{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:35:15Z","timestamp":1781894115786,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,10,12]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) pathology impacts the response to treatment in patients with idiopathic normal pressure hydrocephalus (iNPH), possibly through changes in resting-state functional connectivity (rs-FC). Objective: To explore the relationship between cerebrospinal fluid biomarkers of AD and the default mode network (DMN)\/hippocampal rs-FC in iNPH patients, based on their outcome after cerebrospinal fluid tap test (CSFTT), and in patients with AD. Methods: Twenty-six iNPH patients (mean age: 79.9\u00b15.9 years; 12 females) underwent MRI and clinical assessment before and after CSFTT and were classified as responders (Resp) or not (NResp), based on the improvement at the timed up and go test and walking speed. Eleven AD patients (mean age: 70.91\u00b15.2 years; 5 females), matched to iNPH for cognitive status, were also included. DMN and hippocampal rs-FC was related to amyloid-\u03b242 and phosphorylated tau (pTau) levels. Results: Lower amyloid-\u03b242 levels were associated with reduced inter- and intra-network rs-FC in NResp, and the interaction between amyloid-\u03b242 and rs-FC was a predictor of outcome after CSFTT. The rs-FC between DMN and salience networks positively correlated to amyloid-\u03b242 levels in both NResp and AD patients. The increase in the inter-network rs-FC after CSFTT was associated with higher pTau and lower amyloid-\u03b242 levels in NResp, and to lower pTau levels in Resp. Conclusion: Amyloid-\u03b242 and pTau impact on rs-FC and its changes after CSFTT in iNPH patients. The interaction between AD biomarkers and rs-FC might explain the responder status in iNPH.<\/jats:p>","DOI":"10.3233\/jad-210534","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T14:13:46Z","timestamp":1629814426000},"page":"1717-1728","source":"Crossref","is-referenced-by-count":8,"title":["Alzheimer\u2019s Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus: Linking Functional Connectivity and Clinical Outcome"],"prefix":"10.1177","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-5443","authenticated-orcid":false,"given":"Giulia","family":"Bommarito","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Van De Ville","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Center of Neuroprosthetics, Ecole Polytechnique F\u00e9d\u00e9rale De Lausanne (EPFL), Lausanne, Switzerland"},{"name":"Department of Radiology and Medical Informatics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Rehabilitation and Geriatrics, Geneva University and University Hospitals, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Garibotto","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals and NIMTlab, Geneva University, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ribaldi","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Rehabilitation and Geriatrics, Geneva University and University Hospitals, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Stampacchia","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals and NIMTlab, Geneva University, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Assal","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Allali","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland"},{"name":"Department of Neurology, Division of Cognitive & Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Griffa","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland"},{"name":"Institute of Bioengineering, Center of Neuroprosthetics, Ecole Polytechnique F\u00e9d\u00e9rale De Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210534_ref1","first-page":"4","article-title":"INPH guidelines, part II: Diagnosing idio-pathic normal-pressure hydrocephalus","volume":"57","author":"Relktin","year":"2005","journal-title":"Neurosurgery"},{"key":"10.3233\/JAD-210534_ref2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1212\/WNL.0000000000000342","article-title":"Prevalence of idiopathic normal-pressure hydrocephalus","volume":"82","author":"Jaraj","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-210534_ref3","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1212\/WNL.0000000000002193","article-title":"Practice guideline: Idiopathic normal pressure hydrocephalus: Response to shunting and predictors of response","volume":"85","author":"Halperin","year":"2015","journal-title":"Neurology"},{"key":"10.3233\/JAD-210534_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-8118-10-22","article-title":"Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. 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