{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:19Z","timestamp":1787169679825,"version":"build-2736575974"},"reference-count":118,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,3,8]]},"abstract":"<jats:p>African American\/Black adults are twice as likely to have Alzheimer\u2019s disease (AD) compared to non-Hispanic White adults. Genetics partially contributes to this disparity in AD risk, among other factors, as there are several genetic variants associated with AD that are more prevalent in individuals of African or European ancestry. The phospholipid-transporting ATPase ABCA7 (ABCA7) gene has stronger associations with AD risk in individuals with African ancestry than in individuals with European ancestry. In fact, ABCA7 has been shown to have a stronger effect size than the apolipoprotein E (APOE) \u025b4 allele in African American\/Black adults. ABCA7 is a transmembrane protein involved in lipid homeostasis and phagocytosis. ABCA7 dysfunction is associated with increased amyloid-beta production, reduced amyloid-beta clearance, impaired microglial response to inflammation, and endoplasmic reticulum stress. This review explores the impact of ABCA7 mutations that increase AD risk in African American\/Black adults on ABCA7 structure and function and their contributions to AD pathogenesis. The combination of biochemical\/biophysical and \u2018omics-based studies of these variants needed to elucidate their downstream impact and molecular contributions to AD pathogenesis is highlighted.<\/jats:p>","DOI":"10.3233\/jad-215306","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T11:36:04Z","timestamp":1642160164000},"page":"5-19","source":"Crossref","is-referenced-by-count":27,"title":["ABCA7, a Genetic Risk Factor Associated with Alzheimer\u2019s Disease Risk in African Americans"],"prefix":"10.1177","volume":"86","author":[{"given":"Kaitlyn E.","family":"Stepler","sequence":"first","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taneisha R.","family":"Gillyard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calla B.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyra M.","family":"Avery","sequence":"additional","affiliation":[{"name":"Department of Life and Physical Sciences, Fisk University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamaine S.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, USA"},{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e3 A.S.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, TN, USA"},{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Vanderbilt Memory and Alzheimer\u2019s Center, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Vanderbilt Institute of Chemical Biology, Nashville, TN, USA"},{"name":"Vanderbilt Brain Institute, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215306_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-150451","article-title":"Dysregulation and diagnostic potential of microRNA in Alzheimer\u2019s disease","volume":"49","author":"Pan","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215306_ref2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"2021 Alzheimer\u2019s disease facts and figures","volume":"17","author":"Alzheimer\u2019s Association","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215306_ref3","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1212\/NXG.0000000000000079","article-title":"Alzheimer\u2019s Disease Genetics Consortium","volume":"2","author":"Cukier","year":"2016","journal-title":"Neurol Genet"},{"key":"10.3233\/JAD-215306_ref4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/WAD.0b013e318211c6c9","article-title":"Diversity and disparity in dementia: The impact of ethnoracial differences in Alzheimer disease","volume":"25","author":"Chin","year":"2011","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-215306_ref5","unstructured":"Manly JJ , Mayeux R (2004) Ethnic differences in dementia and Alzheimer\u2019s disease. 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