{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:03:08Z","timestamp":1777395788184,"version":"3.51.4"},"reference-count":94,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:p>Background: Apolipoprotein E (APOE) genotypes typically increase risk of amyloid-\u03b2 deposition and onset of clinical Alzheimer\u2019s disease (AD). However, cognitive assessments in APOE transgenic AD mice have resulted in discord. Objective: Analysis of 31 peer-reviewed AD APOE mouse publications (n\u200a=\u200a3,045 mice) uncovered aggregate trends between age, APOE genotype, gender, modulatory treatments, and cognition. Methods: T-tests with Bonferroni correction (significance\u200a=\u200ap\u200a&lt;\u200a0.002) compared age-normalized Morris water maze (MWM) escape latencies in wild type (WT), APOE2 knock-in (KI2), APOE3 knock-in (KI3), APOE4 knock-in (KI4), and APOE knock-out (KO) mice. Positive treatments (t+) to favorably modulate APOE to improve cognition, negative treatments (t\u2013) to perturb etiology and diminish cognition, and untreated (t0) mice were compared. Machine learning with random forest modeling predicted MWM escape latency performance based on 12 features: mouse genotype (WT, KI2, KI3, KI4, KO), modulatory treatment (t+, t\u2013, t0), mouse age, and mouse gender (male\u200a=\u200ag_m; female\u200a=\u200ag_f, mixed gender\u200a=\u200ag_mi). Results: KI3 mice performed significantly better in MWM, but KI4 and KO performed significantly worse than WT. KI2 performed similarly to WT. KI4 performed significantly worse compared to every other genotype. Positive treatments significantly improved cognition in WT, KI4, and KO compared to untreated. Interestingly, negative treatments in KI4 also significantly improved mean MWM escape latency. Random forest modeling resulted in the following feature importance for predicting superior MWM performance: [KI3, age, g_m, KI4, t0, t+, KO, WT, g_mi, t\u2013, g_f, KI2]\u200a=\u200a[0.270, 0.094, 0.092, 0.088, 0.077, 0.074, 0.069, 0.061, 0.058, 0.054, 0.038, 0.023]. Conclusion: APOE3, age, and male gender was most important for predicting superior mouse cognitive performance.<\/jats:p>","DOI":"10.3233\/jad-210492","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:16:37Z","timestamp":1627391797000},"page":"435-450","source":"Crossref","is-referenced-by-count":5,"title":["Aggregate Trends of Apolipoprotein E on Cognition in Transgenic Alzheimer\u2019s Disease Mice"],"prefix":"10.1177","volume":"83","author":[{"given":"Yassin","family":"Watson","sequence":"first","affiliation":[{"name":"Laboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenae","family":"Nelson","sequence":"additional","affiliation":[{"name":"Laboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University 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Med"},{"key":"10.3233\/JAD-210492_ref5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3233\/JAD-2006-9S340","article-title":"On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease","volume":"9","author":"Roses","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210492_ref6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13024-020-00413-4","article-title":"APOE2: Protective mechanism and therapeutic implications for Alzheimer\u2019s disease","volume":"15","author":"Li","year":"2020","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-210492_ref7","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1523\/JNEUROSCI.2994-18.2019","article-title":"Differential signaling mediated by ApoE2, ApoE3, and ApoE4 in human neurons parallels Alzheimer\u2019s disease risk","volume":"39","author":"Huang","year":"2019","journal-title":"J 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