{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:01:50Z","timestamp":1778814110401,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T00:00:00Z","timestamp":1640390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cerebral white matter lesions (WML) are related to a higher risk of vascular and Alzheimer\u2019s dementia. Moreover, oligomerized amyloid-\u03b2 (OA\u03b2) can be measured from blood for dementia screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate the relationship of plasma OA\u03b2 levels with clinical and radiological variables in a health screening population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>WML, other volumetric parameters of magnetic resonance images, cognitive assessment, and plasma OA\u03b2 level were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ninety-two participants were analyzed. The majority of participants\u2019 clinical dementia rating was 0 or 0.5 (96.7%). White matter hyperintensities (WMH) increased with age, but OA\u03b2 levels did not (r\n                      <jats:sup>2<\/jats:sup>\n                      \u200a=\u200a0.19, p\u200a&lt;\u200a0.001, r\n                      <jats:sup>2<\/jats:sup>\n                      \u200a=\u200a0.03, p\u200a=\u200a0.10, respectively). No volumetric data, including cortical thickness\/hippocampal volume, showed any significant correlation with OA\u03b2. Log-WMH volume was positively correlated with OA\u03b2 ( r\u200a=\u200a0.24, p\u200a=\u200a0.02), and this association was significant in the periventricular area. White matter signal abnormalities from 3D-T1 images were also correlated with the OA\u03b2 in the periventricular area ( p\u200a=\u200a0.039). Multivariate linear regression showed that log-WMH values were independently associated with OA\u03b2 ( B\u200a=\u200a0.879 (95% confidence interval 0.098 \u20131.660, p\u200a=\u200a0.028)). Higher tertiles of WMH showed higher OA\u03b2 levels than lower tertiles showed ( p\u200a=\u200a0.044). Using a cutoff of 0.78 ng\/mL, the high OA\u03b2 group had a larger WMH volume, especially in the periventricular area, than the low OA\u03b2 group ( p\u200a=\u200a0.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both WML and plasma OA\u03b2 levels can be early markers for neurodegeneration in the healthcare population. The lesions, especially in the periventricular area, might be related to amyloid pathogenesis, which strengthens the importance of WML in the predementia stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-215399","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T12:36:10Z","timestamp":1640694970000},"page":"1835-1844","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of Plasma Oligomerized Amyloid-\u03b2 and Cerebral White Matter Lesions in a Health Screening Population"],"prefix":"10.1177","volume":"85","author":[{"given":"Keun-Hwa","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul, South Korea"},{"name":"Department of Neurology, College of Medicine, Seoul National University, Seoul, South 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Korea"},{"name":"Department of Neurology, College of Medicine, Seoul National University, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Kun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul, South Korea"},{"name":"Department of Neurology, College of Medicine, Seoul National University, Seoul, South 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