{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:48Z","timestamp":1787025888406,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,11,9]]},"abstract":"<jats:p>Background: Primary progressive aphasia (PPA) is associated with amyloid-\u03b2 (A\u03b2) pathology. However, clinical feature of PPA based on A\u03b2 positivity remains unclear. Objective: We aimed to assess the prevalence of A\u03b2 positivity in patients with PPA and compare the clinical characteristics of patients with A\u03b2-positive (A+) and A\u03b2-negative (A\u2013) PPA. Further, we applied A\u03b2 and tau classification system (AT system) in patients with PPA for whom additional information of in vivo tau biomarker was available. Methods: We recruited 110 patients with PPA (41 semantic [svPPA], 27 non-fluent [nfvPPA], 32 logopenic [lvPPA], and 10 unclassified [ucPPA]) who underwent A\u03b2-PET imaging at multi centers. The extent of language impairment and cortical atrophy were compared between the A+ and A\u2013PPA subgroups using general linear models. Results: The prevalence of A\u03b2 positivity was highest in patients with lvPPA (81.3%), followed by ucPPA (60.0%), nfvPPA (18.5%), and svPPA (9.8%). The A+ PPA subgroup manifested cortical atrophy mainly in the left superior temporal\/inferior parietal regions and had lower repetition scores compared to the A\u2013PPA subgroup. Further, we observed that more than 90% (13\/14) of the patients with A+ PPA had tau deposition. Conclusion: Our findings will help clinicians understand the patterns of language impairment and cortical atrophy in patients with PPA based on A\u03b2 deposition. Considering that most of the A+ PPA patents are tau positive, understanding the influence of Alzheimer\u2019s disease biomarkers on PPA might provide an opportunity for these patients to participate in clinical trials aimed for treating atypical Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3233\/jad-210392","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T11:44:54Z","timestamp":1632483894000},"page":"633-645","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristic in Primary Progressive Aphasia in Relation to Alzheimer\u2019s Disease Biomarkers"],"prefix":"10.1177","volume":"84","author":[{"given":"Sung Hoon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"},{"name":"Neuroscience Center, Samsung Medical Center, Seoul, Korea"},{"name":"Department of Neurology, Korea University Guro Hospital, Korea University 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Medicine, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hyoung","family":"Lyoo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyemin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"},{"name":"Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"},{"name":"Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Beom","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"},{"name":"Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee Kyung","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"},{"name":"Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"},{"name":"Neuroscience Center, Samsung Medical Center, Seoul, Korea"},{"name":"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea"},{"name":"Samsung Alzheimer Research Center and Center for Clinical Epidemiology Medical Center, Seoul, Korea"},{"name":"Department of Intelligent Precision Healthcare Convergence, SAIHST, Sungkyunkwan University, Seoul, 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