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Objective: The aim of the present study was to assess the treatment effect of rivaroxaban administration as well as investigate the roles of PAR-1 and PAR-2 in the AD\u200a+\u200aCAA mice model. Methods: In the present study, we compared a traditional oral anticoagulant, warfarin, and a direct oral anticoagulant (DOAC), rivaroxaban, via long-term administration to an AD with cerebral amyloid angiopathy (CAA) mice model. Results: Rivaroxaban treatment attenuated neuroinflammation, blood-brain barrier dysfunction, memory deficits, and amyloid-\u03b2 deposition through PAR-1\/PAR-2 inhibition in the AD\u200a+\u200aCAA mice model compared with warfarin and no-treatment groups. Conclusion: The present study demonstrates that rivaroxaban can attenuate AD progress and can be a potential choice to prevent AD.<\/jats:p>","DOI":"10.3233\/jad-215318","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T11:48:02Z","timestamp":1641556082000},"page":"111-123","source":"Crossref","is-referenced-by-count":13,"title":["Protective Effect of Rivaroxaban Against Amyloid Pathology and Neuroinflammation Through Inhibiting PAR-1 and PAR-2 in Alzheimer\u2019s Disease Mice"],"prefix":"10.1177","volume":"86","author":[{"given":"Zhihong","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical 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