{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:03:25Z","timestamp":1777395805428,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:p>Background: Mounting evidence suggests that sex differences exist in cognitive reserve (CR) for cognitively unimpaired (CU) elderly individuals. Global left frontal connectivity (gLFC connectivity) is a reliable neural substrate of CR. Objective: The purpose of this study was to explore sex differences in gLFC connectivity among CU elderly individuals. Methods: One hundred thirteen normal controls (NCs) (women\u200a=\u200a66) and 132 individuals with subjective cognitive decline (SCD) (women\u200a=\u200a92) were recruited from the Sino Longitudinal Study on Cognitive Decline (SILCODE) (data 1). Among them, 88 subjects underwent amyloid-\u03b2 (A\u03b2) imaging, including 32 A\u03b2+ and 56 A\u03b2\u2013subjects. Forty-six subjects underwent another rs-fMRI examination (data 2) to validate the repeatability of the calculation of gLFC connectivity, which was determined through seed-based functional connectivity between the LFC and voxels throughout the whole brain. Independent-sample t-tests were used to evaluate the sex differences in gLFC connectivity across different subgroups (NC versus SCD, A\u03b2+ versus A\u03b2\u2013). Partial correlation analysis was used to calculate the correlations between gLFC connectivity and cognitive assessments. Results: Women exhibited lower gLFC connectivity in both the NC (p\u200a=\u200a0.001) and SCD (p\u200a=\u200a0.020) subgroups than men. Women also exhibited lower gLFC connectivity in both the A\u03b2\u2013(p\u200a=\u200a0.006) and A\u03b2+ (p\u200a=\u200a0.025) groups. However, the significant difference disappeared in the A\u03b2+ group when considering the covariates of age, education, total intracranial volume, and APOE4-carrying status. In addition, gLFC connectivity values were negatively correlated with Geriatric Depression Scale scores in the SCD group (r\u200a=\u200a\u20130.176, p\u200a=\u200a0.047). Conclusion: Women showed lower gLFC connectivity among CU elderly individuals.<\/jats:p>","DOI":"10.3233\/jad-210376","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:14:59Z","timestamp":1627391699000},"page":"653-663","source":"Crossref","is-referenced-by-count":7,"title":["Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE"],"prefix":"10.1177","volume":"83","author":[{"given":"Wenying","family":"Du","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changchang","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, 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