{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:42:43Z","timestamp":1785372163520,"version":"3.55.0"},"reference-count":74,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:p>Background: The temporal relationship between sleep, Alzheimer\u2019s disease (AD), and cognitive impairment remains to be further elucidated. Objective: First, we aim to determine whether the Neuropsychiatric Inventory\u2013Questionnaire (NPI-Q) assessed nighttime behaviors prior to cognitive decline influence the rate of cognitive deterioration in pathologically confirmed AD, and second, to assess the possible interactions with APOE allele and cerebral amyloid angiopathy (CAA). Methods: The rate of cognitive decline between cognitively asymptomatic participants from the National Alzheimer Coordinating Center who eventually received a neuropathologic diagnosis of AD with (+NTB) or without (\u2212NTB) nighttime behaviors were compared using independent samples t-test. Participants were stratified by APOE carrier and CAA status. Demographic and patient characteristics were assessed using descriptive statistics, and the independent samples t-test was used for continuous variables and chi-square test for categorical variables. The significance level was set at p\u22640.05. Results: The rate of cognitive decline was greater in +NTB (n\u200a=\u200a74; 3.30 points\/year) than \u2212NTB (n\u200a=\u200a330; 2.45 points\/year) (p\u200a=\u200a0.016), even if there was no difference in cognitive status at onset. This difference was restricted to APOE \u025b4 carriers (p\u200a=\u200a0.049) and positive CAA participants (p\u200a=\u200a0.020). Significance was not reached in non-carriers (p\u200a=\u200a0.186) and negative CAA (p\u200a=\u200a0.364). APOE and CAA were not differentially distributed between the NTB groups. Conclusion: NPI-Q assessed nighttime behaviors, a surrogate for sleep disturbances, are associated with more rapidly deteriorating cognition in patients with AD neuropathology who are also carriers of APOE \u025b4 or show CAA.<\/jats:p>","DOI":"10.3233\/jad-215276","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T13:27:56Z","timestamp":1644931676000},"page":"1137-1147","source":"Crossref","is-referenced-by-count":10,"title":["Neuropsychiatric Inventory\u2013Questionnaire Assessed Nighttime Behaviors in Cognitively Asymptomatic Patients with Pathologically Confirmed Alzheimer\u2019s Disease Predict More Rapid Cognitive Deterioration"],"prefix":"10.1177","volume":"86","author":[{"given":"Adrienne L.","family":"Atayde","sequence":"first","affiliation":[{"name":"Keenan Research Centre for Biomedical Research, the Li Ka Shing Knowledge Institute, St.Michael\u2019s Hospital, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Research, the Li Ka Shing Knowledge Institute, St.Michael\u2019s Hospital, Toronto, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, Canada"},{"name":"Faculty of Medicine, Department of Psychiatry, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom A.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Research, the Li Ka Shing Knowledge Institute, St.Michael\u2019s Hospital, Toronto, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, Canada"},{"name":"Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada"},{"name":"Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Canada"},{"name":"Division of Neurosurgery, St. Michael\u2019s Hospital, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Munoz","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Research, the Li Ka Shing Knowledge Institute, St.Michael\u2019s Hospital, Toronto, Canada"},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada"},{"name":"Division of Pathology, Unity Health Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215276_ref1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tins.2016.05.002","article-title":"Sleep: A novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer\u2019s disease?","volume":"39","author":"Mander","year":"2016","journal-title":"Trends Neurosci"},{"key":"10.3233\/JAD-215276_ref2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jalz.2011.05.2410","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease","volume":"7","author":"Lyketsos","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215276_ref3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0304-3940(94)90841-9","article-title":"Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans","volume":"166","author":"Dijk","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-215276_ref4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/npp.2017.294","article-title":"Neuronal mechanisms for sleep\/wake regulation and modulatory drive","volume":"43","author":"Eban-Rothschild","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.3233\/JAD-215276_ref5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2165\/00023210-200115100-00004","article-title":"Sleep disturbances in patients with Alzheimer\u2019s disease: Epidemiology, pathophysiology and treatment","volume":"15","author":"Vitiello","year":"2001","journal-title":"CNS Drugs"},{"key":"10.3233\/JAD-215276_ref6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.sleep.2004.12.005","article-title":"Sleep disturbance in mild to moderate Alzheimer\u2019s disease","volume":"6","author":"Moran","year":"2005","journal-title":"Sleep Med"},{"key":"10.3233\/JAD-215276_ref7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1001\/jamaneurol.2017.4719","article-title":"Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease","volume":"75","author":"Musiek","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-215276_ref8","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.aah4968","article-title":"Mechanisms linking circadian clocks, sleep, and neurodegeneration","volume":"354","author":"Musiek","year":"2016","journal-title":"Science"},{"issue":"Suppl 2","key":"10.3233\/JAD-215276_ref9","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.neurobiolaging.2014.03.035","article-title":"Amyloid-\u03b2 diurnal pattern: Possible role of sleep in Alzheimer\u2019s disease pathogenesis","volume":"35","author":"Lucey","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-215276_ref10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nn.4048","article-title":"How amyloid, sleep and memory connect","volume":"18","author":"Lucey","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.3233\/JAD-215276_ref11","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"5 Suppl 6","key":"10.3233\/JAD-215276_ref12","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1212\/WNL.48.5_Suppl_6.30S","article-title":"Alzheimer\u2019s disease: Clinical implications of the apolipoprotein E genotype","volume":"48","author":"Farlow","year":"1997","journal-title":"Neurology"},{"key":"10.3233\/JAD-215276_ref13","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimerdisease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.3233\/JAD-215276_ref14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1196\/annals.1297.005","article-title":"The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: Modification by age, sex, and APOE polymorphism","volume":"1019","author":"Corder","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.3233\/JAD-215276_ref15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer\u2019s disease: Pathways, pathogenesis and therapy","volume":"10","author":"Bu","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-215276_ref16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2174\/1567205014666170220150021","article-title":"Gender and pathology-specific effect of apolipoprotein E genotype on psychosis in Alzheimer\u2019s disease","volume":"14","author":"Kim","year":"2017","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-215276_ref17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/1567205014666170829114346","article-title":"Association between psychosis phenotype and APOE genotype on the clinical profiles of Alzheimer\u2019s disease","volume":"15","author":"Qian","year":"2018","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-215276_ref18","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3233\/JAD-190643","article-title":"APOE \u025b4\/\u025b4 is associated with aberrant motor behavior through both lewy body and cerebral amyloid angiopathy pathology in high Alzheimer\u2019s disease pathological load","volume":"72","author":"Garcia-Segura","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215276_ref19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/YPG.0b013e32834dc438","article-title":"The role of PGC-1 and Apo\u025b4 in insomnia","volume":"22","author":"Wang","year":"2012","journal-title":"Psychiatr Genet"},{"key":"10.3233\/JAD-215276_ref20","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1212\/01.WNL.0000134671.99649.32","article-title":"APOE epsilon4 is associated with obstructive sleep apnea\/hypopnea: The Sleep Heart Health Study","volume":"63","author":"Gottlieb","year":"2004","journal-title":"Neurology"},{"key":"10.3233\/JAD-215276_ref21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1212\/01.wnl.0000265818.88703.83","article-title":"APOE epsilon 4 allele, cognitive dysfunction, and obstructive sleep apnea in children","volume":"69","author":"Gozal","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-215276_ref22","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.sleep.2007.10.015","article-title":"The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea","volume":"9","author":"Cosentino","year":"2008","journal-title":"Sleep Med"},{"key":"10.3233\/JAD-215276_ref23","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1152\/ajpregu.00025.2012","article-title":"Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia","volume":"303","author":"Kaushal","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.3233\/JAD-215276_ref24","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1212\/01.wnl.0000173055.75950.bf","article-title":"Nocturnal sleep apnea\/hypopnea is associated with lower memory performance in APOE epsilon4 carriers","volume":"65","author":"O\u2019Hara","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-215276_ref25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1532-5415.2007.01506.x","article-title":"Sleep-disordered breathing and cognition in older women","volume":"56","author":"Spira","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-215276_ref26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000256662","article-title":"The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons","volume":"34","author":"Boyle","year":"2010","journal-title":"Neuroepidemiology"},{"key":"10.3233\/JAD-215276_ref27","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1001\/jamaneurol.2013.4215","article-title":"Modification of the relationship of the apolipoprotein E \u025b4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep","volume":"70","author":"Lim","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-215276_ref28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10571-016-0334-7","article-title":"The science of vascular contributions to cognitive impairment and dementia (VCID): A framework for advancing research priorities in the cerebrovascular biology of cognitive decline","volume":"36","author":"Corriveau","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-215276_ref29","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jalz.2017.07.755","article-title":"Concomitant vascular and neurodegenerative pathologies double the risk of dementia","volume":"14","author":"Azarpazhooh","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215276_ref30","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3233\/JAD-160780","article-title":"Risk factors and pathological substrates associated withagitation\/aggression in Alzheimer\u2019s disease: A preliminary study using NACC data","volume":"55","author":"Sennik","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215276_ref31","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/jnnp-2013-306485","article-title":"APOE associations with severe CAA-associated vasculopathic changes: Collaborative meta-analysis","volume":"85","author":"Rannikm\u00e4e","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-215276_ref32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00401-016-1580-y","article-title":"Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer\u2019s disease","volume":"132","author":"Shinohara","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-215276_ref33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/jnnp-2018-318445","article-title":"Advanced cerebral amyloid angiopathy andsmall vessel disease are associated with psychosis in Alzheimer\u2019s disease","volume":"90","author":"Vik-Mo","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-215276_ref34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-215276_ref35","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease","volume":"56","author":"Hyman","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-215276_ref36","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.3233\/JAD-215276_ref37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1176\/jnp.12.2.233","article-title":"Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory","volume":"12","author":"Kaufer","year":"2000","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.3233\/JAD-215276_ref38","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/B978-0-444-52006-7.00041-1","article-title":"Normal and abnormal sleep in the elderly","volume":"98","author":"Cooke","year":"2011","journal-title":"Handb Clin Neurol"},{"key":"10.3233\/JAD-215276_ref39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/smrv.2002.0186","article-title":"Epidemiology of insomnia: What we know and what we still need to learn","volume":"6","author":"Ohayon","year":"2002","journal-title":"Sleep Med Rev"},{"key":"10.3233\/JAD-215276_ref40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.9758\/cpn.2017.15.2.89","article-title":"Role of sleep disturbance in the trajectory of Alzheimer\u2019s disease","volume":"15","author":"Kang","year":"2017","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"10.3233\/JAD-215276_ref41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41386-019-0478-5","article-title":"Bidirectional relationship between sleep and Alzheimer\u2019s disease: Role of amyloid,tau, and other factors","volume":"45","author":"Wang","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.3233\/JAD-215276_ref42","first-page":"108","article-title":"Predictors of mortality and institutionalization in Alzheimer disease patients 1 year after discharge from an Alzheimer dementia unit","volume":"6","author":"Bianchetti","year":"1995","journal-title":"Dementia"},{"key":"10.3233\/JAD-215276_ref43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000335363","article-title":"Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: A multicenter Italian clinical cross-sectional study on 431 patients","volume":"33","author":"Guarnieri","year":"2012","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-215276_ref44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/geronb\/gbn037","article-title":"Self-reported sleep quality predicts poor cognitive performance in healthy older adults","volume":"64","author":"Nebes","year":"2009","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10.3233\/JAD-215276_ref45","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s12603-010-0052-7","article-title":"Sleep disorders in aging and dementia","volume":"14","author":"Bombois","year":"2010","journal-title":"J Nutr Health Aging"},{"key":"10.3233\/JAD-215276_ref46","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1038\/s41467-021-22354-2","article-title":"Association of sleep duration in middle and old age with incidence of dementia","volume":"12","author":"Sabia","year":"2021","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-215276_ref47","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.5665\/sleep.2070","article-title":"Excessive sleepiness is predictive of cognitive decline in the elderly","volume":"35","author":"Jaussent","year":"2012","journal-title":"Sleep"},{"key":"10.3233\/JAD-215276_ref48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/gerona\/61.4.405","article-title":"Poor sleep is associated with impaired cognitive function in older women: The study of osteoporotic fractures","volume":"61","author":"Blackwell","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3233\/JAD-215276_ref49","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.5665\/SLEEP.1276","article-title":"Association of sleep characteristics and cognition in older community-dwelling men: The MrOS Sleep Study","volume":"34","author":"Blackwell","year":"2011","journal-title":"Sleep"},{"key":"10.3233\/JAD-215276_ref50","doi-asserted-by":"crossref","first-page":"491","DOI":"10.5665\/sleep.1732","article-title":"Sleep quality and 1-yearincident cognitive impairment in community-dwelling older adults","volume":"35","author":"Potvin","year":"2012","journal-title":"Sleep"},{"key":"10.3233\/JAD-215276_ref51","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/jamaneurol.2013.2334","article-title":"Sleep quality and preclinical Alzheimer disease","volume":"70","author":"Ju","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-215276_ref52","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1038\/emm.2014.121","article-title":"Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease","volume":"47","author":"Musiek","year":"2015","journal-title":"Exp Mol Med"},{"key":"10.3233\/JAD-215276_ref53","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jalz.2012.12.001","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease: Past progress and anticipation of the future","volume":"9","author":"Geda","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215276_ref54","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/ana.22468","article-title":"Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women","volume":"70","author":"Tranah","year":"2011","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-215276_ref55","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1172\/JCI70317","article-title":"Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration","volume":"123","author":"Musiek","year":"2013","journal-title":"J Clin Invest"},{"key":"10.3233\/JAD-215276_ref56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1212\/WNL.0000000000004171","article-title":"Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults","volume":"89","author":"Sprecher","year":"2017","journal-title":"Neurology"},{"key":"10.3233\/JAD-215276_ref57","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn.4035","article-title":"\u03b2-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation","volume":"18","author":"Mander","year":"2015","journal-title":"Nat. Neurosci"},{"key":"10.3233\/JAD-215276_ref58","doi-asserted-by":"crossref","first-page":"150ra.122","DOI":"10.1126\/scitranslmed.3004291","article-title":"Disruption of the sleep-wake cycle and diurnal fluctuation of amyloid-\u03b2 in mice with Alzheimer\u2019s disease pathology","volume":"4","author":"Roh","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.3233\/JAD-215276_ref59","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science"},{"key":"10.3233\/JAD-215276_ref60","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.3233\/JAD-215276_ref61","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1001\/jamaneurol.2014.1173","article-title":"Effect of 1 night of total sleep deprivation on cerebrospinal fluid \u03b2-amyloid 42 in healthy middle-aged men","volume":"71","author":"Ooms","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-215276_ref62","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/brain\/awx148","article-title":"Slow wave sleep disruption increases cerebrospinal fluid amyloid-\u03b2 levels","volume":"140","author":"Ju","year":"2017","journal-title":"Brain"},{"key":"10.3233\/JAD-215276_ref63","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1001\/jama.285.22.2888","article-title":"Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults","volume":"285","author":"Kadotani","year":"2001","journal-title":"JAMA"},{"key":"10.3233\/JAD-215276_ref64","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1212\/WNL.0000000000003255","article-title":"Evidence of association between sleep quality and APOE \u025b4 inhealthy older adults: A pilot study","volume":"87","author":"Drogos","year":"2016","journal-title":"Neurology"},{"key":"10.3233\/JAD-215276_ref65","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2174\/156720512800107609","article-title":"Disturbed sleep patterns in elders with mild cognitive impairment: The role of memory decline and ApoE \u025b4 genotype","volume":"9","author":"Hita-Ya\u00f1ez","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-215276_ref66","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.sleep.2018.09.001","article-title":"Mild cognitive impairment: Associations with sleep disturbance, apolipoprotein e4, and sleep medications","volume":"52","author":"Burke","year":"2018","journal-title":"Sleep Med"},{"key":"10.3233\/JAD-215276_ref67","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1194\/jlr.R075481","article-title":"Apolipoprotein E and Alzheimer\u2019s disease: The influence of apolipoprotein E on amyloid-\u03b2 and other amyloidogenic proteins","volume":"58","author":"Huynh","year":"2017","journal-title":"J Lipid Res"},{"key":"10.3233\/JAD-215276_ref68","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3233\/JAD-210272","article-title":"Associations of neuropsychiatric features with cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration in dementia with Lewy bodies compared with Alzheimer\u2019s disease and cognitively healthy people","volume":"81","author":"De Oliveira","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215276_ref69","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ana.25123","article-title":"Person-specific contribution of neuropathologies to cognitive loss in old age","volume":"83","author":"Boyle","year":"2018","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-215276_ref70","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smrv.2017.06.010","article-title":"Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis","volume":"40","author":"Shi","year":"2018","journal-title":"Sleep Med Rev"},{"key":"10.3233\/JAD-215276_ref71","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3233\/JAD-190907","article-title":"Neuropsychiatric Inventory-assessed nighttime behavior accompanies, but does not precede, progressive cognitive decline independent of Alzheimer\u2019s disease histopathology","volume":"74","author":"Atayde","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215276_ref72","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2217\/nmt.14.33","article-title":"The sleep\u2013wake cycle and Alzheimer\u2019s disease: What do we know?","volume":"4","author":"Lim","year":"2014","journal-title":"Neurodegener Dis Manag"},{"key":"10.3233\/JAD-215276_ref73","first-page":"CD009178","article-title":"Pharmacotherapies for sleep disturbances in dementia","volume":"11","author":"Mccleery","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-215276_ref74","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/157015908784533860","article-title":"Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD)","volume":"6","author":"Liperoti","year":"2008","journal-title":"Curr Neuropharmacol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-215276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:20Z","timestamp":1777370720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-215276"}},"subtitle":[],"editor":[{"given":"Andr\u00e9e-Ann","family":"Baril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":74,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-215276","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]}}}