{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:09:37Z","timestamp":1789578577939,"version":"build-2803163510"},"reference-count":73,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Understanding how the age of dementia symptom onset affects the longitudinal course of dementia can assist with prognosis and care planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To synthesize evidence regarding the relationship of age of symptom onset with the longitudinal course of sporadic Alzheimer\u2019s disease (AD), vascular dementia (VaD), and frontotemporal dementia (FTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched Medline, CINAHL, Embase, PsycINFO, PubMed, and Scopus for longitudinal studies that examined the impact of sporadic AD, VaD, or FTD symptom onset age on measures of cognition, function, or behavioral symptoms. Studies that examined age at diagnosis only were excluded. Quantitative meta-analysis was conducted where studies reported sufficient data for pooling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty studies met all inclusion criteria (people with AD ( n\u200a=\u200a26), FTD ( n\u200a=\u200a4)) though no studies examined VaD. Earlier onset of AD was associated with more rapid annual cognitive decline (estimate\u200a=\u200a\u20130.07; 95% CI \u20130.14 to 0.00; p\u200a=\u200a0.045). Most studies that stratified their sample reported that younger AD onset (usually\u200a&lt;\u200a65 years) was associated with more rapid cognitive decline. Other evidence was inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Younger people with AD appear to have a poorer prognosis in terms of faster cognitive decline than older people with AD. More research is required to determine the impact of symptom onset age in VaD and FTD, and on functional decline in all dementias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-215360","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T10:30:54Z","timestamp":1640341854000},"page":"1819-1833","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Age of Symptom Onset and Longitudinal Course of Sporadic Alzheimer\u2019s Disease, Frontotemporal Dementia, and Vascular Dementia: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"85","author":[{"given":"Sally","family":"Day","sequence":"first","affiliation":[{"name":"College of Education, Psychology and Social Work, Flinders University, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"National Ageing Research Institute, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie H.","family":"Launder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita M.Y.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"National Ageing Research Institute, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Draper","sequence":"additional","affiliation":[{"name":"School of Psychiatry, UNSW Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Bahar-Fuchs","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Loi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"Neuropsychiatry, Royal Melbourne Hospital, Parkville VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Laver","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Withall","sequence":"additional","affiliation":[{"name":"School of Population Health, UNSW Sydney, NSW, Australia"},{"name":"Ageing Futures Institute, UNSW Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Cations","sequence":"additional","affiliation":[{"name":"College of Education, Psychology and Social Work, Flinders University, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"ref001","unstructured":"PrinceM, WimoA, GuerchetM, AliG-C, WuY-T, PrinaM (2015) World Alzheimer Report 2015. 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