{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:47:58Z","timestamp":1791607678218,"version":"4.3.4"},"reference-count":74,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,3,8]]},"abstract":"<jats:p>Background: In mouse models of amyloidosis, macrophage receptor 1 (MSR1) and neprilysin (NEP) have been shown to interact to reduce amyloid burden in the brain. Objective: The purpose of this study is to analyze these two gene products in combination with apolipoproteins and A\u03b21-42 in the cerebrospinal fluid (CSF) and plasma of individuals at different stages of Alzheimer\u2019s disease (AD), as well as in autopsied brain samples from ROSMAP (Religious Orders Study and Memory and Aging Project). Methods: CSF\/plasma levels of MSR1 and NEP were measured using the sensitive primer extension assay technology. CSF A\u03b21-42 was assessed with ELISA, while CSF ApoE and ApoJ were measured with the Luminex\u2019s multiplex technology. Brain MSR1, APOE, and CLU (APOJ) mRNA levels were measured with RNA-Seq and contrasted to amyloid plaques pathology using CERAD staging. Results: While plasma and CSF MSR1 levels are significantly correlated, this correlation was not observed for NEP. In addition to be highly correlated to one another, CSF levels of both MSR1 and NEP are strongly correlated with AD status and CSF A\u03b21-42, ApoE, and ApoJ levels. In the cortical tissues of subjects from ROSMAP, MSR1 mRNA levels are correlated with CLU mRNA levels and the CERAD scores but not with APOE mRNA levels. Conclusion: The discrepancies observed between CSF\/plasma levels of MSR1 and NEP with CSF A\u03b21-42 and ApoE concentrations can be explained by many factors, such as the disease stage or the involvement of the blood-brain barrier breakdown that leads to the infiltration of peripheral monocytes or macrophages.<\/jats:p>","DOI":"10.3233\/jad-215410","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T11:47:56Z","timestamp":1642160876000},"page":"283-296","source":"Crossref","is-referenced-by-count":13,"title":["MSR1 and NEP Are Correlated with Alzheimer\u2019s Disease Amyloid Pathology and Apolipoprotein Alterations"],"prefix":"10.1177","volume":"86","author":[{"given":"Justin","family":"Miron","sequence":"first","affiliation":[{"name":"Douglas Hospital Research Centre, Montr\u00e9al, QC, Canada"},{"name":"Centre for the Studies on the Prevention of Alzheimer\u2019s Disease, Montr\u00e9al, QC, Canada"},{"name":"McGill University, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PREVENT-AD research group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Picard","sequence":"additional","affiliation":[{"name":"Douglas Hospital Research Centre, Montr\u00e9al, QC, Canada"},{"name":"Centre for the Studies on the Prevention of Alzheimer\u2019s Disease, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Labont\u00e9","sequence":"additional","affiliation":[{"name":"Douglas Hospital Research Centre, Montr\u00e9al, QC, Canada"},{"name":"Centre for the Studies on the Prevention of Alzheimer\u2019s Disease, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Auld","sequence":"additional","affiliation":[{"name":"McGill University, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[{"name":"Douglas Hospital Research Centre, Montr\u00e9al, QC, Canada"},{"name":"Centre for the Studies on the Prevention of Alzheimer\u2019s Disease, Montr\u00e9al, QC, Canada"},{"name":"McGill University, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215410_ref1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0006-291X(84)91209-9","article-title":"Alzheimer\u2019s disease and Down\u2019s syndrome: Sharing of a unique cerebrovascular amyloid fibril protein","volume":"122","author":"Glenner","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-215410_ref2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00692056","article-title":"Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. 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