{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:03:20Z","timestamp":1791461000664,"version":"4.3.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:p>Background: Elevated blood pressure (BP) is a risk factor for cognitive impairment. Objective: We aim to explore the association between the duration of hypertension in early adulthood, with cognitive function in midlife. Furthermore, we investigate whether this asssociation is altered among participants with controlled BP. Methods: This prospective study included 2,718 adults aged 18\u201330 years without hypertension at baseline who participated in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Duration of hypertension was calculated based on repeat measurements of BP performed at 2, 5, 7, 10, 15, 20, and 25 years after baseline. Cognitive function was assessed at Year-25 using the Rey Auditory Verbal Learning Test (RAVLT), Digit Symbol Substitution Test (DSST), and Stroop test. Results: After multivariable adjustment, a longer hypertension duration was associated with worse verbal memory (RAVLT, p trend\u200a=\u200a0.002) but not with processing speed (DSST, p trend\u200a=\u200a0.112) and executive function (Stroop test, p trend\u200a=\u200a0.975). Among subgroups of participants with controlled (BP\u200a&lt;\u200a140\/90\u200ammHg) and uncontrolled (SBP\u2265140\u200ammHg or DBP\u226590\u200ammHg) BP at the time of cognitive assessment (i.e., Year-25 BP), longer duration of hypertension was associated with worse verbal memory. Similar results were observed in subgroups with controlled and uncontrolled average BP prior to cognitive assessment. Conclusion: Longer duration of hypertension during early adulthood is associated with worse verbal memory in midlife regardless of current or long-term BP control status. The potential risk of hypertension associated cognitive decline should not be overlooked in individuals with a long duration of hypertension, even if BP levels are controlled.<\/jats:p>","DOI":"10.3233\/jad-215070","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T16:51:11Z","timestamp":1638291071000},"page":"779-789","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Hypertension Duration and Blood Pressure Control During Early Adulthood on Cognitive Function in Middle Age"],"prefix":"10.1177","volume":"85","author":[{"given":"Haobin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Huiqiao Building, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215070_ref1","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1001\/jama.1995.03530230032026","article-title":"The association between midlife blood pressure levels and late-life cognitive function. 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