{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:49Z","timestamp":1787025889333,"version":"build-2736575974"},"reference-count":65,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,6,14]]},"abstract":"<jats:p>Background: The association between sleep and Alzheimer\u2019s disease (AD) biomarkers are well-established, but little is known about how they interact to change the course of AD. Objective: To determine the potential interaction between sleep disturbance and A\u03b2, tau, and APOE4 on brain atrophy and cognitive decline. Methods: Sample included 351 participants (mean age 72.01 \u00b1 6.67, 50.4%female) who were followed for approximately 5 years as part of the Alzheimer\u2019s Disease Neuroimaging Initiative. Informant-reported sleep disturbance (IRSD) was measured using the Neuropsychiatric Inventory (NPI). Changes in magnetic resonance imaging (MRI)-measured AD signature brain regions and cognitive performance and IRSD\u2019s interaction with cerebrospinal fluid amyloid-\u03b2 (A\u03b242) and p-Tau depositions and APOE4 status were examined using the linear mixed models. Results: Baseline IRSD was not significantly associated with the rate of atrophy after adjusting for covariates (age, sex, education, total NPI severity score, and sleep medications). However, there was a significant interaction between IRSD and AD biomarkers on faster atrophy rates in multiple brain regions, including the cortical and middle temporal volumes. Post-hoc analyses indicated that A\u03b2 and p-Tau\/A\u03b2 predicted a faster decline in these regions\/domains in IRSD, compared with biomarker-negative individuals with IRSD (ps\u22640.001). There was a significant IRSD*APOE4 interaction for brain atrophy rate (ps\u22640.02) but not for cognition. Conclusion: IRSD may increase the future risk of AD by contributing to faster brain atrophy and cognitive decline when combined with the presence of AD biomarkers and APOE4. Early intervention for sleep disturbance could help reduce the risk of developing AD.<\/jats:p>","DOI":"10.3233\/jad-215417","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T12:19:02Z","timestamp":1651234742000},"page":"1567-1580","source":"Crossref","is-referenced-by-count":12,"title":["The Role of Amyloid, Tau, and APOE Genotype on the Relationship Between Informant-Reported Sleep Disturbance and Alzheimer\u2019s Disease Risks"],"prefix":"10.1177","volume":"87","author":[{"given":"Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA"},{"name":"Division of Geriatric Psychiatry, New York State Psychiatric Institute, NewYork, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Levine","sequence":"additional","affiliation":[{"name":"Division of Mental Health Data Science, New York State Psychiatric Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Geriatric Psychiatry, New York State Psychiatric Institute, NewYork, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Gehrman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Mental Illness Research, Education, and Clinical Center, Corporal Michael J. 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