{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:36:38Z","timestamp":1777905398987,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:p>Background: Long-term post-stroke cognitive impairment (PSCI) has often been overlooked, especially among patients with minor stroke or transient ischemic attack (TIA). Objective: To assess 6-year domain-specific cognitive trajectories among survivors of minor stroke or TIA and to identify possible indicators associated with cognitive trajectories, as well as long-term and incident PSCI. Methods: Eligible participants completed cognitive and clinical assessments at baseline (2 weeks after stroke) and up to 5 follow-up visits in 6 years. Mixed linear models and generalized estimating equations were adopted to analyze longitudinal data and survival analysis to explore incident PSCI, controlling for demographic, clinical, and vascular indicators. Results: The prevalence of PSCI and mortality rate ranged from 34.6% to 53.7%, and 0 to 7.7% respectively, among 244 patients. Incidence of PSCI was 21.9%. While visual memory demonstrated a significant improvement (p\u200a&lt;\u200a0.05), other cognitive domains showed a fluctuating yet stable pattern across visits (all ps\u200a&gt;\u200a0.05). Besides age, baseline IQCODE (attention: \u20130.218\u200aSD\/y, executive function: \u20130.238\u200aSD\/y, visual memory: \u20130.266\u200aSD\/y), and MoCA improvement within 1 year (visuoconstruction: 0.007\u200aSD\/y, verbal memory: 0.012\u200aSD\/y) were associated with longitudinal cognitive changes. Baseline MoCA (OR\u200a=\u200a0.66, 95% CI\u200a=\u200a[0.59\u20130.74]), MoCA improvement within 3\u20136 months (OR\u200a=\u200a0.79, 95% CI\u200a=\u200a[0.71\u20130.89], and within 1 year (OR\u200a=\u200a0.86, 95% CI\u200a=\u200a[0.76\u20130.96]) were associated with long-term PSCI, while baseline MoCA (OR\u200a=\u200a0.76, 95% CI\u200a=\u200a[0.61\u20130.96]) was also associated with incident PSCI. Conclusion: While most domains remained stable across-time, visual memory demonstrated an overall improvement. Short-term cognitive improvement could be an early indicator of long-term cognitive trajectory to identify individuals who may be resilient to PSCI.<\/jats:p>","DOI":"10.3233\/jad-210619","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:17:27Z","timestamp":1627391847000},"page":"557-568","source":"Crossref","is-referenced-by-count":11,"title":["Domain-Specific Cognitive Trajectories Among Patients with Minor Stroke or Transient Ischemic Attack in a 6-Year Prospective Asian Cohort: Serial Patterns and Indicators"],"prefix":"10.1177","volume":"83","author":[{"given":"Xuhao","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Public Health & the 2nd Affiliated Hospital of School of Medicine, Zhejiang University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddie Jun Yi","family":"Chong","sequence":"additional","affiliation":[{"name":"Memory, Ageing and Cognition Centre (MACC), Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Public Health & the 2nd Affiliated Hospital of School of Medicine, Zhejiang University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Public Health & the 2nd Affiliated Hospital of School of Medicine, Zhejiang University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health & the 2nd Affiliated Hospital of School of Medicine, Zhejiang University, China"},{"name":"Memory, Ageing and Cognition Centre (MACC), Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Chen","sequence":"additional","affiliation":[{"name":"Memory, Ageing and Cognition Centre (MACC), Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Memory, Ageing and Cognition Centre (MACC), Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-210619_ref1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1474-4422(03)00305-3","article-title":"Vascular cognitive impairment","volume":"2","author":"O\u2019Brien","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-210619_ref2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-510X(02)00260-5","article-title":"Progression of cognitive impairment after stroke: One 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