{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:23:52Z","timestamp":1790965432760,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:p>The brainstem is among the first regions to accumulate Alzheimer\u2019s disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-\u03b2 or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.<\/jats:p>","DOI":"10.3233\/jad-215372","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T13:23:23Z","timestamp":1645536203000},"page":"1603-1609","source":"Crossref","is-referenced-by-count":12,"title":["Associations Between Brainstem Volume and Alzheimer\u2019s Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study"],"prefix":"10.1177","volume":"86","author":[{"given":"Heidi I.L.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, Netherlands"},{"name":"Gordon Center for Medical Imaging, Boston, MA, 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