{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:33:53Z","timestamp":1784547233138,"version":"3.55.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:p>Background: In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated. Objective: To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer\u2019s disease. Method: Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish. Results: Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review. Conclusion: The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.<\/jats:p>","DOI":"10.3233\/jad-215224","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T14:00:19Z","timestamp":1648562419000},"page":"519-528","source":"Crossref","is-referenced-by-count":26,"title":["Relationship Between the Gut Microbiota and Alzheimer\u2019s Disease: A Systematic Review"],"prefix":"10.1177","volume":"87","author":[{"given":"Elisa Marina","family":"Gonz\u00e1lez Cordero","sequence":"first","affiliation":[{"name":"Universidad Francisco de Vitoria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Cuevas-Budhart","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Nefrol\u00f3gicas, Centro M\u00e9dico Nacional Siglo XXI. 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