{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:57:02Z","timestamp":1788904622122,"version":"build-2803163510"},"reference-count":88,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,8,17]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) affects several cognitive functions and causes altered motor function. Fine motor deficits during object manipulation are evident in other neurological conditions, but have not been assessed in dementia patients yet. Objective: Investigate reactive and anticipatory grip force control in response to unexpected and expected load force perturbation in AD. Methods: Reactive and anticipatory grip force was investigated using a grip-device with force sensors. In this pilot study, fifteen AD patients and fourteen healthy controls performed a catching task. They held the device with one hand while a sandbag was dropped into an attached receptacle either by the experimenter or by the participant. Results: In contrast to studies of other neurological conditions, the majority of AD patients exerted lower static grip force levels than controls. Interestingly, patients who were slow in the Luria\u2019s three-step test produced normal grip forces. The timing and magnitude of reactive grip force control were largely preserved in patients. In contrast, timing and extent of anticipatory grip forces were impaired in patients, although anticipatory control was generally preserved. These deficits were correlated with decreasing Mini-Mental State Examination scores. Apraxia scores, assessed by pantomime of tool-use, did not correlate with performance in the catching task. Conclusion: We interpreted the decreased grip force in AD in the context of loss of strength and lethargy, typical for patients with AD. The lower static grip force during object manipulation may emerge as a potential biomarker for early stages of AD, but more studies with larger sample sizes are necessary.<\/jats:p>","DOI":"10.3233\/jad-210387","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T04:46:23Z","timestamp":1625287583000},"page":"1651-1665","source":"Crossref","is-referenced-by-count":5,"title":["Anticipatory and Reactive Grip Force Control in Patients with Alzheimer\u2019s Disease: A Pilot Study"],"prefix":"10.1177","volume":"82","author":[{"given":"Anna","family":"Gabriel","sequence":"first","affiliation":[{"name":"Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin T.","family":"Lehner","sequence":"additional","affiliation":[{"name":"Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"H\u00f6hler","sequence":"additional","affiliation":[{"name":"Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany"},{"name":"Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany"},{"name":"Department of Neurology, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa P.T.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Sport and Health Sciences, Technical University of Munich, Munich, 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Neurol"},{"key":"10.3233\/JAD-210387_ref2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/brain\/awaa395","article-title":"Untangling the association of amyloid-\u03b2 and tau with synaptic and axonal loss in Alzheimer\u2019s disease","volume":"144","author":"Pereira","year":"2021","journal-title":"Brain"},{"key":"10.3233\/JAD-210387_ref3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tins.2019.03.003","article-title":"A unifying hypothesis for Alzheimer\u2019s disease: From plaques to neurodegeneration","volume":"42","author":"Edwards","year":"2019","journal-title":"Trends Neurosci"},{"key":"10.3233\/JAD-210387_ref4","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/jgs.15341","article-title":"Motor and cognitive trajectories before dementia: Results from gait and brain study","volume":"66","author":"Montero-Odasso","year":"2018","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-210387_ref5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1586\/ern.11.57","article-title":"Loss of motor function in preclinical Alzheimer\u2019s disease","volume":"11","author":"Buchman","year":"2011","journal-title":"Expert Rev Neurother"},{"key":"10.3233\/JAD-210387_ref6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/JAD-200518","article-title":"Using a timed motor task to predict one-year functional decline in amnestic mild cognitive impairment","volume":"77","author":"Schaefer","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210387_ref7","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cortex.2013.07.016","article-title":"Apraxia - The cognitive side of motor control","volume":"57","author":"Goldenberg","year":"2014","journal-title":"Cortex"},{"key":"10.3233\/JAD-210387_ref8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/jnnp.2010.213371","article-title":"A new bedside test of gestures in stroke: The apraxia screen of TULIA (AST)","volume":"82","author":"Vanbellingen","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-210387_ref9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2147\/NDT.S47879","article-title":"Apraxia for differentiating Alzheimer\u2019s disease from subcortical vascular dementia and mild cognitive impairment","volume":"9","author":"Ozkan","year":"2013","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.3233\/JAD-210387_ref10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s11065-013-9235-4","article-title":"Apraxia and Alzheimer\u2019s disease: Review and perspectives","volume":"23","author":"Lesourd","year":"2013","journal-title":"Neuropsychol Rev"},{"key":"10.3233\/JAD-210387_ref11","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1136\/jnnp-2015-312945","article-title":"Utility of testing for apraxia and associated features in 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Where do they fit in the diagnosis of Alzheimer\u2019s disease?","volume":"2","author":"Marshall","year":"2012","journal-title":"Neurodegener Dis Manag"},{"key":"10.3233\/JAD-210387_ref25","doi-asserted-by":"crossref","first-page":"b75","DOI":"10.1136\/bmj.b75","article-title":"Dementia","volume":"338","author":"Burns","year":"2009","journal-title":"BMJ"},{"key":"10.3233\/JAD-210387_ref26","first-page":"27","article-title":"Dementia: A review","volume":"1","author":"Fymat","year":"2019","journal-title":"J Clin Psychiatry Neurosci"},{"key":"10.3233\/JAD-210387_ref27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/practneurol-2015-001354","article-title":"The clinical assessment of apraxia","volume":"16","author":"Cassidy","year":"2016","journal-title":"Pract Neurol"},{"key":"10.3233\/JAD-210387_ref28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1017\/S1355617716000618","article-title":"Rethinking the cognitive mechanisms underlying pantomime of tool use: 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tools","volume":"42","author":"Lowe","year":"1999","journal-title":"Ergonomics"},{"key":"10.3233\/JAD-210387_ref43","doi-asserted-by":"crossref","first-page":"igaa050","DOI":"10.1093\/geroni\/igaa050","article-title":"Association between physical performance and cognitive function in older adults across multiple studies: A pooled analysis study","volume":"4","author":"Handing","year":"2020","journal-title":"Innov Aging"},{"key":"10.3233\/JAD-210387_ref44","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1017\/S1041610217002861","article-title":"A longitudinal study of cognitive decline in rural Tanzania: Rates and potentially modifiable risk factors","volume":"30","author":"Heward","year":"2018","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-210387_ref45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12877-018-0918-9","article-title":"Association among handgrip strength, body mass index and decline in cognitive function among the elderly 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adults","volume":"99","author":"Doi","year":"2019","journal-title":"Phys Ther"},{"key":"10.3233\/JAD-210387_ref49","doi-asserted-by":"crossref","first-page":"625551","DOI":"10.3389\/fnagi.2021.625551","article-title":"Grip strength and the risk of cognitive decline and dementia: A systematic review and meta-analysis of longitudinal cohort studies","volume":"13","author":"Cui","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-210387_ref50","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.clineuro.2011.01.011","article-title":"Arbitrary visuo-motor mapping during object manipulation in mild cognitive impairment and Alzheimer\u2019s disease: A pilot study","volume":"113","author":"Ameli","year":"2011","journal-title":"Clin Neurol Neurosurg"},{"key":"10.3233\/JAD-210387_ref51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G* Power 3: A flexible statistical power analysis program for the social, 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