognitively normal persons, 32 patients with late-onset AD, and 36 older cognitively normal persons. Two raters scored all brain MRI to assess reliability of the Hip-hop and PAS. Brain MRIs were obtained from Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) database. Results: The patients with early-onset AD had significantly more pronounced mediotemporal and also parietal atrophy bilaterally compared to the controls (both p\u200a&lt;\u200a0.01). The patients with late-onset AD had significantly more pronounced only mediotemporal atrophy bilaterally compared to the controls (p\u200a&lt;\u200a0.000001), but parietal lobes were the same. Intra-rater and inter-rater reliability of both visual scales Hip-hop and PAS were almost perfect in all cases (weighted-kappa value ranged from 0.90 to 0.99). Conclusion: While mediotemporal atrophy detected using Hip-hop is universal across the whole AD age spectrum, parietal atrophy detected using PAS is worth rating only in early-onset AD. Hip-hop and PAS are very reliable MRI visual scales.<\/jats:p>","DOI":"10.3233\/jad-210372","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:51:34Z","timestamp":1633740694000},"page":"1259-1266","source":"Crossref","is-referenced-by-count":10,"title":["Hippocampo-Horn Percentage and Parietal Atrophy Score for Easy Visual Assessment of Brain Atrophy on Magnetic Resonance Imaging in Early- and Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"84","author":[{"given":"David","family":"Silhan","sequence":"first","affiliation":[{"name":"Department of Neurology, Charles University, Third Faculty of Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Pashkovska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charles University, Third Faculty of Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ales","family":"Bartos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charles University, Third Faculty of Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210372_ref1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuroscience.2020.11.015","article-title":"A multilevel view of the development of Alzheimer\u2019s 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