{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:26:44Z","timestamp":1778203604226,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:p>Background: Accumulating studies have implicated thyroid dysfunction in the pathogenesis of Alzheimer\u2019s disease (AD). Objective: This study aimed to explore the association between thyroid hormone (TH) levels and cerebrospinal fluid (CSF) biomarkers for AD continuum among euthyroid subjects. Methods: In all, 93 clinically euthyroid subjects with a cognitive decline were included in this prospective cross-sectional study and were divided into groups with abnormal AD biomarkers (belonging to the \u201cAlzheimer\u2019s continuum\u201d; A+ patients) and those with \u201cnormal AD biomarkers\u201d or \u201cnon-AD pathological changes\u201d (A\u2013patients), according to the ATN research framework classification for AD. A partial correlation analysis of serum thyroid-stimulating hormone (TSH) or TH levels with CSF biomarkers was conducted. The predictor for A+ patients was analyzed via binary logistic regressions. Finally, the diagnostic significance of individual biochemical predictors for A+ patients was estimated via receiver operating characteristic curve analysis. Results: Serum total triiodothyronine (TT3) and free triiodothyronine (FT3) levels were found to affect the levels of CSF amyloid-\u03b2 (A\u03b2)42 and the ratios of A\u03b242\/40. Further, FT3 was found to be a significant predictor for A+ via binary logistic regression modeling. Moreover, FT3 showed a high diagnostic value for A+ in euthyroid subjects. Conclusion: Even in a clinical euthyroid state, low serum FT3 and TT3 levels appear to be differentially associated with AD-specific CSF changes. These data indicate that serum FT3 is a strong candidate for differential diagnosis between AD continuum and non-AD dementia, which benefits the early diagnosis and effective management of preclinical and clinical AD patients.<\/jats:p>","DOI":"10.3233\/jad-215092","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T16:52:14Z","timestamp":1638291134000},"page":"605-614","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Serum Triiodothyronine with Biomarkers for Alzheimer\u2019s Disease Continuum in Euthyroid Subjects"],"prefix":"10.1177","volume":"85","author":[{"given":"Feifei","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingjian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Xiao","sequence":"additional","affiliation":[{"name":"Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 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