{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:04:26Z","timestamp":1777395866956,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,9,28]]},"abstract":"<jats:p>Background: The differentiation of idiopathic normal pressure hydrocephalus (iNPH) from neurodegenerative diseases such as Alzheimer\u2019s disease (AD) and dementia with Lewy bodies (DLB) is often challenging because of their non-specific symptoms. Therefore, various neuroradiological markers other than ventriculomegaly have been proposed. Despite the utility of disproportionately enlarged subarachnoid-space hydrocephalus (DESH) for the appropriate selection of shunt surgery candidates, the specificity and neuropathology of this finding have not been sufficiently evaluated. Objective: Investigation of the clinicopathological features and comparison of the neuroradiological findings between DESH with postmortem neuropathological diagnoses (pDESH) and clinically-diagnosed iNPH (ciNPH) patients are the main purposes of this study. Method: In addition to the retrospective evaluation of clinicopathological information, quantitative, semiquantitative, and qualitative magnetic resonance imaging (MRI) indices were compared between pathologically-investigated 10 patients with pDESH and 10 patients with ciNPH Results: Excluding one patient with multiple cerebral infarctions, the postmortem neuropathological diagnoses of the pathologically-investigated patients were mainly neurodegenerative diseases (five AD, one DLB with AD pathologies, one DLB, one argyrophilic grain disease, and one Huntington\u2019s disease). In addition to the common neuroradiological features Conclusion: Hippocampal atrophy and deformation with temporal horn enlargement seem to be characteristic neuroradiological findings of long-standing severely demented patients with DESH and neurodegenerative diseases, mainly advanced-stage AD.<\/jats:p>","DOI":"10.3233\/jad-210535","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T14:13:36Z","timestamp":1629209616000},"page":"1199-1209","source":"Crossref","is-referenced-by-count":5,"title":["Can Medial Temporal Impairment Be an Imaging Red Flag for Neurodegeneration in Disproportionately Enlarged Subarachnoid Space Hydrocephalus?"],"prefix":"10.1177","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8849-7335","authenticated-orcid":false,"given":"Keita","family":"Sakurai","sequence":"first","affiliation":[{"name":"Department of Radiology, National Center for Geriatrics and Gerontology, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daita","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Choju Medical Institute, Fukushimura Hospital, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Inui","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Bundo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, 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