{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:07:49Z","timestamp":1777396069360,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,11,23]]},"abstract":"<jats:p>Background: Poststroke dementia (PSD) is a serious problem for stroke survivors. However, there is still limited data on the real-world state and clinical management of PSD worldwide, and several countries already have a super-aged society. Objective: We conducted a nationwide questionnaire survey to examine the real-world state and management of PSD in Japan. Methods: A survey was conducted in the top 500 Japanese hospitals regarding the number of stroke patients treated between July 2018 and August 2019. Thirteen questions regarding PSD were mailed to doctors responsible for stroke management. Results: Responses were obtained from 251 hospitals (50.2%). The chief doctors responsible for stroke management answered the questionnaires. The median numbers of patients admitted annually with stroke in the departments of neurology and neurosurgery in the hospitals were 281.0 (interquartile range [IQR], 231.8\u2013385.3) and 253.5 (IQR, 210.0\u2013335.3), respectively, and most hospitals were acute care hospitals. Executive dysfunction was the most common cognitive dysfunction (10.9%), followed by amnesia (9.5%) and apathy (4.1%). Surprisingly, many stroke survivors lived alone at home (23.7%). Montreal Cognitive Assessment was significantly uncommon compared to Mini-Mental State Examination (p\u200a&lt;\u200a0.01). Furthermore, objective evaluation tests for behavioral and psychological symptoms of dementia were not often performed. Cognitive rehabilitation treatments were performed more often and earlier than drug treatments. The first drug of choice for PSD was predominantly donepezil (79.1%), followed by galantamine (6.1%), cilostazol (4.9%), memantine (2.5%), and rivastigmine (1.8%). Conclusion: Our study provides real-world evidence for the state of clinical practice related to PSD in Japan.<\/jats:p>","DOI":"10.3233\/jad-215006","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T19:31:36Z","timestamp":1633635096000},"page":"1103-1114","source":"Crossref","is-referenced-by-count":0,"title":["A Nationwide Multi-Center Questionnaire Survey on the Real-World State and Clinical Management of Poststroke Dementia in Japan"],"prefix":"10.1177","volume":"84","author":[{"given":"Kazuo","family":"Washida","sequence":"first","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"},{"name":"Department of Medical Engineering, Faculty of Healthcare Sciences, Himeji Dokkyo University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotaka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Fukuma","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215006_ref1","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: A report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.3233\/JAD-215006_ref2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000478851","article-title":"Cognitive deficits in chronic stroke patients: Neuropsychological assessment, depression, and self-reports","volume":"29","author":"Nakling","year":"2017","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"10.3233\/JAD-215006_ref3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jagp.2017.09.022","article-title":"Baseline vascular cognitive impairment predicts the course of apathetic symptoms after stroke: The CASPER Study","volume":"26","author":"Douven","year":"2018","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-215006_ref4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/PHM.0000000000000918","article-title":"Poststroke depression: A long-term problem for stroke survivors","volume":"97","author":"Arwert","year":"2018","journal-title":"Am J Phys Med Rehabil"},{"key":"10.3233\/JAD-215006_ref5","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O\u2019Brien","year":"2015","journal-title":"Lancet"},{"key":"10.3233\/JAD-215006_ref6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/jnnp.2008.155481","article-title":"Incidence and survival of dementia in a general population of Japanese elderly: The Hisayama study","volume":"80","author":"Matsui","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-215006_ref7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"Rom\u00e1n","year":"1993","journal-title":"Neurology"},{"key":"10.3233\/JAD-215006_ref8","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1471-4159.2010.06958.x","article-title":"Experimental models of vascular dementia and vascular cognitive impairment: A systematic review","volume":"115","author":"Jiwa","year":"2010","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-215006_ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10571-015-0286-3","article-title":"Animal models of vascular cognitive impairment and dementia (VCID)","volume":"36","author":"Gooch","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-215006_ref10","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3233\/JAD-131580","article-title":"Post-stroke cognitive impairment: High prevalence and determining factors in a cohort of mild. stroke","volume":"40","author":"Jacquin","year":"2014","journal-title":"J Alzheimres Dis"},{"key":"10.3233\/JAD-215006_ref11","unstructured":"United Nations, Department of Economic and Social Affairs, population Division (2019). World Population Ageing 2019: Highlights (ST\/ESA\/SER.A\/430).."},{"key":"10.3233\/JAD-215006_ref12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000200461","article-title":"Quality of life after stroke: The importance of a good recovery","volume":"27","author":"Carod-Artal","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.3233\/JAD-215006_ref13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.maturitas.2009.09.010","article-title":"Stroke-related dementia: Rates, risk factors and implications for future research","volume":"64","author":"Pendlebury","year":"2009","journal-title":"Maturitas"},{"key":"10.3233\/JAD-215006_ref14","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(09)70236-4","article-title":"Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: A systematic review and meta-analysis","volume":"8","author":"Pendlebury","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-215006_ref15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000107102","article-title":"The combined effect of age, education, and stroke on dementia and cognitive impairment no dementia in the elderly","volume":"24","author":"De Ronchi","year":"2007","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-215006_ref16","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref17","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbadis.2016.01.015","article-title":"Stroke injury, cognitive impairment and vascular dementia","volume":"1862","author":"Kalaria","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-215006_ref18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000366471","article-title":"Vascular cognitive disorders and depression after first-ever stroke: The Fogarty-Mexico Stroke Cohort","volume":"38","author":"Arauz","year":"2014","journal-title":"Cerebrovasc Dis"},{"key":"10.3233\/JAD-215006_ref19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainresbull.2018.05.018","article-title":"Stroke, cerebrovascular diseases and vascular cognitive impairment in africa","volume":"145","author":"Akinyemi","year":"2019","journal-title":"Brain Res Bull"},{"key":"10.3233\/JAD-215006_ref20","doi-asserted-by":"crossref","first-page":"105656","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105656","article-title":"A nationwide multi-center questionnaire survey on the real-world state and issues regarding post-stroke complications in japan","volume":"30","author":"Ikeda","year":"2021","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.3233\/JAD-215006_ref21","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/ijs.12557","article-title":"Canadian stroke best practice recommendations: Mood, cognition and fatigue following stroke practice guidelines, update 2015","volume":"10","author":"Eskes","year":"2015","journal-title":"Int J Stroke"},{"key":"10.3233\/JAD-215006_ref22","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/STROKEAHA.116.015242","article-title":"Long-term risk of dementia among survivors of ischemic or hemorrhagic stroke","volume":"48","author":"Corraini","year":"2017","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1440-1630.2011.00943.x","article-title":"National survey of Canadian occupational therapists\u2019 assessment and treatment of cognitive impairment post-stroke","volume":"58","author":"Korner-Bitensky","year":"2011","journal-title":"Aust Occup Ther J"},{"key":"10.3233\/JAD-215006_ref24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12883-016-0599-y","article-title":"Living alone predicts mortality in patients with ischemic stroke before 70 years of age: A long-term prospective follow-up study","volume":"16","author":"Redfors","year":"2016","journal-title":"BMC Neurol"},{"key":"10.3233\/JAD-215006_ref25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/0891988718774425","article-title":"Living alone and dementia incidence: A clinical-based study in people with mild cognitive impairment","volume":"31","author":"Grande","year":"2018","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.3233\/JAD-215006_ref26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/jnnp.2008.166603","article-title":"Poststroke dementia predicts poor survival in long-term follow-up: Influence of prestroke cognitive decline and previous stroke","volume":"80","author":"Melkas","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-215006_ref27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/ene.12626","article-title":"Post-stroke cognitive decline: An update and perspectives for clinical research","volume":"22","author":"Brainin","year":"2015","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-215006_ref28","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.STR.0000237236.88823.47","article-title":"National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards","volume":"37","author":"Hachinski","year":"2006","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12916-017-0779-7","article-title":"Post-stroke dementia - a comprehensive review","volume":"15","author":"Mijajlovic","year":"2017","journal-title":"BMC Med"},{"key":"10.3233\/JAD-215006_ref30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.clineuro.2018.09.004","article-title":"Montreal cognitive assessment score correlates with regional cerebral blood flow in post-stroke patients","volume":"174","author":"Nakaoku","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"10.3233\/JAD-215006_ref31","doi-asserted-by":"crossref","first-page":"e046316","DOI":"10.1136\/bmjopen-2020-046316","article-title":"Screening and follow-up care for cognitive and emotional problems after transient ischaemic attack and ischaemic stroke: A national, cross-sectional, online survey among neurologists in the Netherlands","volume":"11","author":"Slenders","year":"2021","journal-title":"BMJ Open"},{"key":"10.3233\/JAD-215006_ref32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1440-1630.2008.00764.x","article-title":"Management of patients with cognitive impairment after stroke: A survey of Australian occupational therapists","volume":"56","author":"Koh","year":"2009","journal-title":"Aust Occup Ther"},{"key":"10.3233\/JAD-215006_ref33","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1161\/STROKEAHA.114.004232","article-title":"Are cognitive screening tools sensitive and specific enough for use after stroke? A systematic literature review","volume":"45","author":"Stolwyk","year":"2014","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref34","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/STROKEAHA.110.579888","article-title":"Underestimation of cognitive impairment by mini-mental state examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: A population-based study","volume":"41","author":"Pendlebury","year":"2010","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref35","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1017\/S1355617714000733","article-title":"Performance of the NINDS-CSN 5-minute protocol in a national population-based sample","volume":"20","author":"Kennedy","year":"2014","journal-title":"J Int Neuropsychol Soc"},{"key":"10.3233\/JAD-215006_ref36","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1017\/S1041610216002520","article-title":"Prediction of post-stroke dementia using ninds-csn 5-minute neuropsychology protocol in acute stroke","volume":"29","author":"Lim","year":"2017","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-215006_ref37","first-page":"CD010772","article-title":"INFORMANT QUESTIONNAIRE on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a secondary care setting","volume":"10","author":"Harrison","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-215006_ref38","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/gps.908","article-title":"Can iqcode detect poststroke dementia?","volume":"18","author":"Tang","year":"2003","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-215006_ref39","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1161\/STROKEAHA.119.028845","article-title":"Influence of preexisting cognitive impairment on clinical severity of ischemic stroke: The Dijon Stroke Registry","volume":"51","author":"Bejot","year":"2020","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref40","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1212\/WNL.0000000000007716","article-title":"Progression of cognitive decline before and after incident stroke","volume":"93","author":"Zheng","year":"2019","journal-title":"Neurology"},{"key":"10.3233\/JAD-215006_ref41","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/CLEP.S150915","article-title":"Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, andmortality: A systematic review and meta-analysis of individual participant data","volume":"10","author":"Eurelings","year":"2018","journal-title":"Clin Epidemiol"},{"key":"10.3233\/JAD-215006_ref42","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1161\/STROKEAHA.109.554410","article-title":"A longitudinal view of apathy and its impact after stroke","volume":"40","author":"Mayo","year":"2009","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1176\/appi.ajp.2015.15030363","article-title":"Post-stroke depression: A review","volume":"173","author":"Robinson","year":"2016","journal-title":"Am J Psychiatry"},{"key":"10.3233\/JAD-215006_ref44","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1161\/STR.0000000000000098","article-title":"Guidelines for adult stroke rehabilitation and recovery: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"47","author":"Winstein","year":"2016","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref45","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/13607863.2013.824406","article-title":"Effect on anxiety and depression of a multifactorial risk factor intervention program after stroke and TIA: A randomized controlled trial","volume":"18","author":"Ihle-Hansen","year":"2014","journal-title":"Aging Ment Health"},{"key":"10.3233\/JAD-215006_ref46","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/09602011.2011.582708","article-title":"Neural correlates of donepezil-induced cognitive improvement in patients with right hemisphere stroke: A pilot study","volume":"21","author":"Chang","year":"2011","journal-title":"Neuropsychol Rehabil"},{"key":"10.3233\/JAD-215006_ref47","first-page":"CD004395","article-title":"Donepezil for vascular cognitive impairment","volume":"1","author":"Malouf","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-215006_ref48","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1212\/01.wnl.0000266625.31615.f6","article-title":"Galantamine treatment of vascular dementia: A randomized trial","volume":"69","author":"Auchus","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-215006_ref49","first-page":"CD004744","article-title":"Rivastigmine for vascular cognitive impairment","author":"Birks","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-215006_ref50","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1161\/01.STR.0000020094.08790.49","article-title":"Efficacy and safety of memantine in patients with mild to moderate vascular dementia: A randomized, placebo-controlled trial (MMM 300)","volume":"33","author":"Orgogozo","year":"2002","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref51","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00004850-200211000-00005","article-title":"A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (mmm500)","volume":"17","author":"Wilcock","year":"2002","journal-title":"Int Clin Psychopharmacol"},{"key":"10.3233\/JAD-215006_ref52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/0269215518808000","article-title":"What factors affect clinical decision-making about access to stroke rehabilitation? A systematic review","volume":"33","author":"Longley","year":"2019","journal-title":"Clin Rehabil"},{"key":"10.3233\/JAD-215006_ref53","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1017\/S1041610211001980","article-title":"The effect of physical activity on cognitive function after stroke: A systematic review","volume":"24","author":"Cumming","year":"2012","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-215006_ref54","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1161\/STROKEAHA.117.017319","article-title":"Effects of physical activity on poststroke cognitive function: A meta-analysis of randomized controlled trials","volume":"48","author":"Oberlin","year":"2017","journal-title":"Stroke"},{"key":"10.3233\/JAD-215006_ref55","first-page":"CD002293","article-title":"Cognitive rehabilitation for memory deficits following stroke","volume":"18","author":"Nair","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-215006_ref56","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/jnc.14153","article-title":"The role of exercise in mitigating subcortical ischemic vascular cognitive impairment","volume":"144","author":"Dao","year":"2018","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-215006_ref57","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (finger): A randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.3233\/JAD-215006_ref58","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/ene.13684","article-title":"Multidomain intervention for the prevention of cognitive decline after stroke - a pooled patient-level data analysis","volume":"25","author":"Teuschl","year":"2018","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-215006_ref59","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jama.2018.21442","article-title":"Effect of intensive vs standard blood pressure control on probable dementia: A randomized clinical trial","volume":"321","author":"Williamson","year":"2019","journal-title":"JAMA"},{"key":"10.3233\/JAD-215006_ref60","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(13)61570-6","article-title":"A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the Cognitive Function and Ageing Study I and II","volume":"382","author":"Matthews","year":"2013","journal-title":"Lancet"},{"key":"10.3233\/JAD-215006_ref61","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1504327","article-title":"Incidence of dementia over threedecades in the Framingham Heart Study","volume":"374","author":"Satizabal","year":"2016","journal-title":"N Engl J Med"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-215006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:29Z","timestamp":1777370849000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-215006"}},"subtitle":[],"editor":[{"given":"Robert","family":"Friedland","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":61,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-215006","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}