{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:38:49Z","timestamp":1792629529089,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Altered gait is a frequent feature of Alzheimer\u2019s disease (AD), as is vitamin D deficiency. Treatment with memantine and vitamin D can protect cortical axons from exposure to amyloid-\u03b2 and glutamate toxicity, suggesting this combination may mitigate altered gait in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Investigate the effects of vitamin D deprivation and subsequent treatment with memantine and vitamin D enrichment on gait performance in APPswe\/PS1dE9 mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Male APPswe\/PS1dE9 mice were split into four groups ( n\u200a=\u200a14 each) at 2.5 months of age. A control group was fed a standard diet throughout while the other three groups started a vitamin D-deficient diet at month 6. One group remained on this deficient diet for the rest of the study. At month 9, the other two groups began treatment with either memantine alone or memantine combined with 10 IU\/g of vitamin D. Gait was assessed using CatWalk at months 6, 9, 12, and 15.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Vitamin D deprivation led to a 13% increase in hind stride width by month 15 ( p\u200a&lt;\u200a0.001). Examination of the treatment groups at month 15 revealed that mice treated with memantine alone still showed an increase in hind stride width compared to controls ( p\u200a&lt;\u200a0.01), while mice treated with memantine and vitamin D did not ( p\u200a=\u200a0.21).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vitamin D deprivation led to impaired postural control in the APPswe\/PS1dE9 model. Treatment with memantine and vitamin D, but not memantine alone, prevented this impairment. Future work should explore the potential for treatments incorporating vitamin D supplementation to improve gait in people with AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-215188","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T10:29:23Z","timestamp":1640341763000},"page":"1755-1766","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Memantine and High Dose Vitamin D on Gait in Male APP\/PS1 Alzheimer\u2019s Disease Mice Following Vitamin D Deprivation"],"prefix":"10.1177","volume":"85","author":[{"given":"Dana N.","family":"Broberg","sequence":"first","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada"},{"name":"Department of Medical Biophysics, University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dickson","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada"},{"name":"Department of Medical Biophysics, University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Bellyou","sequence":"additional","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero-Odasso","sequence":"additional","affiliation":[{"name":"Department of Medicine and Division of Geriatric Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"},{"name":"Gait and Brain Lab, Parkwood Institute, Lawson Health Research 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bartha","sequence":"additional","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada"},{"name":"Department of Medical Biophysics, University of Western Ontario, London, ON, 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of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium (2011) Dietary reference intakes for calcium and vitamin D. In The National Academies Collection: Reports funded by National Institutes of Health, Ross AC, Taylor CL, Yaktine AL, Del Valle HB, eds. 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