{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:31:00Z","timestamp":1792672260949,"version":"4.5.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hallucinations in Alzheimer\u2019s disease (AD) have been linked to more severe cognitive and functional decline. However, research on visual hallucinations (VH), the most common type of hallucinations in AD, is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the cognitive and cerebral macrostructural and metabolic features associated with VH in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-four AD patients with VH, 24 with no VH (NVH), and 24 cognitively normal (CN) matched controls were selected from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) database. Differences in regional gray matter (GM) volumes and cognitive performance were investigated with whole brain voxel-based morphometry analyses of MRI structural brain scans, and analyses of neuropsychological tests. Glucose metabolic changes were explored in a sub-sample of patients who had FDG-PET scans available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>More severe visuoconstructive and attentional deficits were found in AD VH compared with NVH. GM atrophy and hypometabolism were detected in occipital and temporal areas in VH patients in comparison with CN. On the other hand, NVH patients had atrophy and hypometabolism mainly in temporal areas. No differences in GM volume and glucose metabolism were found in the direct comparison between AD VH and NVH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In addition to the pattern of brain abnormalities typical of AD, occipital alterations were observed in patients with VH compared with CN. More severe visuoconstructive and attentional deficits were found in AD VH when directly compared with NVH, and might contribute to the emergence of VH in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-215107","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T10:57:26Z","timestamp":1657882646000},"page":"133-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["A Multimodal Neuroimaging and Neuropsychological Study of Visual Hallucinations in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"89","author":[{"given":"Stefania","family":"Pezzoli","sequence":"first","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA"},{"name":"Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Manca","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Brunel University London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Cagnin","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padua, Padua, Italy"},{"name":"Padua Neuroscience Center (PNC), University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalena","family":"Venneri","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Brunel University London, London, UK"},{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13439"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.069"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.03.005"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.02.021"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.12.1983"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186886"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-199522330-00003"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0356-0"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh725"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-65"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.08.020"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200307000-00003"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190828"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.13.1.50"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00326-X"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4757"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.09.002"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1080\/13546805.2018.1443062"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1080\/13546805.2015.1023392"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1159\/000369161"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.1.25"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2006.09.025"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.03.006"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114774"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.10.1470"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X05000130"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1656515"},{"key":"ref029","doi-asserted-by":"crossref","unstructured":"PezzoliS, VenneriA (2021) Neuroimaging findings in patients with hallucinations: Evidence from neurodegenerative and psychiatric conditions. 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