{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:16:09Z","timestamp":1790273769533,"version":"4.1.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,1,4]]},"abstract":"<jats:p>Background: Low blood status in several nutritional compounds, including long-chain omega-3 fatty acids (LC n-3 PUFA), carotenoids, and vitamin D, have been associated with a higher risk to develop dementia. Nutritional deficiencies may potentiate each other regarding dementia risk; yet the association of multiple nutritional deficiencies with dementia has been little explored. Objective: To develop an index of micronutritional biological status (MNBS) for the screening of multi-micronutritional deficiencies associated with the risk of dementia in a prospective population-based cohort of older persons. Methods: We included participants from the Bordeaux Three-City study, who were free of dementia at baseline, had blood measurements of LC n-3 PUFA, carotenoids, and 25(OH)D, and who were followed for up to 18 years for dementia. We used penalized splines in Cox models to model dose-response relationships of each nutritional component with the risk of dementia and construct a risk index. Results: 629 participants with an average age of 73.1 years were included in the study. Each increase of 1 SD of the MNBS index was associated with a 46%higher risk of dementia (HR\u200a=\u200a1.46, 95%CI 1.23; 1.73). Participants with highest index ([mean+1SD; max]) had a 4-fold increased risk of dementia compared with participants with a low index ([min; mean-1SD]) (HR\u200a=\u200a4.17, 95%CI 2.30; 7.57). Conclusion: This index of assessment of micronutritional biological status is a practical tool that may help identify populations with inadequate nutritional status, screen eligible individuals for nutritional prevention in primary care, or for supplementation in preventive trials of dementia.<\/jats:p>","DOI":"10.3233\/jad-215011","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T11:22:05Z","timestamp":1637320925000},"page":"331-342","source":"Crossref","is-referenced-by-count":5,"title":["A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community"],"prefix":"10.1177","volume":"85","author":[{"given":"Jeanne","family":"Neuffer","sequence":"first","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Gourru","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lef\u00e8vre-Arbogast","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Foubert-Samier","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, Bordeaux Univ. Hospital, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Helmer","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Delcourt","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"F\u00e9art","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cilia","family":"Samieri","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215011_ref1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(18)30338-7","article-title":"Nutrition and prevention of cognitive impairment","volume":"17","author":"Scarmeas","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-215011_ref2","doi-asserted-by":"crossref","unstructured":"Samieri C (2018) Epidemiology and risk factors of Alzheimer\u2019s disease: A focus on diet. 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