{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:05:03Z","timestamp":1781712303317,"version":"3.54.5"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:p>Background: Idiopathic normal pressure hydrocephalus (iNPH) is often misdiagnosed as Alzheimer\u2019s disease (AD) due to overlapping pathophysiology and similar imaging characteristics, including ventricular enlargement and increased white matter lesions (WMLs). Objective: To compare the extent and distribution of WMLs directly between iNPH and AD and examine the association with underlying pathophysiology. Methods: Twelve patients with iNPH (mean age: 78.08 years; 5 females), 20 with AD (mean age: 75.40 years; 13 females), and 10 normal cognition (NC) participants (mean age: 76.60 years; 7 females) were recruited. The extent and distribution of WMLs and the lateral ventricular volume (LV-V) were evaluated on MRI using voxel-based morphometry analysis. Concentrations of cerebrospinal fluid biomarkers, such as amyloid-\u03b2 protein (A\u03b2)42, A\u03b240, A\u03b238, and tau species, were also measured. Risk factors for small vessel disease (SVD) were assessed by blood examination and medical records. Results: The periventricular WML volume (PWML-V) and deep WML volume (DWML-V) were significantly larger in iNPH than in AD and NC. The DWML-V was dominant in iNPH, while the PWML-V was dominant in AD and NC. GM-V was significantly smaller in AD than in iNPH and NC. The LV-V positively correlated with WML-V in all participants. There was a significant negative correlation between LV-V and A\u03b238 in iNPH. Furthermore, there was no significant difference in SVD risk factors between the groups. Conclusion: The differences in the extent and distribution of WMLs between iNPH and AD, especially predominance of DWML-V over PWML-V in iNPH, may reflect decreased fluid and A\u03b2 clearance.<\/jats:p>","DOI":"10.3233\/jad-215187","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T10:54:19Z","timestamp":1638528859000},"page":"851-862","source":"Crossref","is-referenced-by-count":10,"title":["White Matter Lesions May Aid in Differentiating Idiopathic Normal Pressure Hydrocephalus and Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"85","author":[{"given":"Takeshi","family":"Kuroda","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyasu","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Physiology, Showa University School of Medicine, Tokyo, 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