{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:05:31Z","timestamp":1777395931025,"version":"3.51.4"},"reference-count":66,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:p>Background: Growing evidence supports that receptor for advanced glycation end products (RAGE) and glyoxalase-1 (GLO-1) are implicated in the pathophysiology of Alzheimer\u2019s disease (AD). Extracellular vesicles (EVs) are nanovesicles secreted by almost all cell types, contribute to cellular communication, and are implicated in AD pathology. Recently, EVs are considered as promising tools to identify reliable biomarkers in AD. Objective: The aim of our study was to determine the levels of RAGE and GLO-1 in circulating EVs from mild cognitive impairment (MCI) and AD patients and to analyze their correlation with the clinical Mini-Mental State Examination and Montreal Cognitive Assessment scores. We have studied the possibility that neuronal cells could release and transfer GLO-1 through EVs. Methods: RAGE and GLO-1 levels were measured in circulating EVs, respectively, by Luminex assay and western blot. Released-EVs from SK-N-SH neuronal cells were isolated and GLO-1 levels were determined by western blot. Results: Our data showed higher levels of RAGE in EVs from late AD patients while GLO-1 levels in EVs from early AD were lower as compared to control and MCI patients. Interestingly, levels of RAGE and GLO-1 in EVs were correlated with the cognitive scores regardless of age. For the first time, we demonstrated that GLO-1 was released from neuronal cells through EVs. Conclusion: Although more samples will be needed, our preliminary results support the use of peripheral EVs cargo as new tools for the discovery of peripheral AD biomarkers.<\/jats:p>","DOI":"10.3233\/jad-210441","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T11:51:45Z","timestamp":1630669905000},"page":"227-237","source":"Crossref","is-referenced-by-count":7,"title":["Levels of Receptor for Advanced Glycation End Products and Glyoxalase-1 in the Total Circulating Extracellular Vesicles from Mild Cognitive Impairment and Different Stages of Alzheimer\u2019s Disease Patients"],"prefix":"10.1177","volume":"84","author":[{"given":"Mohamed","family":"Haddad","sequence":"first","affiliation":[{"name":"Institut National de Recherche Scientifique\u2013Centre Armand-Frappier Sant\u00e9 Biotechnologie, Laval, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgane","family":"Perrotte","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Scientifique\u2013Centre Armand-Frappier Sant\u00e9 Biotechnologie, Laval, Qu\u00e9bec, Canada"},{"name":"R\u00e9seau Qu\u00e9b\u00e9coisde Recherche sur le Vieillissement, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ra\u00e2fet","family":"Ben Khedher","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Scientifique\u2013Centre Armand-Frappier Sant\u00e9 Biotechnologie, Laval, Qu\u00e9bec, Canada"},{"name":"R\u00e9seau Qu\u00e9b\u00e9coisde Recherche sur le Vieillissement, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Madec","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Scientifique\u2013Centre Armand-Frappier Sant\u00e9 Biotechnologie, Laval, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelie","family":"Lepage","sequence":"additional","affiliation":[{"name":"Department of Medicine, Geriatric Division, Research Center on Aging, Sherbrooke University, Sherbrooke, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Department of Medicine, Geriatric Division, Research Center on Aging, Sherbrooke University, Sherbrooke, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Ramassamy","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Scientifique\u2013Centre Armand-Frappier Sant\u00e9 Biotechnologie, Laval, Qu\u00e9bec, Canada"},{"name":"R\u00e9seau Qu\u00e9b\u00e9coisde Recherche sur le Vieillissement, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210441_ref1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: A systematic review and metaanalysis","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210441_ref2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","article-title":"A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer\u2019s disease","volume":"26","author":"Barthelemy","year":"2020","journal-title":"Nat Med"},{"key":"10.3233\/JAD-210441_ref3","doi-asserted-by":"crossref","first-page":"dmm031781","DOI":"10.1242\/dmm.031781","article-title":"Molecular biomarkers of Alzheimer\u2019s disease: Progress and prospects","volume":"11","author":"Lashley","year":"2018","journal-title":"Dis Model Mech"},{"key":"10.3233\/JAD-210441_ref4","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer\u2019s disease: The IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210441_ref5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00401-018-1932-x","article-title":"Current state of Alzheimer\u2019s fluid biomarkers","volume":"136","author":"Molinuevo","year":"2018","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-210441_ref6","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.str.2010.05.017","article-title":"Structural basis for ligand recognition and activation of RAGE","volume":"18","author":"Koch","year":"2010","journal-title":"Structure"},{"key":"10.3233\/JAD-210441_ref7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/382685a0","article-title":"RAGE and amyloid-beta peptide neurotoxicity in Alzheimer\u2019s disease","volume":"382","author":"Yan","year":"1996","journal-title":"Nature"},{"key":"10.3233\/JAD-210441_ref8","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1038\/sj.emboj.7600415","article-title":"RAGE potentiates Abeta-induced perturbation ofneuronal function in transgenic mice","volume":"23","author":"Arancio","year":"2004","journal-title":"EMBO J"},{"key":"10.3233\/JAD-210441_ref9","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/jnr.21252","article-title":"Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides","volume":"85","author":"Bourne","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.3233\/JAD-210441_ref10","doi-asserted-by":"crossref","first-page":"e673","DOI":"10.1038\/cddis.2013.180","article-title":"Glycation exacerbates the neuronal toxicity ofbeta-amyloid","volume":"4","author":"Li","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.3233\/JAD-210441_ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.10.056","article-title":"A\u03b2-AGE aggravates cognitive deficit in rats via RAGE pathway","volume":"257","author":"Chen","year":"2014","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-210441_ref12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nm890","article-title":"RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain","volume":"9","author":"Deane","year":"2003","journal-title":"Nat Med"},{"key":"10.3233\/JAD-210441_ref13","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1161\/01.STR.0000143452.85382.d1","article-title":"RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier","volume":"35","author":"Deane","year":"2004","journal-title":"Stroke"},{"key":"10.3233\/JAD-210441_ref14","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.bcp.2010.01.013","article-title":"Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging","volume":"79","author":"Yan","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.3233\/JAD-210441_ref15","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1001\/archneur.62.11.1734","article-title":"Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia","volume":"62","author":"Emanuele","year":"2005","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-210441_ref16","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/00207454.2016.1193861","article-title":"Plasma levels of soluble receptor for advanced glycation end products in Alzheimer\u2019s disease","volume":"127","author":"Xu","year":"2017","journal-title":"Int J Neurosci"},{"key":"10.3233\/JAD-210441_ref17","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00702-008-0069-9","article-title":"Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment","volume":"115","author":"Ghidoni","year":"2008","journal-title":"J Neural Transm"},{"key":"10.3233\/JAD-210441_ref18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0006-8993(00)03075-4","article-title":"Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer\u2019s disease","volume":"888","author":"Sasaki","year":"2001","journal-title":"Brain Res"},{"key":"10.3233\/JAD-210441_ref19","doi-asserted-by":"crossref","first-page":"e1117","DOI":"10.1038\/cddis.2014.89","article-title":"D-ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation","volume":"5","author":"Han","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.3233\/JAD-210441_ref20","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/CS20140683","article-title":"The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases","volume":"128","author":"Maessen","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.3233\/JAD-210441_ref21","doi-asserted-by":"crossref","first-page":"238485","DOI":"10.1155\/2014\/238485","article-title":"Role of methylglyoxal in Alzheimer\u2019s disease","volume":"2014","author":"Angeloni","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.3233\/JAD-210441_ref22","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.3390\/ijms20194906","article-title":"Methylglyoxal and glyoxal as potential peripheral markers for mci diagnosis and their effects on the expression of neurotrophic, inflammatory and neurodegenerative factors in neurons and in neuronal derived-extracellular vesicles","volume":"20","author":"Haddad","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-210441_ref23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neurobiolaging.2005.11.007","article-title":"Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer\u2019s disease brains","volume":"28","author":"Kuhla","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210441_ref24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: Exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-210441_ref25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, andintercellular interactions of exosomes and other extracellularvesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.3233\/JAD-210441_ref26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1247\/csf.16014","article-title":"Significance of extracellular vesicles: Pathobiological roles in disease","volume":"41","author":"Yamamoto","year":"2016","journal-title":"Cell Struct Funct"},{"key":"10.3233\/JAD-210441_ref27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jnr.24113","article-title":"A novel cell-cell communication mechanism in the nervous system: Exosomes","volume":"96","author":"Zhang","year":"2018","journal-title":"J Neurosci Res"},{"key":"10.3233\/JAD-210441_ref28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/bmc-2015-0033","article-title":"Physiological and pathological roles of exosomes in the nervous system","volume":"7","author":"Yuyama","year":"2016","journal-title":"Biomol Concepts"},{"key":"10.3233\/JAD-210441_ref29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcdb.2015.02.007","article-title":"Extracellular vesicles\u2013Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases","volume":"40","author":"Coleman","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.3233\/JAD-210441_ref30","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbrc.2016.09.090","article-title":"The role of extracellular vesicles in neurodegenerative diseases","volume":"483","author":"Quek","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-210441_ref31","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer\u2019s disease beta-amyloid peptides are released in association with exosomes","volume":"103","author":"Rajendran","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-210441_ref32","first-page":"6206","article-title":"The transport mechanism of extracellular vesicles at the blood-brain barrier","volume":"23","author":"Junichi","year":"2017","journal-title":"Curr Pharm Des"},{"key":"10.3233\/JAD-210441_ref33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12195-016-0458-3","article-title":"Elucidation of Exosome migration across the blood-brain barrier model","volume":"9","author":"Chen","year":"2016","journal-title":"Cell Mol Bioeng"},{"key":"10.3233\/JAD-210441_ref34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat Biotechnol"},{"key":"10.3233\/JAD-210441_ref35","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jalz.2014.06.008","article-title":"Identification of preclinical Alzheimer\u2019s disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study","volume":"11","author":"Fiandaca","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210441_ref36","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1096\/fj.201600816R","article-title":"Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer\u2019s disease","volume":"30","author":"Goetzl","year":"2016","journal-title":"FASEB J"},{"key":"10.3233\/JAD-210441_ref37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/acn3.309","article-title":"Plasma neuronal exosomal levels of Alzheimer\u2019s disease biomarkers in normal aging","volume":"3","author":"Abner","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"key":"10.3233\/JAD-210441_ref38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dadm.2016.04.001","article-title":"Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile","volume":"3","author":"Winston","year":"2016","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.3233\/JAD-210441_ref39","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1083\/jcb.143.7.2067","article-title":"The cell adhesion molecule L1 is developmentally regulated in the renal epithelium and is involved in kidney branching morphogenesis","volume":"143","author":"Debiec","year":"1998","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-210441_ref40","first-page":"2792","article-title":"L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer","volume":"15","author":"Chen","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.3233\/JAD-210441_ref41","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JAD-181272","article-title":"Circulating and extracellular vesicles levels of N-(1-Carboxymethyl)-L-Lysine (CML) differentiate early to moderate Alzheimer\u2019s disease","volume":"69","author":"Haddad","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210441_ref42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neurobiolaging.2019.10.010","article-title":"Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer\u2019s disease","volume":"86","author":"Perrotte","year":"2020","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210441_ref43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. Apractical method for grading the cognitive state of patients for theclinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-210441_ref44","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-210441_ref45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0047-6374(00)00240-2","article-title":"The SENIEUR protocol after 16 years","volume":"122","author":"Pawelec","year":"2001","journal-title":"Mech Ageing Dev"},{"key":"10.3233\/JAD-210441_ref46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: Clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-210441_ref47","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: Report of theNINCDS-ADRDA Work Group under the auspices of Department of Healthand Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.3233\/JAD-210441_ref48","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.trci.2019.06.008","article-title":"Alzheimer\u2019s disease mechanisms in peripheral cells: Promises and challenges","volume":"5","author":"Trushina","year":"2019","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.3233\/JAD-210441_ref49","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10571-015-0233-3","article-title":"Role of RAGE in Alzheimer\u2019s disease","volume":"36","author":"Cai","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-210441_ref50","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1073\/pnas.91.11.4766","article-title":"Advanced glycation end products contribute to amyloidosis in Alzheimer disease","volume":"91","author":"Vitek","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"10.3233\/JAD-210441_ref51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3233\/JAD-2011-110776","article-title":"Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-beta1-42 uptake into mouse brain","volume":"28","author":"Sugihara","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210441_ref52","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.2337\/dc11-0958","article-title":"Serum level of endogenous secretory receptor for advanced glycation end products and other factors in type 2 diabetic patients with mild cognitive impairment","volume":"34","author":"Chen","year":"2011","journal-title":"Diabetes Care"},{"key":"10.3233\/JAD-210441_ref53","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.bbrc.2018.04.181","article-title":"Detection of the receptor for advanced glycation endproducts in neuronally-derived exosomes in plasma","volume":"500","author":"Patterson","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-210441_ref54","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.redox.2013.12.016","article-title":"Role of advanced glycation end products in cellular signaling","volume":"2","author":"Ott","year":"2014","journal-title":"Redox Biol"},{"key":"10.3233\/JAD-210441_ref55","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/dmrr.233","article-title":"The AGE-receptor in the pathogenesis of diabetic complications","volume":"17","author":"Vlassara","year":"2001","journal-title":"Diabetes Metab Res Rev"},{"key":"10.3233\/JAD-210441_ref56","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbadis.2015.09.020","article-title":"Exosomes as new diagnostic tools in CNS diseases","volume":"1862","author":"Kanninen","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-210441_ref57","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1073\/pnas.0402338101","article-title":"Role for glyoxalase I in Alzheimer\u2019s disease","volume":"101","author":"Chen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-210441_ref58","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/cn3001679","article-title":"Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer\u2019s disease","volume":"4","author":"More","year":"2013","journal-title":"ACS Chem Neurosci"},{"key":"10.3233\/JAD-210441_ref59","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/cercor\/bhh123","article-title":"Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer\u2019s disease brains","volume":"15","author":"L\u00fcth","year":"2005","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-210441_ref60","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s40478-019-0795-2","article-title":"Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer\u2019s disease","volume":"7","author":"Whelan","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.3233\/JAD-210441_ref61","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.freeradbiomed.2018.10.452","article-title":"Blood-based redox-signature and theirassociation to the cognitive scores in MCI and Alzheimer\u2019s diseasepatients","volume":"130","author":"Perrotte","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.3233\/JAD-210441_ref62","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.2337\/db16-0153","article-title":"Improved glycemic control andvascular function in overweight and obese subjects by glyoxalase 1inducer formulation","volume":"65","author":"Xue","year":"2016","journal-title":"Diabetes"},{"key":"10.3233\/JAD-210441_ref63","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/ijms18010188","article-title":"Methylglyoxal-glyoxalase 1 balance: The root of vascular damage","volume":"18","author":"Nigro","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-210441_ref64","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fcvm.2018.00117","article-title":"Dicarbonyl stress and glyoxalase-1 in skeletal muscle: Implications for insulin resistance and type 2 diabetes","volume":"5","author":"Mey","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"10.3233\/JAD-210441_ref65","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jalz.2019.09.004","article-title":"Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer\u2019s disease","volume":"16","author":"Elahi","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210441_ref66","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12877-015-0103-3","article-title":"Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults","volume":"15","author":"Trzepacz","year":"2015","journal-title":"BMC Geriatr"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-210441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:09Z","timestamp":1777370829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-210441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":66,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-210441","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,26]]}}}