{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:43:28Z","timestamp":1788540208694,"version":"build-2803163510"},"reference-count":70,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:p>Background: Anosognosia, or unawareness of memory deficits, is a common manifestation of Alzheimer\u2019s disease (AD), but greatly variable in subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) subjects. Self-referential network (SRN) is responsible for self-referential processing and considered to be related to AD progression. Objective: Our aim is to explore connectivity changes of SRN and its interaction with memory-related network and primary sensorimotor network (SMN) in the AD spectrum. Methods: About 444 Alzheimer\u2019s Disease Neuroimaging Initiative subjects (86 cognitively normal [CN]; 156 SCD; 146 aMCI; 56 AD) were enrolled in our study. The independent component analysis (ICA) method was used to extract the SRN, SMN, and memory-related network from all subjects. The alteration of functional connectivity (FC) within SRN and its connectivity with memory-related network\/SMN were compared among four groups and further correlation analysis between altered FC and memory awareness index as well as episodic memory score were performed. Results: Compared with CN group, individuals with SCD exhibited hyperconnectivity within SRN, while aMCI and AD patients showed hypoconnectivity. Furthermore, aMCI patients and AD patients both showed the interruption of the FC between the SRN and memory-related network compared to CN group. Pearson correlation analysis showed that disruptive FC within SRN and its interaction with memory-related network were related to memory awareness index and episodic memory scores. Conclusion: In conclusion, impaired memory awareness and episodic memory in the AD spectrum are correlated to the disconnection within SRN and its interaction with memory-related network.<\/jats:p>","DOI":"10.3233\/jad-210541","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T05:00:00Z","timestamp":1625893200000},"page":"111-126","source":"Crossref","is-referenced-by-count":10,"title":["Impaired Memory Awareness and Loss Integration in Self-Referential Network Across the Progression of Alzheimer\u2019s Disease Spectrum"],"prefix":"10.1177","volume":"83","author":[{"given":"Shanshan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Neuropsychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Institute of Brain Functional Imaging, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Ge","sequence":"additional","affiliation":[{"name":"Institute of Neuropsychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Institute of Brain Functional Imaging, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Radiology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Radiology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Neuropsychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Institute of Brain Functional Imaging, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210541_ref1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1192\/bjp.171.1.47","article-title":"Prospective longitudinal study of depression and anosognosia in Alzheimer\u2019s disease","volume":"171","author":"Starkstein","year":"1997","journal-title":"Br J Psychiatry"},{"key":"10.3233\/JAD-210541_ref2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neurobiolaging.2020.06.011","article-title":"What are the neural correlates of meta-cognition and anosognosia in Alzheimer\u2019s disease? A systematic review","volume":"94","author":"Hallam","year":"2020","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210541_ref3","doi-asserted-by":"crossref","first-page":"e932","DOI":"10.1212\/WNL.0000000000005120","article-title":"Anosognosia predicts default mode network hypometabolism and clinical progression to dementia","volume":"90","author":"Therriault","year":"2018","journal-title":"Neurology"},{"key":"10.3233\/JAD-210541_ref4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ana.25649","article-title":"Evolution of anosognosia in Alzheimer\u2019s disease and its relationship to amyloid","volume":"87","author":"Hanseeuw","year":"2020","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-210541_ref5","first-page":"404","article-title":"Mild cognitive impairment","volume":"22","author":"Petersen","year":"2016","journal-title":"Continuum (Minneap Minn)"},{"key":"10.3233\/JAD-210541_ref6","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3233\/JAD-200659","article-title":"Voxelwise meta-analysis of gray matter abnormalities in mild cognitive impairment and subjective cognitive decline using activation likelihood estimation","volume":"77","author":"Chen","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210541_ref7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1474-4422(19)30368-0","article-title":"The characterisation of subjective cognitive decline","volume":"19","author":"Jessen","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210541_ref8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1474-4422(19)30368-0","article-title":"The characterisation of subjective cognitive decline","volume":"19","author":"Jessen","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210541_ref9","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1212\/WNL.0000000000005863","article-title":"Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging","volume":"91","author":"van Harten","year":"2018","journal-title":"Neurology"},{"key":"10.3233\/JAD-210541_ref10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jalz.2007.01.011","article-title":"Subjective memory complaints, education, and risk of Alzheimer\u2019s disease","volume":"3","author":"van Oijen","year":"2007","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210541_ref11","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1001\/archgenpsychiatry.2010.30","article-title":"Prediction of dementia by subjective memory impairment: Effects of severity and temporal association with cognitive impairment","volume":"67","author":"Jessen","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.3233\/JAD-210541_ref12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fnagi.2019.00307","article-title":"Distinct disruptive patterns of default mode subnetwork connectivity across the spectrum of preclinical Alzheimer\u2019s disease","volume":"11","author":"Xue","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-210541_ref13","doi-asserted-by":"crossref","first-page":"e1187","DOI":"10.4088\/JCP.16m11367","article-title":"Anosognosia is an independent predictor of conversion from mild cognitive impairment to Alzheimer\u2019s disease and is associated with reduced brain metabolism","volume":"78","author":"Gerretsen","year":"2017","journal-title":"J Clin Psychiatry"},{"key":"10.3233\/JAD-210541_ref14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuropsychologia.2017.04.002","article-title":"Memory self-awareness in the preclinical and prodromal stages of Alzheimer\u2019s disease","volume":"99","author":"Vannini","year":"2017","journal-title":"Neuropsychologia"},{"key":"10.3233\/JAD-210541_ref15","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.3233\/JAD-150141","article-title":"For a cognitive model of subjective memory awareness","volume":"48 Suppl 1","author":"Dalla Barba","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210541_ref16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/13803395.2013.789485","article-title":"Self-referential processing in Alzheimer\u2019s disease: Two different ways of processing self-knowledge?","volume":"35","author":"Kalenzaga","year":"2013","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.3233\/JAD-210541_ref17","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.neuroimage.2005.12.002","article-title":"Self-referential processing in our brain\u2013a meta-analysis of imaging studies on the self","volume":"31","author":"Northoff","year":"2006","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210541_ref18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00422-009-0350-5","article-title":"Evaluating the effective connectivity of resting state networks using conditional Granger causality","volume":"102","author":"Liao","year":"2010","journal-title":"Biol Cybern"},{"key":"10.3233\/JAD-210541_ref19","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.cortex.2011.02.011","article-title":"Altered self-referential network in resting-state amnestic type mild cognitive impairment","volume":"48","author":"Bai","year":"2012","journal-title":"Cortex"},{"key":"10.3233\/JAD-210541_ref20","doi-asserted-by":"crossref","first-page":"13170","DOI":"10.1073\/pnas.0700668104","article-title":"Electrophysiological signatures of resting state networks in the human brain","volume":"104","author":"Mantini","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-210541_ref21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ana.24462","article-title":"Anosognosia in Alzheimer disease: Disconnection between memory and self-related brain networks","volume":"78","author":"Perrotin","year":"2015","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-210541_ref22","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1002\/hbm.24775","article-title":"Anosognosia and default mode subnetwork dysfunction in Alzheimer\u2019s disease","volume":"40","author":"Antoine","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-210541_ref23","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.neurobiolaging.2015.03.006","article-title":"Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment","volume":"36","author":"Yasuno","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210541_ref24","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.nicl.2017.05.020","article-title":"Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging","volume":"15","author":"Vannini","year":"2017","journal-title":"Neuroimage Clin"},{"key":"10.3233\/JAD-210541_ref25","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.neuroimage.2011.05.028","article-title":"How is our self related to midline regions and the default-mode network?","volume":"57","author":"Qin","year":"2011","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210541_ref26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3233\/JAD-180847","article-title":"Resting state abnormalities of the default mode network in mild cognitive impairment: A systematic review and meta-analysis","volume":"70","author":"Eyler","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210541_ref27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/brain.2016.0438","article-title":"The default mode network in healthy individuals: A systematic review and meta-analysis","volume":"7","author":"Mak","year":"2017","journal-title":"Brain Connect"},{"key":"10.3233\/JAD-210541_ref28","doi-asserted-by":"crossref","first-page":"117185","DOI":"10.1016\/j.neuroimage.2020.117185","article-title":"The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study","volume":"221","author":"Chen","year":"2020","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210541_ref29","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/hbm.20920","article-title":"Reduced functional coupling in the default-mode network during self-referential processing","volume":"31","author":"van Buuren","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-210541_ref30","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neunet.2020.02.021","article-title":"Constructing large-scale cortical brain networks from scalp EEG with Bayesian nonnegative matrix factorization","volume":"125","author":"Yi","year":"2020","journal-title":"Neural Netw"},{"key":"10.3233\/JAD-210541_ref31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuropsychologia.2015.05.002","article-title":"Differential contributions of hippocampus and medial prefrontal cortex to self-projection and self-referential processing","volume":"73","author":"Kurczek","year":"2015","journal-title":"Neuropsychologia"},{"key":"10.3233\/JAD-210541_ref32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neubiorev.2020.04.007","article-title":"The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties","volume":"113","author":"Chao","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-210541_ref33","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.tics.2015.08.015","article-title":"The integrative self: How self-reference integrates perception and memory","volume":"19","author":"Sui","year":"2015","journal-title":"Trends Cogn Sci"},{"key":"10.3233\/JAD-210541_ref34","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/09658211.2017.1282517","article-title":"Source memory that encoding was self-referential: The influence of stimulus characteristics","volume":"25","author":"Durbin","year":"2017","journal-title":"Memory"},{"key":"10.3233\/JAD-210541_ref35","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tics.2004.01.004","article-title":"Cortical midline structures and the self","volume":"8","author":"Northoff","year":"2004","journal-title":"Trends Cogn Sci"},{"key":"10.3233\/JAD-210541_ref36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pneurobio.2004.03.006","article-title":"The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology","volume":"72","author":"Kringelbach","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.3233\/JAD-210541_ref37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jalz.2011.02.007","article-title":"The measurement of everyday cognition: Development and validation of a short form of the Everyday Cognition scales","volume":"7","author":"Tomaszewski Farias","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210541_ref38","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jalz.2014.09.002","article-title":"Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer\u2019s disease","volume":"11","author":"Rueda","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210541_ref39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jalz.2009.04.1234","article-title":"Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites","volume":"5","author":"Potter","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-210541_ref40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jad.2019.08.053","article-title":"Usefulness of the 15-item geriatric depression scale (GDS-15) for classifying minor and major depressive disorders among community-dwelling elders","volume":"259","author":"Shin","year":"2019","journal-title":"J Affect Disord"},{"key":"10.3233\/JAD-210541_ref41","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biopsych.2011.10.035","article-title":"Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients","volume":"71","author":"Zhu","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.3233\/JAD-210541_ref42","doi-asserted-by":"crossref","first-page":"E347","DOI":"10.1212\/WNL.0000000000007822","article-title":"Left frontal connectivity attenuates the adverse effect of entorhinal tau pathology on memory","volume":"93","author":"Neitzel","year":"2019","journal-title":"Neurology"},{"key":"10.3233\/JAD-210541_ref43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.biopsych.2012.11.007","article-title":"A treatment-resistant default mode subnetwork in major depression","volume":"74","author":"Li","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.3233\/JAD-210541_ref44","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.2967\/jnumed.116.185835","article-title":"Resting-state networks as simultaneously measured with functional MRI and PET","volume":"58","author":"Savio","year":"2017","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-210541_ref45","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.neuroimage.2009.09.029","article-title":"CSF biomarker pathology correlates with a medial temporo-parietal network affected by very mild to moderate Alzheimer\u2019s disease but not a fronto-striatal network affected by healthy aging","volume":"49","author":"Fjell","year":"2010","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210541_ref46","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn Reson Med"},{"key":"10.3233\/JAD-210541_ref47","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.neuroimage.2007.11.001","article-title":"A method for functional network connectivity among spatially independent resting-state components in schizophrenia","volume":"39","author":"Jafri","year":"2008","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210541_ref48","doi-asserted-by":"crossref","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","article-title":"BrainNet Viewer: A network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"10.3233\/JAD-210541_ref49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00002093-199601020-00003","article-title":"Impaired awareness of deficits in Alzheimer disease","volume":"10","author":"Ott","year":"1996","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-210541_ref50","doi-asserted-by":"crossref","first-page":"101687","DOI":"10.1016\/j.nicl.2019.101687","article-title":"Resting state network modularity along the prodromal late onset Alzheimer\u2019s disease continuum","volume":"22","author":"Contreras","year":"2019","journal-title":"Neuroimage Clin"},{"key":"10.3233\/JAD-210541_ref51","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1017\/S1041610214002245","article-title":"Awareness of memory deficits in subjective cognitive decline, mild cognitive impairment, Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"27","author":"Lehrner","year":"2015","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-210541_ref52","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1212\/WNL.0000000000001935","article-title":"Temporal course and pathologic basis of unawareness of memory loss in dementia","volume":"85","author":"Wilson","year":"2015","journal-title":"Neurology"},{"key":"10.3233\/JAD-210541_ref53","first-page":"753","article-title":"Low cognitive awareness, but not complaint, is a good marker of preclinical Alzheimer\u2019s disease","volume":"59","author":"Cacciamani","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-210541_ref54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13195-020-00700-8","article-title":"Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD","volume":"12","author":"Cacciamani","year":"2020","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-210541_ref55","doi-asserted-by":"crossref","first-page":"e2027472","DOI":"10.1001\/jamanetworkopen.2020.27472","article-title":"Trajectory of unawareness of memory decline in individuals with autosomal dominant Alzheimer disease","volume":"3","author":"Vannini","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.3233\/JAD-210541_ref56","doi-asserted-by":"crossref","first-page":"17m11583","DOI":"10.4088\/JCP.17m11583","article-title":"An inverse U-shaped curve of resting-state networks in individuals at high risk of Alzheimer\u2019s disease","volume":"79","author":"Ye","year":"2018","journal-title":"J Clin Psychiatry"},{"key":"10.3233\/JAD-210541_ref57","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.neuroimage.2004.11.048","article-title":"Self-referential reflective activity and its relationship with rest: A PET study","volume":"25","author":"D\u2019Argembeau","year":"2005","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-210541_ref58","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1073\/pnas.071043098","article-title":"Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function","volume":"98","author":"Gusnard","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-210541_ref59","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neubiorev.2020.01.023","article-title":"Neuroimaging the consciousness of self: Review, and conceptual-methodological framework","volume":"112","author":"Frewen","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-210541_ref60","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fnsys.2014.00230","article-title":"Optogenetic dissection of medial prefrontal cortex circuitry","volume":"8","author":"Riga","year":"2014","journal-title":"Front Syst Neurosci"},{"key":"10.3233\/JAD-210541_ref61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.neuro.30.051606.094334","article-title":"Orbitofrontal cortex and its contribution to decision-making","volume":"30","author":"Wallis","year":"2007","journal-title":"Ann Rev Neurosci"},{"key":"10.3233\/JAD-210541_ref62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1176\/appi.ajp.161.1.99","article-title":"Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: An MRI-based parcellation of the prefrontal cortex","volume":"161","author":"Ballmaier","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.3233\/JAD-210541_ref63","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neubiorev.2015.12.003","article-title":"Distinct and common aspects of physical and psychological self-representation in the brain: A meta-analysis of self-bias in facial and self-referential judgements","volume":"61","author":"Hu","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-210541_ref64","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neurobiolaging.2017.08.015","article-title":"Subjective memory complaints are associated with brain activation supporting successful memory encoding","volume":"60","author":"Hayes","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210541_ref65","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neurobiolaging.2018.10.004","article-title":"Functional signature of conversion of patients with mild cognitive impairment","volume":"74","author":"Delli Pizzi","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-210541_ref66","doi-asserted-by":"crossref","first-page":"6814","DOI":"10.1038\/s41598-019-43291-7","article-title":"Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy","volume":"9","author":"Subramaniam","year":"2019","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-210541_ref67","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/cercor\/bhz217","article-title":"Functional and pathological correlates of judgments of learning in cognitively unimpaired older adults","volume":"30","author":"d\u2019Oleire Uquillas","year":"2020","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-210541_ref68","doi-asserted-by":"crossref","first-page":"14823","DOI":"10.1038\/ncomms14823","article-title":"Lateral orbitofrontal cortex anticipates choices and integrates prior with current information","volume":"8","author":"Nogueira","year":"2017","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-210541_ref69","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.cortex.2012.09.006","article-title":"Anosognosia, autobiographical memory and self knowledge in Alzheimer\u2019s disease","volume":"49","author":"Morris","year":"2013","journal-title":"Cortex"},{"key":"10.3233\/JAD-210541_ref70","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/cercor\/bhh025","article-title":"Medial prefrontal activity predicts memory for self","volume":"14","author":"Macrae","year":"2004","journal-title":"Cereb Cortex"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-210541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:06:44Z","timestamp":1777370804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-210541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":70,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-210541","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}