{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:09:56Z","timestamp":1790467796074,"version":"4.1.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:p>Background: There is no consensus regarding the diagnostic value of cerebrospinal fluid (CSF) Alzheimer\u2019s disease (AD) biomarkers in cerebral amyloid angiopathy (CAA). Objective: To describe the CSF levels of A\u03b242, A\u03b240, total protein Tau, and phosphorylated-Tau (p-Tau) in a large series of probable CAA patients and to compare with AD patients in order to identify a specific pattern in CAA but also to look for correlations with the neuroimaging profile. Methods: We retrospectively included from 2 French centers probable CAA patients according to modified Boston criteria who underwent lumbar puncture (LP) with CSF AD biomarker quantifications. Two neurologists independently analyzed all MRI sequences. A logistic regression and Spearman\u2019s correlation coefficient were used to identify correlation between MRI and CSF biomarkers in CAA. Results: We included 63 probable CAA and 27 AD patients. Among CAA 50.8% presented with decreased A\u03b242 level associated with elevated p-Tau and\/or Tau, 34.9% with isolated decreased A\u03b242 level and 14.3% patients with normal A\u03b242 level. Compared to AD, CAA showed lower levels of Tau (p\u200a=\u200a0.008), p-Tau (p\u200a=\u200a0.004), and A\u03b240 (p\u200a=\u200a0.001) but similar A\u03b242 level (p\u200a=\u200a0.07). No correlation between A\u03b242 or A\u03b240 levels and neuroimaging was found. Conclusion: CSF biomarkers may improve the accuracy of the modified Boston criteria with altered profile in 85% of the patients fulfilling revised Boston criteria for probable CAA. A\u03b240 appears as an interesting selective biomarker in differential diagnosis.<\/jats:p>","DOI":"10.3233\/jad-215208","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T12:03:21Z","timestamp":1648814601000},"page":"791-802","source":"Crossref","is-referenced-by-count":27,"title":["Cerebrospinal Fluid Profile of Tau, Phosphorylated Tau, A\u03b242, and A\u03b240 in Probable Cerebral Amyloid Angiopathy"],"prefix":"10.1177","volume":"87","author":[{"given":"Lou","family":"Grangeon","sequence":"first","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245 and CHURouen, Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[{"name":"CMRR Paris Nord AP-HP, Groupe Hospitalier Lariboisi\u00e8re Fernand-Widal Saint-Louis, INSERM, U942, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 942, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Guey","sequence":"additional","affiliation":[{"name":"Department of Neurology, AP-HP, Groupe Hospitalier Lariboisi\u00e8re Fernand-Widal Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Zarea","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245 and CHURouen, Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Martinaud","sequence":"additional","affiliation":[{"name":"Department of Neurology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Rotharmel","sequence":"additional","affiliation":[{"name":"Rouvray Hospital of Rouen, University Department of Psychiatry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Malt\u00eate","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245 and CHURouen, Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Quillard-Muraine","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, CHU Rouen, Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gael","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245 and CHU Rouen, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Charbonnier","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245 and CHU Rouen, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Chabriat","sequence":"additional","affiliation":[{"name":"Department of Neurology, AP-HP, Groupe Hospitalier Lariboisi\u00e8re Fernand-Widal Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wallon","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245 and CHURouen, Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215208_ref1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease\u2014one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-215208_ref2","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat Rev Dis Primer"},{"key":"10.3233\/JAD-215208_ref3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s11883-003-0048-4","article-title":"Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston criteria","volume":"5","author":"Smith","year":"2003","journal-title":"Curr Atheroscler Rep"},{"key":"10.3233\/JAD-215208_ref4","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1212\/WNL.0b013e3181dad605","article-title":"Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy","volume":"74","author":"Linn","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-215208_ref5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1212\/WNL.56.4.537","article-title":"Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria","volume":"56","author":"Knudsen","year":"2001","journal-title":"Neurology"},{"key":"10.3233\/JAD-215208_ref6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1212\/01.wnl.0000438225.02729.04","article-title":"White matter perivascular spaces: An MRI marker in pathology-proven cerebral amyloid angiopathy?","volume":"82","author":"Charidimou","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-215208_ref7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/STROKEAHA.117.016990","article-title":"Diagnosis of cerebral amyloid angiopathy: Evolution of the Boston criteria","volume":"49","author":"Greenberg","year":"2018","journal-title":"Stroke"},{"key":"10.3233\/JAD-215208_ref8","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jalz.2015.04.009","article-title":"Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage","volume":"11","author":"Martinez-Ramirez","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215208_ref9","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1212\/WNL.0000000000005030","article-title":"Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis","volume":"90","author":"Charidimou","year":"2018","journal-title":"Neurology"},{"key":"10.3233\/JAD-215208_ref10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00415-013-7160-3","article-title":"Impact of cerebro-spinal fluid biomarkers of Alzheimer\u2019s disease in clinical practice: A multicentric study","volume":"261","author":"Mouton-Liger","year":"2014","journal-title":"J Neurol"},{"key":"10.3233\/JAD-215208_ref11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3233\/JAD-121549","article-title":"Impact of the 2008-2012 French Alzheimer Plan on the use of cerebrospinal fluid biomarkers in research memory center: The PLM Study","volume":"34","author":"Gabelle","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215208_ref12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1474-4422(16)00070-3","article-title":"CSF and blood biomarkers for the diagnosis of Alzheimer\u2019s disease: A systematic review and meta-analysis","volume":"15","author":"Olsson","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-215208_ref13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cca.2019.03.001","article-title":"The added value of A\u03b242\/A\u03b240 in the CSF signature for routine diagnostics of Alzheimer\u2019s disease","volume":"494","author":"Biscetti","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.3233\/JAD-215208_ref14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13195-015-0114-5","article-title":"Cerebrospinal fluid amyloid-\u03b2 42\/40 ratio in clinical setting of memory centers: A multicentric study","volume":"7","author":"Dumurgier","year":"2015","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-215208_ref15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jns.2017.07.015","article-title":"Hemorrhage recurrence risk factors in cerebral amyloid angiopathy: Comparative analysis of the overall small vessel disease severity score versus individual neuroimaging markers","volume":"380","author":"Boulouis","year":"2017","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-215208_ref16","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1161\/STROKEAHA.114.005568","article-title":"White matter perivascular spaces are related to cortical superficial siderosis in cerebral amyloid angiopathy","volume":"45","author":"Charidimou","year":"2014","journal-title":"Stroke"},{"key":"10.3233\/JAD-215208_ref17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fneur.2019.00439","article-title":"Decreased CSF levels of \u00df-amyloid in patients with cortical superficial siderosis","volume":"10","author":"Catak","year":"2019","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-215208_ref18","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neurol.2020.02.001","article-title":"Clinical features related to CSF level of amyloid A\u03b242 and A\u03b240 proteins in presence of lobar microbleeds","volume":"176","author":"Girard-Stein","year":"2020","journal-title":"Rev Neurol (Paris)"},{"key":"10.3233\/JAD-215208_ref19","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/jcbfm.2015.25","article-title":"Cerebral amyloid angiopathy-related atraumatic convexal subarachnoid hemorrhage: An ARIA before the tsunami","volume":"35","author":"Mart\u00ednez-Lizana","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.3233\/JAD-215208_ref20","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3233\/JAD-160400","article-title":"Cerebrospinal fluid Alzheimer\u2019s disease biomarkers in isolated supratentorial cortical superficial siderosis","volume":"54","author":"Renard","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215208_ref21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/ana.21694","article-title":"Cerebrospinal fluid amyloid \u03b240 is decreased in cerebral amyloid angiopathy","volume":"66","author":"Verbeek","year":"2009","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-215208_ref22","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1161\/STROKEAHA.112.657759","article-title":"Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: Multicentre magnetic resonance imaging cohort study and meta-analysis","volume":"43","author":"Charidimou","year":"2012","journal-title":"Stroke"},{"key":"10.3233\/JAD-215208_ref23","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3233\/JAD-150621","article-title":"Cerebrospinal fluid Alzheimer\u2019s disease biomarkers in cerebral amyloid angiopathy-related inflammation","volume":"50","author":"Renard","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215208_ref24","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jalz.2018.05.004","article-title":"Cerebrospinal fluid tau, A\u03b2, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration","volume":"14","author":"Alosco","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215208_ref25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3233\/JAD-2000-23-402","article-title":"Cerebrospinal fluid markers for Alzheimer\u2019s disease evaluated after acute ischemic stroke","volume":"2","author":"Hesse","year":"2000","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215208_ref26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215208_ref27","doi-asserted-by":"crossref","first-page":"S390","DOI":"10.1016\/j.jalz.2013.06.008","article-title":"Impact of harmonization of collection tubes on Alzheimer\u2019s disease diagnosis","volume":"10","author":"Lehmann","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215208_ref28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/alzrt267","article-title":"A diagnostic scale for Alzheimer\u2019s disease based on cerebrospinal fluid biomarker profiles","volume":"6","author":"Lehmann","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-215208_ref29","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/jnnp-2020-323951","article-title":"Cerebral microbleeds: From depiction to interpretation","volume":"92","author":"Puy","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-215208_ref30","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/brain\/awv162","article-title":"Cortical superficial siderosis: Detection and clinical significance in cerebral amyloid angiopathy and related conditions","volume":"138","author":"Charidimou","year":"2015","journal-title":"Brain"},{"key":"10.3233\/JAD-215208_ref31","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/jnnp.55.10.967","article-title":"Atrophy of medial temporal lobes on MRI in \u201cprobable\u201d Alzheimer\u2019s disease and normal ageing: Diagnostic value and neuropsychological correlates","volume":"55","author":"Scheltens","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-215208_ref32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000049147","article-title":"CT and MRI rating of white matter lesions","volume":"13","author":"Fazekas","year":"2002","journal-title":"Cerebrovasc Dis"},{"key":"10.3233\/JAD-215208_ref33","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1468-1331.2010.03040.x","article-title":"EFNS guidelines for the diagnosis and management of Alzheimer\u2019s disease: EFNS guidelines for Alzheimer\u2019s disease","volume":"17","author":"Hort","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-215208_ref34","first-page":"838","article-title":"[Consensus 2012\u2013diagnosis and treatment of patients with dementia in Switzerland]","volume":"9","author":"Monsch","year":"2013","journal-title":"Rev Med Suisse"},{"key":"10.3233\/JAD-215208_ref35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00005072-199804000-00008","article-title":"Progression of cerebral amyloid angiopathy: Accumulation of amyloid-beta40 in affected vessels","volume":"57","author":"Alonzo","year":"1998","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-215208_ref36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0361-9230(03)00087-X","article-title":"Advances in the development of biomarkers for Alzheimer\u2019s disease: From CSF total tau and Abeta(1-42) proteins to phosphorylated tau protein","volume":"61","author":"Hampel","year":"2003","journal-title":"Brain Res Bull"},{"key":"10.3233\/JAD-215208_ref37","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.neurobiolaging.2015.06.028","article-title":"Cerebral amyloid angiopathy and its co-occurrence with Alzheimer\u2019s disease and other cerebrovascular neuropathologic changes","volume":"36","author":"Brenowitz","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-215208_ref38","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1212\/WNL.0000000000002175","article-title":"Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons","volume":"85","author":"Boyle","year":"2015","journal-title":"Neurology"},{"key":"10.3233\/JAD-215208_ref39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1474-4422(14)70003-1","article-title":"Outcome markers for clinical trials in cerebral amyloid angiopathy","volume":"13","author":"Greenberg","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-215208_ref40","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"10.3233\/JAD-215208_ref41","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/jnen\/62.12.1287","article-title":"Vascular pathology in Alzheimer disease: Correlation of cerebral amyloid angiopathy and arteriosclerosis\/lipohyalinosis with cognitive decline","volume":"62","author":"Thal","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-215208_ref42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3233\/JAD-150241","article-title":"Capillary amyloid-\u03b2 protein deposition in a population-based study (Vantaa 85+)","volume":"49","author":"M\u00e4kel\u00e4","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215208_ref43","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1001\/archneurol.2010.178","article-title":"Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP","volume":"67","author":"Bugiani","year":"2010","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-215208_ref44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jalz.2014.02.004","article-title":"Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer\u2019s disease","volume":"11","author":"Blennow","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215208_ref45","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1001\/jamaneurol.2015.1285","article-title":"Longitudinal cerebrospinal fluid biomarker changes in preclinical Alzheimer disease during middle age","volume":"72","author":"Sutphen","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-215208_ref46","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/brain\/awy050","article-title":"Data-driven models of dominantly-inherited Alzheimer\u2019s disease progression","volume":"141","author":"Oxtoby","year":"2018","journal-title":"Brain"},{"key":"10.3233\/JAD-215208_ref47","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3233\/JAD-191254","article-title":"Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy","volume":"74","author":"Banerjee","year":"2020","journal-title":"J Alzheimers Dis"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-215208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:42Z","timestamp":1777370742000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-215208"}},"subtitle":[],"editor":[{"given":"Mana","family":"Shams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":47,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-215208","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,17]]}}}