{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:03:23Z","timestamp":1777395803598,"version":"3.51.4"},"reference-count":80,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:p>Background: Approximately 90%of persons living with dementia experience behavioral symptoms, including frontal lobe features involving motivation, planning, social behavior, language, personality, mood, swallowing, and gait. Objective: We conducted a two-stage study with a development sample (n\u200a=\u200a586) and validation sample (n\u200a=\u200a274) to evaluate a brief informant-rated measure of non-cognitive features of frontal lobe dysfunction: the Frontal Behavioral Battery (FBB). Methods: In the development sample, internal consistency, principal factor analysis, and correlations between the FBB and outcomes were evaluated. In the validation sample, we examined (a) FBB scores by diagnosis, (b) known-group validity by demographics, subjective complaints, and dementia staging, and (c) correlation between FBB and MRI volumes. Receiver operator characteristic curves assessed the ability of the FBB to discriminate individuals with frontal lobe features due to a neurodegenerative disease. Results: The FBB characterized 11 distinct frontal lobe features. Individuals with dementia with Lewy bodies and frontotemporal degeneration had the greatest number of frontal lobe features. Premorbid personality traits of extroversion, agreeableness, and openness were associated with fewer frontal lobe behavioral symptoms, while subjective cognitive complaints were associated with greater symptoms. The FBB provided very good discrimination between individuals with and without cognitive impairment (diagnostic odds ratio: 13.1) and between individuals with and without prominent frontal lobe symptoms (diagnostic odds ratio: 84.8). Conclusion: The FBB may serve as an effective and efficient method to assess the presence of non-cognitive symptoms associated with frontal lobe dysfunction, but in a brief fashion that could facilitate its use in clinical care and research.<\/jats:p>","DOI":"10.3233\/jad-210446","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T12:52:11Z","timestamp":1627995131000},"page":"721-739","source":"Crossref","is-referenced-by-count":3,"title":["The Frontal Behavioral Battery: A Measure of Frontal Lobe Symptoms in Brain Aging and Neurodegenerative Disease"],"prefix":"10.1177","volume":"83","author":[{"given":"James E.","family":"Galvin","sequence":"first","affiliation":[{"name":"Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Cohen","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keri K.","family":"Greenfield","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"Walker","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210446_ref3","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jalz.2018.02.004","article-title":"Detecting agitation and aggression in people with dementia using sensors-A systematic review","volume":"14","author":"Khan","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210446_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/opn.12158","article-title":"Formal caregivers\u2019 experiences of aggressive behaviour in older people living with dementia in nursing homes: A systematic review","volume":"12","author":"Holst","year":"2017","journal-title":"Int J Older People Nurs"},{"key":"10.3233\/JAD-210446_ref5","first-page":"52","article-title":"Negative symptoms in patients with Alzheimer\u2019s disease","volume":"3","author":"Galynker","year":"1995","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-210446_ref6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1017\/S1041610205001572","article-title":"A randomized trial of early psychiatric intervention in residential care: Impact on health outcomes","volume":"17","author":"Kotynia-English","year":"2005","journal-title":"Int Psychogeratr"},{"key":"10.3233\/JAD-210446_ref7","doi-asserted-by":"crossref","first-page":"e0241641","DOI":"10.1371\/journal.pone.0241641","article-title":"The Quick Physical Activity Rating (QPAR) scale: A brief assessment of physical activity in older adults with and without cognitive impairment","volume":"15","author":"Galvin","year":"2020","journal-title":"PLoS One"},{"key":"10.3233\/JAD-210446_ref8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-201326","article-title":"Comon of the caregiving experience of grief, burden, and quality of life in dementia with Lewy bodies, Alzheimer\u2019s disease, and Parkinson\u2019s disease dementia","volume":"80","author":"Rigby","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210446_ref9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cger.2019.11.010","article-title":"Managing behavioral and psychological symptoms of dementia","volume":"36","author":"Gerlach","year":"2020","journal-title":"Clin Geriatr Med"},{"key":"10.3233\/JAD-210446_ref10","unstructured":"Pirau L , Lui F (2020) Frontal lobe syndrome. 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