{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:12:47Z","timestamp":1779318767761,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:p>Background: Cerebral microbleeds (CMBs) are small round\/oval lesions seen in MRI-specific sequences. They are divided in deep and lobar according to their location. Lobar CMBs (L-CMBs) are commonly associated with amyloid angiopathy. Although CMBs have been considered clinically silent for a long time, a growing body of evidence has shown that they could play a crucial role in cognitive functioning. Objective: The aim of this systematic review was to estimate the role of L-CMBs in cognitive performance. Methods: We selected, from the Cochrane Library, Embase, PubMed, and ScienceDirect databases, clinical studies, published from January 2000 to January 2020 and focused on the association between L-CMBs and cognitive functions. The inclusion criteria were: 1) participants grouped according to presence or absence of CMBs, 2) extensive neuropsychological examination, 3) CMBs differentiation according to topographical distribution, and 4) MRI-based CMB definition (&lt;\u200a10\u200amm and low signal in T2*\/SWI). The impact of L-CMBs was separately assessed for executive functions, visuospatial skills, language, and memory. Results: Among 963 potentially eligible studies, six fulfilled the inclusion criteria. Four studies reported a greater reduction in executive performances in participants with L-CMB and two studies showed a statistically significant association between visuospatial dysfunction and L-CMBs. No association was found between hippocampal memory or language abilities and L-CMBs. Conclusion: Lobar CMBs are associated with a reduction of processing speed and visuospatial performances, thus suggesting the contribution of vascular amyloid deposition to this cognitive profile. This occurrence enables us to suspect an underlying Alzheimer\u2019s disease pathology even in absence of typical hippocampal memory impairment.<\/jats:p>","DOI":"10.3233\/jad-215323","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T13:28:27Z","timestamp":1644931707000},"page":"1025-1035","source":"Crossref","is-referenced-by-count":6,"title":["Systematic Review on the Role of Lobar Cerebral Microbleeds in Cognition"],"prefix":"10.1177","volume":"86","author":[{"given":"Lorenzo","family":"Cipriano","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Saracino","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute - Institut du Cerveau (ICM), INSERM U1127, CNRS UMR 7225 \u2013 Aramis Project Team, Inria Research Center of Paris \u2013 Reference Center for Rare or Early Dementias, IM2A, Department of Neurology, AP-HP - H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Oliva","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Campana","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Puoti","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Conforti","sequence":"additional","affiliation":[{"name":"Department of Medicine of Precision, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Fulgione","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples \u201cFederico II\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Signoriello","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bonavita","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-6779","authenticated-orcid":false,"given":"Cinzia","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215323_ref1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.nrl.2016.04.016","article-title":"Brain microbleeds: Epidemiology and clinical implications. Microhemorragias cerebrales: Epidemiolog\u00eda e implicaciones cl\u00ednicas","volume":"33","author":"Boyano","year":"2018","journal-title":"Neurologia"},{"key":"10.3233\/JAD-215323_ref2","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1212\/WNL.0b013e3181c34a7d","article-title":"The Microbleed Anatomical Rating Scale (MARS): Reliability of a tool to map brain microbleeds","volume":"73","author":"Gregoire","year":"2009","journal-title":"Neurology"},{"key":"10.3233\/JAD-215323_ref3","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1212\/WNL.0000000000006780","article-title":"Cerebral microbleeds: Prevalence and relationship to amyloid burden","volume":"92","author":"Graff-Radford","year":"2019","journal-title":"Neurology"},{"key":"10.3233\/JAD-215323_ref4","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","article-title":"Prevalence and risk factors of cerebral microbleeds: The Rotterdam Scan Study","volume":"70","author":"Vernooij","year":"2008","journal-title":"Neurology"},{"key":"10.3233\/JAD-215323_ref5","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.12659\/MSM.891004","article-title":"A meta-analysis of association between cerebral microbleeds and cognitive impairment","volume":"20","author":"Wu","year":"2014","journal-title":"Med Sci Monit"},{"key":"10.3233\/JAD-215323_ref6","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1212\/WNL.0b013e31828b8c16","article-title":"Microbleeds do not affect rate of cognitive decline in Alzheimer disease","volume":"80","author":"Martinez-Ramirez","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-215323_ref7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1212\/WNL.0b013e3182452928","article-title":"Cerebral microbleeds are associated with worse cognitive function: The Rotterdam Scan Study","volume":"78","author":"Poels","year":"2012","journal-title":"Neurology"},{"key":"10.3233\/JAD-215323_ref8","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1161\/STROKEAHA.111.629634","article-title":"Frontal and temporal microbleeds are related to cognitive function: The Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study","volume":"42","author":"van Norden","year":"2011","journal-title":"Stroke"},{"key":"10.3233\/JAD-215323_ref9","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/STROKEAHA.108.531343","article-title":"Progression of mild cognitive impairment to dementia: Contribution of cerebrovascular disease compared with medial temporal lobe atrophy","volume":"40","author":"Staekenborg","year":"2009","journal-title":"Stroke"},{"key":"10.3233\/JAD-215323_ref10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/WAD.0000000000000015","article-title":"Cerebral microbleeds and cognition: The epidemiology of dementia in Singapore study","volume":"28","author":"Hilal","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-215323_ref11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3233\/JAD-2009-1073","article-title":"Serial susceptibility weighted MRI measures brain iron and microbleeds in dementia","volume":"17","author":"Kirsch","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215323_ref12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jmri.22001","article-title":"Imaging cerebral microbleeds using susceptibility weighted imaging: One step toward detecting vascular dementia","volume":"31","author":"Ayaz","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"10.3233\/JAD-215323_ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1055\/s-2006-956752","article-title":"Mild cognitive impairment: Current research and clinical implications","volume":"27","author":"Petersen","year":"2007","journal-title":"Semin Neurol"},{"key":"10.3233\/JAD-215323_ref14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1590\/S1980-57642010DN40100006","article-title":"The Mini Mental State Examination: Review of cutoff points adjusted for schooling in a large Southern Brazilian sample","volume":"4","author":"Kochhann","year":"2010","journal-title":"Dement Neuropsychol"},{"key":"10.3233\/JAD-215323_ref16","doi-asserted-by":"crossref","first-page":"e0147601","DOI":"10.1371\/journal.pone.0147601","article-title":"Panethnic differences in blood pressure in Europe: A systematic review and meta-analysis","volume":"11","author":"Modesti","year":"2016","journal-title":"PLoS One"},{"key":"10.3233\/JAD-215323_ref17","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamaneurol.2016.1017","article-title":"Association of cerebral microbleeds with cognitive decline and dementia","volume":"73","author":"Akoudad","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-215323_ref18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jns.2016.07.018","article-title":"Cerebral microbleeds in patients with mild cognitive impairment and small vessel disease: The Vascular Mild Cognitive Impairment (VMCI)-Tuscany study","volume":"368","author":"Valenti","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-215323_ref19","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s11682-018-9883-3","article-title":"The relationship of cerebral microbleeds to cognition and incident dementia in non-demented older individuals","volume":"13","author":"Paradise","year":"2019","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JAD-215323_ref20","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1212\/WNL.0000000000003983","article-title":"Space and location of cerebral microbleeds, cognitive decline, and dementia in the community","volume":"88","author":"Ding","year":"2017","journal-title":"Neurology"},{"key":"10.3233\/JAD-215323_ref21","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/STROKEAHA.116.014166","article-title":"Strictly lobar cerebral microbleeds are associated with cognitive impairment","volume":"47","author":"Chung","year":"2016","journal-title":"Stroke"},{"key":"10.3233\/JAD-215323_ref22","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/STROKEAHA.111.647065","article-title":"Distributional impact of brain microbleeds on global cognitive function in adults without neurological disorder","volume":"43","author":"Yakushiji","year":"2012","journal-title":"Stroke"},{"key":"10.3233\/JAD-215323_ref23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.11.007","article-title":"Clinical correlating factors and cognitive function in community-dwelling healthy subjects with cerebral microbleeds","volume":"20","author":"Takashima","year":"2011","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.3233\/JAD-215323_ref24","doi-asserted-by":"crossref","first-page":"e008453","DOI":"10.1161\/JAHA.117.008453","article-title":"Cerebral microbleeds are associated with mild cognitive impairment in patients with hypertension","volume":"7","author":"Zhang","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.3233\/JAD-215323_ref25","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1212\/WNL.0000000000000285","article-title":"Incidence of cerebral microbleeds in preclinical Alzheimer disease","volume":"82","author":"Yates","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-215323_ref26","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/01.STR.14.6.924","article-title":"Cerebral amyloid angiopathy: Incidence and complications in the aging brain. II. The distribution of amyloid vascular changes","volume":"14","author":"Vinters","year":"1983","journal-title":"Stroke"},{"key":"10.3233\/JAD-215323_ref27","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ana.22099","article-title":"Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy","volume":"68","author":"Dierksen","year":"2010","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-215323_ref28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abbi.1993.1112","article-title":"Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer\u2019s disease","volume":"301","author":"Miller","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"10.3233\/JAD-215323_ref29","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1074\/jbc.270.13.7013","article-title":"Amyloid beta protein (A beta) in Alzheimer\u2019s disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)","volume":"270","author":"Gravina","year":"1995","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-215323_ref30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s40478-017-0477-x","article-title":"Distinct deposition of amyloid-\u03b2 species in brains with Alzheimer\u2019s disease pathology visualized with MALDI imaging mass spectrometry","volume":"5","author":"Kakuda","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"10.3233\/JAD-215323_ref31","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1073\/pnas.90.22.10836","article-title":"beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer disease","volume":"90","author":"Roher","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-215323_ref32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00401-004-0822-6","article-title":"Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology [published correction appears in Acta Neuropathol (Berl). 2004 May;107(5):479-80]","volume":"107","author":"Attems","year":"2004","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-215323_ref33","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/bi00069a001","article-title":"The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer\u2019s disease","volume":"32","author":"Jarrett","year":"1993","journal-title":"Biochemistry"},{"key":"10.3233\/JAD-215323_ref34","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00702-008-0030-y","article-title":"Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson\u2019s disease, PSP and MSA","volume":"115","author":"Bartels","year":"2008","journal-title":"J Neural Transm (Vienna)"},{"key":"10.3233\/JAD-215323_ref35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.14336\/AD.2017.0112","article-title":"Cerebral microvascular accumulation of tau oligomers in Alzheimer\u2019s disease and related tauopathies","volume":"8","author":"Castillo-Carranza","year":"2017","journal-title":"Aging Dis"},{"key":"10.3233\/JAD-215323_ref36","doi-asserted-by":"crossref","first-page":"E1289","DOI":"10.1073\/pnas.1710329115","article-title":"Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer\u2019s disease","volume":"115","author":"Bennett","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-215323_ref37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00401-016-1560-2","article-title":"Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer\u2019s disease-related microvascular cerebral amyloid angiopathy","volume":"131","author":"Merlini","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-215323_ref38","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/jamaneurol.2015.1359","article-title":"Incidental cerebral microbleeds and cerebral blood flow in elderly individuals","volume":"72","author":"Gregg","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-215323_ref39","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3233\/JAD-150274","article-title":"Cerebral amyloid angiopathy-related microbleeds correlate with glucose metabolism and brain volume in Alzheimer\u2019s disease","volume":"48","author":"Samuraki","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215323_ref40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/cercor\/bhn113","article-title":"The cortical signature of Alzheimer\u2019s disease: Regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals","volume":"19","author":"Dickerson","year":"2009","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-215323_ref41","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/brain\/aws142","article-title":"The differing roles of the frontal cortex in fluency tests","volume":"135(Pt 7)","author":"Robinson","year":"2012","journal-title":"Brain"},{"key":"10.3233\/JAD-215323_ref42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/brain\/awu316","article-title":"Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy","volume":"138(Pt 1)","author":"Reijmer","year":"2015","journal-title":"Brain"},{"key":"10.3233\/JAD-215323_ref43","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1097\/00002093-199912003-00017","article-title":"Overlap between pathology of Alzheimer disease and vascular dementia","volume":"13 Suppl 3","author":"Kalaria","year":"1999","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-215323_ref44","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s007020200068","article-title":"Alzheimer disease and cerebrovascular pathology: An update","volume":"109","author":"Jellinger","year":"2002","journal-title":"J Neural Transm (Vienna)"},{"key":"10.3233\/JAD-215323_ref45","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.neurobiolaging.2015.06.028","article-title":"Cerebral amyloid angiopathy and its co-occurrence with Alzheimer\u2019s disease and other cerebrovascular neuropathologic changes","volume":"36","author":"Brenowitz","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-215323_ref46","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/23279095.2018.1439830","article-title":"Executive, language, or both? An examination of the construct validity of verbal fluency measures","volume":"26","author":"Aita","year":"2019","journal-title":"Appl Neuropsychol Adult"},{"key":"10.3233\/JAD-215323_ref47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.schres.2006.07.024","article-title":"Correlations of functional capacity and neuropsychological performance in older patients with schizophrenia: Evidence for specificity of relationships?","volume":"89","author":"McClure","year":"2007","journal-title":"Schizophr Res"},{"key":"10.3233\/JAD-215323_ref48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.schres.2003.09.007","article-title":"What is measured by verbal fluency tests in schizophrenia?","volume":"69","author":"van Beilen","year":"2004","journal-title":"Schizophr Res"},{"key":"10.3233\/JAD-215323_ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13546800344000309","article-title":"A meta-analytic review of verbal fluency deficits in schizophrenia relative to other neurocognitive deficits","volume":"10","author":"Henry","year":"2005","journal-title":"Cogn Neuropsychiatry"},{"key":"10.3233\/JAD-215323_ref50","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/hbm.21226","article-title":"Different structural correlates for verbal memory impairment in temporal lobe epilepsy with and without mesial temporal lobe sclerosis","volume":"33","author":"Mueller","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-215323_ref51","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1080\/13854046.2012.704073","article-title":"Using the Rey Auditory Verbal Learning Test (RAVLT) to differentiate Alzheimer\u2019s dementia and behavioural variant fronto-temporal dementia","volume":"26","author":"Ricci","year":"2012","journal-title":"Clin Neuropsychol"},{"key":"10.3233\/JAD-215323_ref52","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1162\/jocn_a_00066","article-title":"Working memory and the hippocampus","volume":"23","author":"Baddeley","year":"2011","journal-title":"J Cogn Neurosci"},{"key":"10.3233\/JAD-215323_ref53","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/13803390590935390","article-title":"Processing speed: A strong predictor of verbal memory performance in schizophrenia","volume":"28","author":"Br\u00e9bion","year":"2006","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.3233\/JAD-215323_ref54","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1037\/0894-4105.17.4.539","article-title":"Long-term memory deficits in schizophrenia: Primary or secondary dysfunction?","volume":"17","author":"Holthausen","year":"2003","journal-title":"Neuropsychology"},{"key":"10.3233\/JAD-215323_ref55","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer\u2019s disease based on multifactorial data-driven analysis","volume":"7","author":"Iturria-Medina","year":"2016","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-215323_ref56","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ana.25399","article-title":"Vascular risk and \u03b2-amyloid are synergistically associated with cortical tau","volume":"85","author":"Rabin","year":"2019","journal-title":"Ann Neurol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-215323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:20Z","timestamp":1777370720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-215323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":55,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-215323","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]}}}