{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:16:00Z","timestamp":1778919360313,"version":"3.51.4"},"reference-count":296,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:p>Background: A complex network of aging-related homeostatic pathways that are sensitive to further deterioration in the presence of genetic, systemic, and environmental risk factors, and lifestyle, is implicated in the pathogenesis of progressive neurodegenerative diseases, such as sporadic (late-onset) Alzheimer\u2019s disease (sAD). Objective: Since sAD pathology and neurotoxicity share microRNAs (miRs) regulating common as well as overlapping pathological processes, environmental neurotoxic compounds are hypothesized to exert a risk for sAD initiation and progression. Methods: Literature search for miRs associated with human sAD and environmental neurotoxic compounds was conducted. Functional miR analysis using PathDip was performed to create miR-target interaction networks. Results: The identified miRs were successfully linked to the hypothetical starting point and key events of the earlier proposed tau-driven adverse outcome pathway toward memory loss. Functional miR analysis confirmed most of the findings retrieved from literature and revealed some interesting findings. The analysis identified 40 miRs involved in both sAD and neurotoxicity that dysregulated processes governing the plausible adverse outcome pathway for memory loss. Conclusion: Creating miR-target interaction networks related to pathological processes involved in sAD initiation and progression, and environmental chemical-induced neurotoxicity, respectively, provided overlapping miR-target interaction networks. This overlap offered an opportunity to create an alternative picture of the mechanisms underlying sAD initiation and early progression. Looking at initiation and progression of sAD from this new angle may open for new biomarkers and novel drug targets for sAD before the appearance of the first clinical symptoms.<\/jats:p>","DOI":"10.3233\/jad-215434","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T13:23:52Z","timestamp":1645536232000},"page":"1427-1457","source":"Crossref","is-referenced-by-count":6,"title":["Sporadic Alzheimer\u2019s Disease- and Neurotoxicity-Related microRNAs Affecting Key Events of Tau-Driven Adverse Outcome Pathway Toward Memory Loss"],"prefix":"10.1177","volume":"86","author":[{"given":"Maria","family":"Tsamou","sequence":"first","affiliation":[{"name":"ToxGenSolutions (TGS), Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Carpi","sequence":"additional","affiliation":[{"name":"European Commission, Joint Research Centre (JRC), Ispra VA, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pistollato","sequence":"additional","affiliation":[{"name":"European Commission, Joint Research Centre (JRC), Ispra VA, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin L.","family":"Roggen","sequence":"additional","affiliation":[{"name":"ToxGenSolutions (TGS), Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215434_ref2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3934\/Neuroscience.2021005","article-title":"The biological pathways of Alzheimer disease: A review","volume":"8","author":"Calabr\u00f2","year":"2020","journal-title":"AIMS Neurosci"},{"key":"10.3233\/JAD-215434_ref3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1741-7015-10-127","article-title":"Preclinical Alzheimer disease: Identification of cases at risk among cognitively intact older individuals","volume":"10","author":"Lazarczyk","year":"2012","journal-title":"BMC Med"},{"key":"10.3233\/JAD-215434_ref4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215434_ref5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2019.03.005","article-title":"Gene-environment interactions in Alzheimer\u2019s disease: A potential path to precision medicine","volume":"199","author":"Eid","year":"2019","journal-title":"Pharmacol Ther"},{"key":"10.3233\/JAD-215434_ref6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neubiorev.2019.06.018","article-title":"Gene-by-environment interactions in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"103","author":"Dunn","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-215434_ref7","doi-asserted-by":"crossref","unstructured":"Bartolotti N , Lazarov O (2016) Lifestyle and Alzheimer\u2019s disease: The role of environmental factors in disease development. In Genes, environment and Alzheimer\u2019s disease. Elsevier Academic Press, San Diego, CA, US, pp. 197\u2013237.","DOI":"10.1016\/B978-0-12-802851-3.00007-3"},{"key":"10.3233\/JAD-215434_ref8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3389\/fnins.2019.00659","article-title":"Alzheimer disease pathogenesis: Insights from molecular and cellular biology studies of oligomeric A\u03b2 and tau species","volume":"13","author":"Chen","year":"2019","journal-title":"Front Neurosci"},{"key":"10.3233\/JAD-215434_ref9","doi-asserted-by":"crossref","first-page":"926","DOI":"10.2174\/1570159X15666170116143743","article-title":"The amyloid cascade hypothesis in Alzheimer\u2019s disease: It\u2019s time to change our mind","volume":"15","author":"Ricciarelli","year":"2017","journal-title":"Curr Neuropharmacol"},{"key":"10.3233\/JAD-215434_ref10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tips.2017.03.011","article-title":"A brief overview of tauopathy: Causes, consequences, and therapeutic strategies","volume":"38","author":"Orr","year":"2017","journal-title":"Trends Pharmacol Sci"},{"key":"10.3233\/JAD-215434_ref11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-201418","article-title":"A tau-driven adverse outcome pathway blueprint toward memory loss in sporadic (late-onset) Alzheimer\u2019s disease with plausible molecular initiating event plug-ins for environmental neurotoxicants","volume":"81","author":"Tsamou","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref12","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3390\/ijerph7041540","article-title":"Ethanol and cognition: Indirect effects, neurotoxicity and neuroprotection: A review","volume":"7","author":"Brust","year":"2010","journal-title":"Int J Environ Res Public Health"},{"key":"10.3233\/JAD-215434_ref13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0006-8993(03)02885-3","article-title":"Nicotine is a neurotoxin in the adolescent brain: Critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations","volume":"979","author":"Abreu-Villa\u00e7a","year":"2003","journal-title":"Brain Res"},{"key":"10.3233\/JAD-215434_ref14","doi-asserted-by":"crossref","unstructured":"Mohammad Ahmadi Soleimani S , Ekhtiari H , Cadet JL (2016) Chapter 2 - Drug-induced neurotoxicity in addiction medicine: From prevention to harm reduction. In Progress in Brain Research, Ekhtiari H, Paulus M, eds. Elsevier, pp. 19\u201341.","DOI":"10.1016\/bs.pbr.2015.07.004"},{"key":"10.3233\/JAD-215434_ref15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/B978-0-444-62627-1.00011-1","article-title":"Neurotoxicity of metals","volume":"131","author":"Caito","year":"2015","journal-title":"Handb Clin Neurol"},{"key":"10.3233\/JAD-215434_ref16","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/S0140-6736(00)02685-4","article-title":"Pesticide exposure and risk of mild cognitive dysfunction","volume":"356","author":"Bosma","year":"2000","journal-title":"Lancet"},{"key":"10.3233\/JAD-215434_ref17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tox.2013.02.002","article-title":"Linking pesticide exposure and dementia: What is the evidence?","volume":"307","author":"Zaganas","year":"2013","journal-title":"Toxicology"},{"key":"10.3233\/JAD-215434_ref18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bj.2018.06.001","article-title":"The emerging risk of exposure to air pollution on cognitive decline and Alzheimer\u2019s disease - Evidence from epidemiological and animal studies","volume":"41","author":"Kilian","year":"2018","journal-title":"Biomed J"},{"key":"10.3233\/JAD-215434_ref19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cotox.2017.10.008","article-title":"Oxidative stress from environmental exposures","volume":"7","author":"Samet","year":"2018","journal-title":"Curr Opin Toxicol"},{"key":"10.3233\/JAD-215434_ref20","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.2741\/2758","article-title":"Neurotoxicity of pesticides: A brief review","volume":"13","author":"Costa","year":"2008","journal-title":"Front Biosci"},{"key":"10.3233\/JAD-215434_ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kft102","article-title":"Mitochondria as a target of environmental toxicants","volume":"134","author":"Meyer","year":"2013","journal-title":"Toxicol Sci"},{"key":"10.3233\/JAD-215434_ref22","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.envpol.2017.12.102","article-title":"Role of autophagy in environmental neurotoxicity","volume":"235","author":"Pellacani","year":"2018","journal-title":"Environ Pollut"},{"key":"10.3233\/JAD-215434_ref23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tins.2009.05.009","article-title":"Air pollution: Mechanisms of neuroinflammation and CNS disease","volume":"32","author":"Block","year":"2009","journal-title":"Trends Neurosci"},{"key":"10.3233\/JAD-215434_ref24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/109374099281205","article-title":"Organophosphorus pesticides: Do they all have the same mechanism of toxicity?","volume":"2","author":"Pope","year":"1999","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"10.3233\/JAD-215434_ref25","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.fct.2010.03.013","article-title":"Malathion exposure modulates hypothalamic gene expression and induces dyslipedemia in Wistar rats","volume":"48","author":"Rezg","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.3233\/JAD-215434_ref26","doi-asserted-by":"crossref","first-page":"e5186","DOI":"10.1371\/journal.pone.0005186","article-title":"Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance","volume":"4","author":"Lim","year":"2009","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref27","doi-asserted-by":"crossref","first-page":"17014","DOI":"10.1289\/EHP5053","article-title":"Screening ToxCast\u2122 for chemicals that affect cholesterolbiosynthesis: Studies in cell culture and human induced pluripotentstem cell-derived neuroprogenitors","volume":"128","author":"Wages","year":"2020","journal-title":"Environ Health Perspect"},{"key":"10.3233\/JAD-215434_ref28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3233\/JAD-2012-111946","article-title":"Pesticides induce spatial memory deficits with synapticimpairments and an imbalanced tau phosphorylation in rats","volume":"30","author":"Chen","year":"2012","journal-title":"JAlzheimers Dis"},{"key":"10.3233\/JAD-215434_ref29","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA sequences to function","volume":"47","author":"Kozomara","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.3233\/JAD-215434_ref30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cca.2018.05.039","article-title":"Circulating microRNAs as novel biomarkers of Alzheimer\u2019s disease","volume":"484","author":"Zendjabil","year":"2018","journal-title":"Clin Chim Acta"},{"key":"10.3233\/JAD-215434_ref31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnins.2012.00059","article-title":"Crosstalk among epigenetic pathways regulates neurogenesis","volume":"6","author":"Jobe","year":"2012","journal-title":"Front Neurosci"},{"key":"10.3233\/JAD-215434_ref32","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.clinbiochem.2013.03.015","article-title":"Circulating miRNAs as sensitive andspecific biomarkers for the diagnosis and monitoring of humandiseases: Promises and challenges","volume":"46","author":"De Guire","year":"2013","journal-title":"Clin Biochem"},{"key":"10.3233\/JAD-215434_ref33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3390\/cells10010113","article-title":"microRNAs as early biomarkers ofAlzheimer\u2019s disease: A synaptic perspective","volume":"10","author":"Siedlecki-Wullich","year":"2021","journal-title":"Cells"},{"key":"10.3233\/JAD-215434_ref34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2217\/fnl.10.58","article-title":"Biogenesis and regulation of microRNA: Implication in Alzheimer\u2019s disease","volume":"5","author":"Mouton-Liger","year":"2010","journal-title":"Future Neurol"},{"key":"10.3233\/JAD-215434_ref35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1515\/revneuro-2017-0042","article-title":"microRNA in Alzheimer\u2019s disease revisited: Implications for major neuropathological mechanisms","volume":"29","author":"Dehghani","year":"2017","journal-title":"Rev Neurosci"},{"key":"10.3233\/JAD-215434_ref36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1515\/bmc-2016-0014","article-title":"Alzheimer\u2019s disease: Presence and role of microRNAs","volume":"7","author":"Basavaraju","year":"2016","journal-title":"Biomol Concepts"},{"key":"10.3233\/JAD-215434_ref37","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2174\/1567205014666170829101016","article-title":"miRNAs in Alzheimer disease \u2013a therapeutic perspectives","volume":"14","author":"Gupta","year":"2017","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-215434_ref38","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3390\/genes9040174","article-title":"The role of microRNAs in Alzheimer\u2019s disease and their therapeutic potentials","volume":"9","author":"Miya Shaik","year":"2018","journal-title":"Genes"},{"key":"10.3233\/JAD-215434_ref39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1573406411666151030112140","article-title":"miRNAs as circulating biomarkers for Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"12","author":"Mushtaq","year":"2016","journal-title":"Med Chem"},{"key":"10.3233\/JAD-215434_ref40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fnagi.2017.00323","article-title":"miRNA in circulating microvesicles as biomarkers for age-related cognitive decline","volume":"9","author":"Rani","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-215434_ref41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13195-017-0316-0","article-title":"Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases","volume":"9","author":"Sheinerman","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-215434_ref42","doi-asserted-by":"crossref","first-page":"870150","DOI":"10.1155\/2012\/870150","article-title":"microRNAs in neurotoxicity","volume":"2012","author":"Kaur","year":"2012","journal-title":"J Toxicol"},{"key":"10.3233\/JAD-215434_ref43","doi-asserted-by":"crossref","first-page":"D78","DOI":"10.1093\/nar\/gkt1266","article-title":"miRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions","volume":"42","author":"Hsu","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.3233\/JAD-215434_ref44","first-page":"D479","article-title":"pathDIP 4: An extended pathway annotations and enrichment analysis resource for human, model organisms and domesticated species","volume":"48","author":"Rahmati","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.3233\/JAD-215434_ref45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.envint.2019.04.063","article-title":"Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks","volume":"128","author":"Krauskopf","year":"2019","journal-title":"Environ Int"},{"key":"10.3233\/JAD-215434_ref46","doi-asserted-by":"crossref","first-page":"017007","DOI":"10.1289\/EHP1447","article-title":"Fine particulate air pollution and the expression of microRNAs and circulating cytokines relevant to inflammation, coagulation, and vasoconstriction","volume":"126","author":"Chen","year":"2018","journal-title":"Environ Health Perspect"},{"key":"10.3233\/JAD-215434_ref47","doi-asserted-by":"crossref","first-page":"18422","DOI":"10.3390\/ijms151018422","article-title":"Characterization of paraquat-induced miRNA profiling response in hNPCs undergoing proliferation","volume":"15","author":"Huang","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-215434_ref48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/WNR.0b013e3280148e8b","article-title":"Micro-RNA speciation in fetal, adult and Alzheimer\u2019s disease hippocampus","volume":"18","author":"Lukiw","year":"2007","journal-title":"Neuroreport"},{"key":"10.3233\/JAD-215434_ref49","doi-asserted-by":"crossref","first-page":"30105","DOI":"10.3390\/ijms161226223","article-title":"microRNA (miRNA) signaling in the human CNS in sporadic Alzheimer\u2019s disease (AD)-novel and unique pathological features","volume":"16","author":"Zhao","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-215434_ref50","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.jinorgbio.2009.05.012","article-title":"Characterization of an NF-\u03baB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells","volume":"103","author":"Pogue","year":"2009","journal-title":"J Inorg Biochem"},{"key":"10.3233\/JAD-215434_ref51","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.3892\/mmr.2017.6809","article-title":"microRNA-322 attenuates aluminum maltolate-induced apoptosis in the human SH-SY5Y neuroblastoma cell line","volume":"16","author":"Ma","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.3233\/JAD-215434_ref52","doi-asserted-by":"crossref","first-page":"108181","DOI":"10.1016\/j.abb.2019.108181","article-title":"Neuroprotection of miR-214 against isoflurane-induced neurotoxicity involves the PTEN\/PI3K\/Akt pathway in human neuroblastoma cell line SH-SY5Y","volume":"678","author":"Wu","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"10.3233\/JAD-215434_ref53","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/WNR.0b013e32833da51a","article-title":"Acyclovir or A\u03b242 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells","volume":"21","author":"Lukiw","year":"2010","journal-title":"Neuroreport"},{"key":"10.3233\/JAD-215434_ref54","first-page":"177","article-title":"Drug development for tauopathy and Alzheimer\u2019s disease","volume":"30","author":"Takashima","year":"2010","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"10.3233\/JAD-215434_ref55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2407-10-27","article-title":"microRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol","volume":"10","author":"Ren","year":"2010","journal-title":"BMC Cancer"},{"key":"10.3233\/JAD-215434_ref56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12974-017-0799-4","article-title":"Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7","volume":"14","author":"Coleman","year":"2017","journal-title":"J Neuroinflammation"},{"key":"10.3233\/JAD-215434_ref57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40139-020-00208-8","article-title":"The regulatory roleof mirnas in ethanol-induced TLR4 activation and neuroinflammation","volume":"8","author":"Pascual","year":"2020","journal-title":"Cur Pathobiol Rep"},{"key":"10.3233\/JAD-215434_ref58","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/humrep\/den439","article-title":"Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation","volume":"24","author":"Wang","year":"2009","journal-title":"Hum Reprod"},{"key":"10.3233\/JAD-215434_ref59","doi-asserted-by":"crossref","first-page":"8546","DOI":"10.1523\/JNEUROSCI.1269-07.2007","article-title":"Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: Evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium","volume":"27","author":"Sathyan","year":"2007","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref60","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1017\/S1461145708009528","article-title":"Nicotine modulates expression of miR-140*, which targets the 3\u2032-untranslated region of dynamin 1 gene (Dnm1)","volume":"12","author":"Huang","year":"2009","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.3233\/JAD-215434_ref61","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1083\/jcb.201103006","article-title":"Targeting of the Arpc3 actin nucleation factor by miR-29a\/b regulates dendritic spine morphology","volume":"194","author":"Lippi","year":"2011","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-215434_ref62","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1523\/JNEUROSCI.5397-12.2013","article-title":"Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation","volume":"33","author":"Abisambra","year":"2013","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref63","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1289\/ehp.11841","article-title":"RDX induces aberrant expression of microRNAs in mouse brain and liver","volume":"117","author":"Zhang","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.3233\/JAD-215434_ref64","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/npp.2008.131","article-title":"Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers","volume":"34","author":"Zhou","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.3233\/JAD-215434_ref65","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1126\/science.1193692","article-title":"MiR-16 targets the serotonin transporter: A new facet for adaptive responses to antidepressants","volume":"329","author":"Baudry","year":"2010","journal-title":"Science"},{"key":"10.3233\/JAD-215434_ref66","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1080\/03601234.2010.502435","article-title":"Effect of triazophos, fipronil and their mixture on miRNA expression in adult zebrafish","volume":"45","author":"Wang","year":"2010","journal-title":"J Environ Sci Health B"},{"key":"10.3233\/JAD-215434_ref67","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.3390\/ijms19123705","article-title":"microRNAs as regulators of insulin signaling: Research updates and potential therapeutic perspectives in type 2 diabetes","volume":"19","author":"Nigi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-215434_ref68","doi-asserted-by":"crossref","first-page":"e00170","DOI":"10.1128\/MCB.00170-19","article-title":"microRNA 7impairs insulin signaling and regulates A\u03b2 levels throughposttranscriptional regulation of the insulin receptor substrate 2,insulin receptor, insulin-degrading enzyme, and liver X receptorpathway","volume":"39","author":"Fern\u00e1ndez-de Frutos","year":"2019","journal-title":"Mol Cell Biol"},{"key":"10.3233\/JAD-215434_ref69","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.neurobiolaging.2013.06.007","article-title":"Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand","volume":"34","author":"Fenn","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-215434_ref70","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fgene.2014.00472","article-title":"Regulation of IGF -1 signaling by microRNAs","volume":"5","author":"Jung","year":"2015","journal-title":"Front Genet"},{"key":"10.3233\/JAD-215434_ref71","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00592-020-01486-9","article-title":"Altered circulatory levels of miR-128, BDNF, cortisol and shortened telomeres in patients with type 2 diabetes and depression","volume":"57","author":"Prabu","year":"2020","journal-title":"Acta Diabetol"},{"key":"10.3233\/JAD-215434_ref72","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1476-4598-13-33","article-title":"Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128","volume":"13","author":"Adlakha","year":"2014","journal-title":"Mol Cancer"},{"key":"10.3233\/JAD-215434_ref73","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3233\/JAD-150741","article-title":"miR-302 attenuates amyloid-\u03b2-induced neurotoxicity through activation of Akt signaling","volume":"50","author":"Li","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref74","doi-asserted-by":"crossref","first-page":"e8344","DOI":"10.1590\/1414-431x20198344","article-title":"Pancreatic \u03b2-cell function isinhibited by miR-3666 in type 2 diabetes mellitus by targetingadiponectin","volume":"52","author":"Tan","year":"2019","journal-title":"Braz J Med Biol Res"},{"key":"10.3233\/JAD-215434_ref75","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neurobiolaging.2013.10.082","article-title":"Epigenetically regulated microRNAs in Alzheimer\u2019s disease","volume":"35","author":"Van den Hove","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-215434_ref76","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer\u2019s disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref77","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jmcb\/mjs049","article-title":"A regulatory circuit of miR-148a\/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1","volume":"5","author":"Xu","year":"2013","journal-title":"J Mol Cell Biol"},{"key":"10.3233\/JAD-215434_ref78","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s12264-013-1348-5","article-title":"MicroRNA-98 induces an Alzheimer\u2019s disease-like disturbance by targeting insulin-like growth factor 1","volume":"29","author":"Hu","year":"2013","journal-title":"Neurosci Bull"},{"key":"10.3233\/JAD-215434_ref79","doi-asserted-by":"crossref","first-page":"e0196929","DOI":"10.1371\/journal.pone.0196929","article-title":"Defensive effect of microRNA-200b\/c against amyloid-beta peptide-induced toxicity in Alzheimer\u2019s disease models","volume":"13","author":"Higaki","year":"2018","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref80","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/db17-0141","article-title":"Altered miR-29 expression in type 2 diabetes influences glucose and lipid metabolism in skeletal muscle","volume":"66","author":"Massart","year":"2017","journal-title":"Diabetes"},{"key":"10.3233\/JAD-215434_ref81","doi-asserted-by":"crossref","first-page":"e17343","DOI":"10.1371\/journal.pone.0017343","article-title":"The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes","volume":"6","author":"Ryu","year":"2011","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref82","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/mol.108.052118","article-title":"Regulation of the mammalian nervous system by microRNAs","volume":"75","author":"Zeng","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.3233\/JAD-215434_ref83","doi-asserted-by":"crossref","first-page":"28387","DOI":"10.1038\/srep28387","article-title":"Genome-wide identification of microRNA-related variants associated with risk of Alzheimer\u2019s disease","volume":"6","author":"Ghanbari","year":"2016","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-215434_ref84","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbrc.2014.11.111","article-title":"ApoE-isoform-dependent cellular uptake of amyloid-\u03b2 is mediated by lipoprotein receptor LR11\/SorLA","volume":"456","author":"Yajima","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-215434_ref85","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1523\/JNEUROSCI.4571-15.2016","article-title":"Understanding the role of miR-33 in brain lipid metabolism: Implications for Alzheimer\u2019s disease","volume":"36","author":"Jaouen","year":"2016","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref86","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fphys.2015.00040","article-title":"The emerging role of microRNAs in Alzheimer\u2019s disease","volume":"6","author":"Femminella","year":"2015","journal-title":"Front Physiol"},{"key":"10.3233\/JAD-215434_ref87","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.bbalip.2016.04.020","article-title":"microRNAs in brain cholesterol metabolism and their implications for Alzheimer\u2019s disease","volume":"1861","author":"Yoon","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-215434_ref88","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuroscience.2018.08.003","article-title":"The age-dependent elevation of miR-335-3p leads to reduced cholesterol and impaired memory in brain","volume":"390","author":"Raihan","year":"2018","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-215434_ref89","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1007\/s12035-016-0088-8","article-title":"PlasmamiR-34a-5p and miR-545-3p as early biomarkers of Alzheimer\u2019sdisease: Potential and limitations","volume":"54","author":"Cos\u00edn-Tom\u00e1s","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-215434_ref90","doi-asserted-by":"crossref","first-page":"e11884","DOI":"10.1371\/journal.pone.0011884","article-title":"Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal A\u03b242 uptake and lysosomal trafficking","volume":"5","author":"Fuentealba","year":"2010","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref91","first-page":"14820","article-title":"microRNA-137\/181c regulates serine palmitoyltransferase and in turn amyloid \u03b2, novel targets in sporadic Alzheimer\u2019s disease","volume":"31","author":"Geekiyanage","year":"2011","journal-title":"J Neurosci Res"},{"key":"10.3233\/JAD-215434_ref92","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/CIRCRESAHA.108.181651","article-title":"miR-1 overexpression enhances Ca2+ release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56a; and causing CaMKII-dependent hyperphosphorylation of RyR2","volume":"104","author":"Terentyev","year":"2009","journal-title":"Circ Res"},{"key":"10.3233\/JAD-215434_ref93","doi-asserted-by":"crossref","first-page":"e00470","DOI":"10.1128\/MCB.00470-19","article-title":"microRNA 27a is a key modulator of cholesterol biosynthesis","volume":"40","author":"Khan","year":"2020","journal-title":"Mol Cell Biol"},{"key":"10.3233\/JAD-215434_ref94","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.atherosclerosis.2015.09.033","article-title":"miR-27b inhibits LDLR and ABCA1 expression but does not influenceplasma and hepatic lipid levels in mice","volume":"243","author":"Goedeke","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.3233\/JAD-215434_ref95","doi-asserted-by":"crossref","first-page":"18397","DOI":"10.1074\/jbc.M116.728451","article-title":"microRNA-30c mimic mitigates hypercholesterolemia and atherosclerosis in mice","volume":"291","author":"Irani","year":"2016","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-215434_ref96","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/nm.3949","article-title":"microRNA-148a regulates LDL receptorand ABCA1 expression to control circulating lipoprotein levels","volume":"21","author":"Goedeke","year":"2015","journal-title":"Nat Med"},{"key":"10.3233\/JAD-215434_ref97","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bbalip.2014.02.006","article-title":"miR-206 controls LXR\u03b1 expression and promotes LXR-mediated cholesterol efflux in macrophages","volume":"1841","author":"Vinod","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-215434_ref98","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbrc.2014.04.052","article-title":"miR-613 regulates cholesterol efflux by targeting LXR\u03b1 and ABCA1 in PPAR\u03b3 activated THP-1 macrophages","volume":"448","author":"Zhao","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-215434_ref99","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/genes5040865","article-title":"The role of microRNAs in mitochondria: Small players acting wide","volume":"5","author":"Duarte","year":"2014","journal-title":"Genes"},{"key":"10.3233\/JAD-215434_ref100","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1074\/jbc.M115.691352","article-title":"microRNA-7 regulates the function of mitochondrial permeability transition pore by targeting VDAC1 expression","volume":"291","author":"Chaudhuri","year":"2016","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-215434_ref101","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1093\/hmg\/ddr210","article-title":"microRNA profiling of Parkinson\u2019s disease brainsidentifies early downregulation of miR-34b\/c which modulatemitochondrial function","volume":"20","author":"Mi\u00f1ones-Moyano","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.3233\/JAD-215434_ref102","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbadis.2014.11.019","article-title":"TNF-\u03b1 regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells","volume":"1852","author":"Prajapati","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-215434_ref103","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/0271678X15606147","article-title":"MiR-34a regulates blood-brain barrier permeability and mitochondrialfunction by targeting cytochrome c","volume":"36","author":"Bukeirat","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.3233\/JAD-215434_ref104","first-page":"275","article-title":"Deficiency of the miR-29a\/b-1 cluster leads toataxic features and cerebellar alterations in mice","volume":"73","author":"Papadopoulou","year":"2015","journal-title":"NeurobiolDis"},{"key":"10.3233\/JAD-215434_ref105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12915-017-0354-x","article-title":"microRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging","volume":"15","author":"Ripa","year":"2017","journal-title":"BMC Biol"},{"key":"10.3233\/JAD-215434_ref106","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41598-017-17878-x","article-title":"High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria","volume":"8","author":"Yardeni","year":"2018","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-215434_ref107","doi-asserted-by":"crossref","first-page":"35205","DOI":"10.1038\/srep35205","article-title":"microRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection","volume":"6","author":"He","year":"2016","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-215434_ref108","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1002\/jcb.26700","article-title":"Protective effects of microRNA-330 on amyloid \u03b2-protein production, oxidative stress, and mitochondrial dysfunction in Alzheimer\u2019s disease by targeting VAV1 via the MAPK signaling pathway","volume":"119","author":"Zhou","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.3233\/JAD-215434_ref109","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/jcb.24004","article-title":"Control of mitochondrial activity by miRNAs","volume":"113","author":"Li","year":"2012","journal-title":"J Cell Biochem"},{"key":"10.3233\/JAD-215434_ref110","doi-asserted-by":"crossref","first-page":"12581","DOI":"10.1523\/JNEUROSCI.3338-08.2008","article-title":"microRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons","volume":"28","author":"Aschrafi","year":"2008","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref111","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbagen.2013.09.002","article-title":"microRNAs as regulators of mitochondrial function: Role in cancer suppression","volume":"1840","author":"Tomasetti","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-215434_ref112","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature07823","article-title":"c-Myc suppression of miR-23a\/b enhances mitochondrial glutaminase expression and glutamine metabolism","volume":"458","author":"Gao","year":"2009","journal-title":"Nature"},{"key":"10.3233\/JAD-215434_ref113","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1016\/j.bmc.2007.04.071","article-title":"Characterized mechanism of \u03b1-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells","volume":"15","author":"Nakagawa","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.3233\/JAD-215434_ref114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2013.05.001","article-title":"The role of microRNAs in mitochondria in cancer","volume":"336","author":"Bienertova-Vasku","year":"2013","journal-title":"Cancer Lett"},{"key":"10.3233\/JAD-215434_ref115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1155\/2017\/2872156","article-title":"microRNA regulation of oxidative stress","volume":"2017","author":"Banerjee","year":"2017","journal-title":"Oxid Med Cell Longevity"},{"key":"10.3233\/JAD-215434_ref116","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jinorgbio.2007.06.004","article-title":"Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells","volume":"101","author":"Lukiw","year":"2007","journal-title":"J Inorg Biochem"},{"key":"10.3233\/JAD-215434_ref117","doi-asserted-by":"crossref","first-page":"4968321","DOI":"10.1155\/2018\/4968321","article-title":"From oxidative stress damage to pathways, networks, and autophagy via microRNAs","volume":"2018","author":"Engedal","year":"2018","journal-title":"Oxid Med Cell Longevity"},{"key":"10.3233\/JAD-215434_ref118","doi-asserted-by":"crossref","first-page":"16945","DOI":"10.3390\/ijms131216945","article-title":"Oxidative stress mediated-alterations of the microRNAexpression profile in mouse hippocampal neurons","volume":"13","author":"Xu","year":"2012","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-215434_ref119","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2017\/2398696","article-title":"microRNA regulation of oxidative stress-induced cellular senescence","volume":"2017","author":"Bu","year":"2017","journal-title":"Oxid Med Cell Longevity"},{"key":"10.3233\/JAD-215434_ref120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/ncrna5010020","article-title":"microRNA in brain pathology: Neurodegeneration the other side of the brain cancer","volume":"5","author":"Godlewski","year":"2019","journal-title":"Non-Coding RNA"},{"key":"10.3233\/JAD-215434_ref121","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/CIA.S285689","article-title":"Molecular changes in circulating microRNAs\u2019 expression and oxidative stress in adults with mild cognitive impairment: A biochemical and molecular study","volume":"16","author":"Al-Rawaf","year":"2021","journal-title":"Clin Interven Aging"},{"key":"10.3233\/JAD-215434_ref122","first-page":"4179","article-title":"Overexpression of miR-153 promotes oxidative stress in MPP(+)-induced PD model by negatively regulating the Nrf2\/HO-1 signaling pathway","volume":"11","author":"Zhu","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"10.3233\/JAD-215434_ref123","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mcn.2015.07.004","article-title":"microRNA-Let-7a regulates the function of microglia in inflammation","volume":"68","author":"Cho","year":"2015","journal-title":"Mol Cell Neurosci"},{"key":"10.3233\/JAD-215434_ref124","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3892\/etm.2020.9288","article-title":"miR-132 improves the cognitive function of rats with Alzheimer\u2019s disease by inhibiting the MAPK1 signal pathway","volume":"20","author":"Deng","year":"2020","journal-title":"Exper Ther Med"},{"key":"10.3233\/JAD-215434_ref125","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fphar.2018.00478","article-title":"microRNA-146a: A comprehensive indicator of inflammation and oxidative stress status induced in the brain of chronic T2DM rats","volume":"9","author":"Xie","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.3233\/JAD-215434_ref126","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1159\/000430122","article-title":"Hydrogen suppresses hypoxia\/reoxygenation-induced cell death in hippocampal neurons through reducing oxidative stress","volume":"36","author":"Wei","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.3233\/JAD-215434_ref127","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/brain\/aws047","article-title":"microRNA 486 is a potentially novel target for the treatment of spinal cord injury","volume":"135","author":"Jee","year":"2012","journal-title":"Brain"},{"key":"10.3233\/JAD-215434_ref128","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.canlet.2014.04.012","article-title":"Regulation of miR-23b expression and its dual role on ROS production and tumour development","volume":"349","author":"Donadelli","year":"2014","journal-title":"Cancer Lett"},{"key":"10.3233\/JAD-215434_ref129","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.20.04179-8"},{"key":"10.3233\/JAD-215434_ref130","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1093\/hmg\/ddr330","article-title":"microRNA-132 loss is associatedwith tau exon 10 inclusion in progressive supranuclear palsy","volume":"20","author":"Smith","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.3233\/JAD-215434_ref131","doi-asserted-by":"crossref","first-page":"9936","DOI":"10.1002\/jcb.28276","article-title":"miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3\u03b2 in Alzheimer\u2019s disease","volume":"120","author":"Li","year":"2019","journal-title":"J Cell Biochem"},{"key":"10.3233\/JAD-215434_ref132","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bbrc.2017.11.122","article-title":"Cerebrospinal fluid CD4+ T lymphocyte-derived miRNA-let-7b can enhances the diagnostic performance of Alzheimer\u2019s disease biomarkers","volume":"495","author":"Liu","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-215434_ref133","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bbrc.2016.08.037","article-title":"miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer\u2019s disease","volume":"478","author":"Liu","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-215434_ref134","doi-asserted-by":"crossref","first-page":"8286","DOI":"10.18632\/oncotarget.3221","article-title":"miR-93 promotes cell proliferation in gliomas through activation of PI3K\/Akt signaling pathway","volume":"6","author":"Jiang","year":"2015","journal-title":"Oncotarget"},{"key":"10.3233\/JAD-215434_ref135","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1096\/fj.06-5721fje","article-title":"Tumor suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules","volume":"20","author":"Zhang","year":"2006","journal-title":"FASEB J"},{"key":"10.3233\/JAD-215434_ref136","doi-asserted-by":"crossref","first-page":"26697","DOI":"10.1038\/srep26697","article-title":"microRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer\u2019s disease","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-215434_ref137","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.12659\/MSM.905064","article-title":"Genome-wide profiling of miRNA and mRNA expression in Alzheimer\u2019s disease","volume":"23","author":"Chang","year":"2017","journal-title":"Med Sci Monit"},{"key":"10.3233\/JAD-215434_ref138","first-page":"3959","article-title":"Genetic ablation of Dicer in adult forebrain neurons results inabnormal tau hyperphosphorylation and neurodegeneration","volume":"19","author":"H\u00e9bert","year":"2010","journal-title":"HumMol Genet"},{"key":"10.3233\/JAD-215434_ref139","first-page":"406561","article-title":"microRNAs and theregulation of tau metabolism","volume":"2012","author":"H\u00e9bert","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref140","doi-asserted-by":"crossref","first-page":"24314","DOI":"10.18632\/oncotarget.15149","article-title":"miR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K\/Akt\/GSK3\u03b2 pathway in N2a\/APP695swe cells","volume":"8","author":"Kang","year":"2017","journal-title":"Oncotarget"},{"key":"10.3233\/JAD-215434_ref141","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.15252\/embj.201387576","article-title":"microRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer\u2019s disease","volume":"33","author":"Banzhaf-Strathmann","year":"2014","journal-title":"EMBO J"},{"key":"10.3233\/JAD-215434_ref142","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ymthe.2017.01.018","article-title":"Targetingthe HDAC2\/HNF-4A\/miR-101b\/AMPK pathway rescues tauopathy anddendritic abnormalities in Alzheimer\u2019s disease","volume":"25","author":"Liu","year":"2017","journal-title":"Mol Ther"},{"key":"10.3233\/JAD-215434_ref143","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fneur.2017.00342","article-title":"The role of microRNAs in A\u03b2 deposition and tau phosphorylation in Alzheimer\u2019s disease","volume":"8","author":"Zhao","year":"2017","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-215434_ref144","doi-asserted-by":"crossref","first-page":"14645","DOI":"10.1523\/JNEUROSCI.1327-13.2013","article-title":"MiR-26b, upregulated in Alzheimer\u2019s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons","volume":"33","author":"Absalon","year":"2013","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref145","doi-asserted-by":"crossref","first-page":"134541","DOI":"10.1016\/j.neulet.2019.134541","article-title":"microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing","volume":"714","author":"Chaves","year":"2020","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-215434_ref146","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/jnc.12437","article-title":"Alternative polyadenylation and miR-34 family members regulate tau expression","volume":"127","author":"Dickson","year":"2013","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-215434_ref147","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/emboj.2011.327","article-title":"microRNA-34c is a novel target to treat dementias","volume":"30","author":"Zovoilis","year":"2011","journal-title":"EMBO J"},{"key":"10.3233\/JAD-215434_ref148","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1523\/JNEUROSCI.4660-08.2009","article-title":"The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule","volume":"29","author":"Carrettiero","year":"2009","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref149","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fnmol.2016.00140","article-title":"The protective role of microRNA-200c in Alzheimer\u2019s disease pathologies is induced by beta amyloid-triggered endoplasmic reticulum stress","volume":"9","author":"Wu","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"10.3233\/JAD-215434_ref150","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ijdevneu.2012.08.003","article-title":"Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model","volume":"30","author":"Chen","year":"2012","journal-title":"Int J Dev Neurosci"},{"key":"10.3233\/JAD-215434_ref151","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jcp.28988","article-title":"microRNA-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting VAV1 in Alzheimer\u2019s disease","volume":"235","author":"He","year":"2020","journal-title":"J Cell Physiol"},{"key":"10.3233\/JAD-215434_ref152","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.febslet.2015.02.001","article-title":"microRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha","volume":"589","author":"Wang","year":"2015","journal-title":"FEBS Lett"},{"key":"10.3233\/JAD-215434_ref153","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/cvr\/cvp015","article-title":"MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue","volume":"82","author":"Roy","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.3233\/JAD-215434_ref154","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4161\/cbt.24597","article-title":"microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells","volume":"14","author":"Comincini","year":"2013","journal-title":"Cancer Biol Ther"},{"key":"10.3233\/JAD-215434_ref155","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1080\/21691401.2019.1636805","article-title":"Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson\u2019s disease via regulating miR-100\/ATG10 axis and PI3K\/Akt\/mTOR pathway activation","volume":"47","author":"Peng","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10.3233\/JAD-215434_ref156","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s12031-015-0514-9","article-title":"miR137 regulates starvation-induced autophagy by targeting ATG7","volume":"56","author":"Zeng","year":"2015","journal-title":"J Mol Neurosci"},{"key":"10.3233\/JAD-215434_ref157","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/WNR.0000000000001494","article-title":"miR-132-5p regulates apoptosis and autophagy in MPTP model of Parkinson\u2019s disease by targeting ULK1","volume":"31","author":"Zhao","year":"2020","journal-title":"Neuroreport"},{"key":"10.3233\/JAD-215434_ref158","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13024-016-0121-4","article-title":"miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)","volume":"11","author":"Kim","year":"2016","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-215434_ref159","first-page":"2127","article-title":"miR-124 regulates cell apoptosis and autophagy in dopaminergic neurons and protects them by regulating AMPK\/mTOR pathway in Parkinson\u2019s disease","volume":"8","author":"Gong","year":"2016","journal-title":"Am J Transl Res"},{"key":"10.3233\/JAD-215434_ref160","doi-asserted-by":"crossref","first-page":"e0167096","DOI":"10.1371\/journal.pone.0167096","article-title":"The inhibition of microRNA-128 on IGF-1-activating mTOR signaling involves in temozolomide-induced glioma cell apoptotic death","volume":"11","author":"Chen","year":"2016","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref161","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neulet.2018.03.041","article-title":"miR-181b regulates autophagy in a model of Parkinson\u2019s disease by targeting the PTEN\/Akt\/mTOR signaling pathway","volume":"675","author":"Li","year":"2018","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-215434_ref162","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fnmol.2017.00068","article-title":"Combination of endothelial-monocyte-activating polypeptide-II with temozolomide suppress malignant biological behaviors of human glioblastoma stem cells via miR-590-3p\/MACC1 inhibiting PI3K\/AKT\/mTOR signal pathway","volume":"10","author":"Zhou","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.3233\/JAD-215434_ref163","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1080\/15384101.2016.1158360","article-title":"microRNA-496 - A new, potentially aging-relevant regulator of mTOR","volume":"15","author":"Rubie","year":"2016","journal-title":"Cell Cycle"},{"key":"10.3233\/JAD-215434_ref164","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbr.2016.09.020","article-title":"miR-23b improves cognitive impairments in traumatic brain injury by targeting ATG12-mediated neuronal autophagy","volume":"340","author":"Sun","year":"2018","journal-title":"Behav Brain Res"},{"key":"10.3233\/JAD-215434_ref165","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuro.2016.07.004","article-title":"miR-214-3p attenuates cognition defects via the inhibition ofautophagy in SAMP8 mouse model of sporadic Alzheimer\u2019s disease","volume":"56","author":"Zhang","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.3233\/JAD-215434_ref166","doi-asserted-by":"crossref","first-page":"24566","DOI":"10.1038\/srep24566","article-title":"MiR-299-5p regulates apoptosis through autophagy in neurons and ameliorates cognitive capacity in APPswe\/PS1dE9 mice","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-215434_ref167","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4103\/1673-5374.143439","article-title":"microRNA-9 promotes the neuronal differentiation of rat bone marrow mesenchymal stem cells by activating autophagy","volume":"10","author":"Zhang","year":"2015","journal-title":"Neural Regener Res"},{"key":"10.3233\/JAD-215434_ref168","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fnmol.2017.00160","article-title":"Downregulation of microRNA-193b-3p promotes autophagy and cell survival by targeting TSC1\/mTOR signaling in NSC-34 cells","volume":"10","author":"Li","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.3233\/JAD-215434_ref169","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s13311-019-00753-0","article-title":"Activation of the miR-34a-mediated SIRT1\/mTOR signaling pathway by urolithin A attenuates d-galactose-induced brain aging in mice","volume":"16","author":"Chen","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.3233\/JAD-215434_ref170","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.celrep.2015.08.028","article-title":"miR-199a links MeCP2 with mTOR signaling and its dysregulation leads to Rett Syndrome phenotypes","volume":"12","author":"Tsujimura","year":"2015","journal-title":"Cell Rep"},{"key":"10.3233\/JAD-215434_ref171","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/cn500149w","article-title":"Deciphering the function and regulation of microRNAs in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"5","author":"Qiu","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"10.3233\/JAD-215434_ref172","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.cellsig.2012.07.001","article-title":"miR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts","volume":"24","author":"Wu","year":"2012","journal-title":"Cell Signalling"},{"key":"10.3233\/JAD-215434_ref173","doi-asserted-by":"crossref","first-page":"2709053","DOI":"10.1155\/2017\/2709053","article-title":"microRNA-93 regulates hypoxia-induced autophagy by targeting ULK1","volume":"2017","author":"Li","year":"2017","journal-title":"Oxid Med Cell Longevity"},{"key":"10.3233\/JAD-215434_ref174","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fneur.2020.00288","article-title":"The regulation of microRNAs in Alzheimer\u2019s disease","volume":"11","author":"Kou","year":"2020","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-215434_ref175","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12935-017-0500-0","article-title":"microRNA 200c-3p regulates autophagy via upregulation of endoplasmic reticulum stress in PC-3 cells","volume":"18","author":"Sohn","year":"2018","journal-title":"Cancer Cell Int"},{"key":"10.3233\/JAD-215434_ref176","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.jid.2018.02.002","article-title":"microRNAs-103\/107 regulate autophagy in the epidermis","volume":"138","author":"Wang","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.3233\/JAD-215434_ref177","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.18632\/oncotarget.6732","article-title":"miR-183 regulates autophagy andapoptosis in colorectal cancer through targeting of UVRAG","volume":"7","author":"Huangfu","year":"2016","journal-title":"Oncotarget"},{"key":"10.3233\/JAD-215434_ref178","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1038\/emboj.2011.331","article-title":"microRNA-101 is a potent inhibitor of autophagy","volume":"30","author":"Frankel","year":"2011","journal-title":"EMBO J"},{"key":"10.3233\/JAD-215434_ref179","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.conb.2017.02.014","article-title":"miRNAs in synapse development and synaptic plasticity","volume":"45","author":"Hu","year":"2017","journal-title":"Curr Opin Neurobiol"},{"key":"10.3233\/JAD-215434_ref180","doi-asserted-by":"crossref","first-page":"e46189","DOI":"10.1371\/journal.pone.0046189","article-title":"miRNA regulons associated with synaptic function","volume":"7","author":"Paschou","year":"2012","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref181","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2012.01.036","article-title":"Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.3233\/JAD-215434_ref182","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3389\/fnsyn.2018.00019","article-title":"hsa-let-7c miRNA regulates synaptic and neuronal function in human neurons","volume":"10","author":"McGowan","year":"2018","journal-title":"Front Synaptic Neurosci"},{"key":"10.3233\/JAD-215434_ref183","doi-asserted-by":"crossref","first-page":"e28656","DOI":"10.1371\/journal.pone.0028656","article-title":"Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding","volume":"6","author":"Caputo","year":"2011","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref184","doi-asserted-by":"crossref","first-page":"e63648","DOI":"10.1371\/journal.pone.0063648","article-title":"Alterations of serum levels of BDNF-related miRNAs in patients with depression","volume":"8","author":"Li","year":"2013","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref185","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s41467-020-14761-8","article-title":"The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells","volume":"11","author":"McNeill","year":"2020","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-215434_ref186","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fneur.2019.00028","article-title":"microRNA-34a (miRNA-34a) mediated down-regulation of the post-synaptic cytoskeletal element SHANK3 in sporadic Alzheimer\u2019s disease (AD)","volume":"10","author":"Zhao","year":"2019","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-215434_ref187","first-page":"578","article-title":"MicroRNA in schizophrenia: Genetic and expression analysis of miR-130b (22q11)","volume":"72","author":"Burmistrova","year":"2007","journal-title":"Biochemistry"},{"key":"10.3233\/JAD-215434_ref188","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ebiom.2018.11.059","article-title":"A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer\u2019s disease","volume":"39","author":"Song","year":"2019","journal-title":"EBioMedicine"},{"key":"10.3233\/JAD-215434_ref189","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13195-019-0501-4","article-title":"AlteredmicroRNAs related to synaptic function as potential plasmabiomarkers for Alzheimer\u2019s disease","volume":"11","author":"Siedlecki-Wullich","year":"2019","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-215434_ref190","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10571-017-0486-0","article-title":"NCAM1 is the target of miRNA-572: Validation in the human oligodendroglial cell line","volume":"38","author":"Mancuso","year":"2018","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-215434_ref191","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/jnc.12236","article-title":"Progression in multiple sclerosis is associated with low endogenous NCAM","volume":"125","author":"Gnanapavan","year":"2013","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-215434_ref192","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1007\/s12035-020-01868-8","article-title":"Selected microRNAs increase synaptic resilience to the damaging binding of the Alzheimer\u2019s disease amyloid beta oligomers","volume":"57","author":"Zolochevska","year":"2020","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-215434_ref193","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.1523\/JNEUROSCI.0630-16.2016","article-title":"The brain-enriched microRNA miR-9-3p regulates synaptic plasticity and memory","volume":"36","author":"Sim","year":"2016","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref194","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.3390\/ijms18071570","article-title":"Differential miR-346 and miR-582-3p expression in association with selected maternal and fetal complications","volume":"18","author":"Tsai","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-215434_ref195","doi-asserted-by":"crossref","first-page":"AWP329","DOI":"10.1161\/str.51.suppl_1.WP329","article-title":"Abstract WP329: The role of miR-34b\/c in global ischemic stroke","volume":"51","author":"Byun","year":"2020","journal-title":"Stroke"},{"key":"10.3233\/JAD-215434_ref196","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fncel.2015.00193","article-title":"An updated role of microRNA-124 in central nervous system disorders: A review","volume":"9","author":"Sun","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.3233\/JAD-215434_ref197","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nrn2763","article-title":"microRNAs at the synapse","volume":"10","author":"Schratt","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-215434_ref198","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1471-4159.2008.05413.x","article-title":"Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain","volume":"106","author":"Lugli","year":"2008","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-215434_ref199","doi-asserted-by":"crossref","first-page":"e0170407","DOI":"10.1371\/journal.pone.0170407","article-title":"microRNAs, miR-23a-3p and miR-151-3p, are regulated in dentate gyrus neuropil following induction of long-term potentiation in vivo","volume":"12","author":"Ryan","year":"2017","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref200","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1007\/s12035-019-1492-7","article-title":"Neurite-enriched microRNA-218 stimulates translation of the GluA2 subunit and increases excitatory synaptic strength","volume":"56","author":"Rocchi","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-215434_ref201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2017.12.011","article-title":"microRNA-16 targets mRNA involved in neurite extension and branching in hippocampal neurons during presymptomatic prion disease","volume":"112","author":"Burak","year":"2018","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-215434_ref202","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1111\/j.1460-9568.2012.08220.x","article-title":"microRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex","volume":"36","author":"Scott","year":"2012","journal-title":"Eur J Neurosci"},{"key":"10.3233\/JAD-215434_ref203","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1503\/jpn.130169","article-title":"BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice","volume":"39","author":"Yi","year":"2014","journal-title":"J Psychiatry Neurosci"},{"key":"10.3233\/JAD-215434_ref204","doi-asserted-by":"crossref","first-page":"e41688","DOI":"10.1371\/journal.pone.0041688","article-title":"microRNA regulation of the synaptic plasticity-related gene Arc","volume":"7","author":"Wibrand","year":"2012","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref205","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/npp.2010.250","article-title":"Regulation of MiR-124, Let-7d, and MiR-181a in the accumbens affects the expression, extinction, and reinstatement of cocaine-induced conditioned place preference","volume":"36","author":"Chandrasekar","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.3233\/JAD-215434_ref206","doi-asserted-by":"crossref","first-page":"e24682","DOI":"10.1371\/journal.pone.0024682","article-title":"NMDA mediated contextual conditioning changes miRNA expression","volume":"6","author":"Kye","year":"2011","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref207","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13041-016-0241-3","article-title":"Glycine confers neuroprotection through microRNA-301a\/PTEN signaling","volume":"9","author":"Chen","year":"2016","journal-title":"Mol Brain"},{"key":"10.3233\/JAD-215434_ref208","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1523\/JNEUROSCI.0600-12.2013","article-title":"Comprehensive expression analyses of neuralcell-type-specific miRNAs identify new determinants of thespecification and maintenance of neuronal phenotypes","volume":"33","author":"Jovi\u010di\u0107","year":"2013","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref209","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nature09271","article-title":"A novel pathway regulates memory and plasticity via SIRT1 and miR-134","volume":"466","author":"Gao","year":"2010","journal-title":"Nature"},{"key":"10.3233\/JAD-215434_ref210","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1101\/gad.209619.112","article-title":"MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration","volume":"27","author":"Liu","year":"2013","journal-title":"Genes Dev"},{"key":"10.3233\/JAD-215434_ref211","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1038\/ncomms10045","article-title":"microRNA miR124 is required for the expression of homeostatic synaptic plasticity","volume":"6","author":"Hou","year":"2015","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-215434_ref212","doi-asserted-by":"crossref","first-page":"e62509","DOI":"10.1371\/journal.pone.0062509","article-title":"miR-132\/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity","volume":"8","author":"Remenyi","year":"2013","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref213","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1523\/JNEUROSCI.5210-12.2013","article-title":"Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p","volume":"33","author":"Chen","year":"2013","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref214","doi-asserted-by":"crossref","first-page":"18962","DOI":"10.1073\/pnas.1121288109","article-title":"microRNA-223 is neuroprotective by targeting glutamate receptors","volume":"109","author":"Harraz","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-215434_ref215","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuron.2010.01.005","article-title":"Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132","volume":"65","author":"Edbauer","year":"2010","journal-title":"Neuron"},{"key":"10.3233\/JAD-215434_ref216","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s13258-020-00940-w","article-title":"miRNAs-dependent regulation of synapse formation and function","volume":"42","author":"Song","year":"2020","journal-title":"Genes Genomics"},{"key":"10.3233\/JAD-215434_ref217","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.celrep.2015.05.040","article-title":"microRNA-137 controls AMPA-receptor-mediated transmission and mGluR-dependent LTD","volume":"11","author":"Olde Loohuis","year":"2015","journal-title":"Cell Rep"},{"key":"10.3233\/JAD-215434_ref218","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.molcel.2011.05.006","article-title":"Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling","volume":"42","author":"Muddashetty","year":"2011","journal-title":"Mol Cell"},{"key":"10.3233\/JAD-215434_ref219","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/acel.12444","article-title":"miR-204 downregulates EphB2 in aging mouse hippocampal neurons","volume":"15","author":"Mohammed","year":"2016","journal-title":"Aging Cell"},{"key":"10.3233\/JAD-215434_ref220","doi-asserted-by":"crossref","first-page":"e304","DOI":"10.1038\/tp.2013.77","article-title":"Opposing actions of environmental enrichment and Alzheimer\u2019s disease on the expression of hippocampal microRNAs in mouse models","volume":"3","author":"Barak","year":"2013","journal-title":"Transl Psychiatry"},{"key":"10.3233\/JAD-215434_ref221","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fnmol.2018.00388","article-title":"microRNA-210-5p contributes to cognitive impairment in early vascular dementia rat model through targeting Snap25","volume":"11","author":"Ren","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"10.3233\/JAD-215434_ref222","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12989-017-0215-3","article-title":"NF-\u03baB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM(2.5) aspiration","volume":"14","author":"Ku","year":"2017","journal-title":"Part Fibre Toxicol"},{"key":"10.3233\/JAD-215434_ref223","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/stem.1950","article-title":"Inhibition of miR-15a promotes BDNF expression and rescues dendritic maturation deficits in MeCP2-deficient neurons","volume":"33","author":"Gao","year":"2015","journal-title":"Stem Cells"},{"key":"10.3233\/JAD-215434_ref224","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12920-015-0083-3","article-title":"miR-10b-5p expression in Huntington\u2019s disease brain relates to age of onset and the extent of striatal involvement","volume":"8","author":"Hoss","year":"2015","journal-title":"BMC Med Genomics"},{"key":"10.3233\/JAD-215434_ref225","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1007\/s00018-014-1628-x","article-title":"miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF","volume":"71","author":"Varendi","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.3233\/JAD-215434_ref226","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1093\/hmg\/ddn201","article-title":"A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex","volume":"17","author":"Mellios","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.3233\/JAD-215434_ref227","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1038\/s41380-020-0824-3","article-title":"microRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer\u2019s disease pathogenesis","volume":"26","author":"Cao","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.3233\/JAD-215434_ref228","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12964-018-0303-5","article-title":"Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes","volume":"16","author":"Duan","year":"2018","journal-title":"Cell Commun Signaling"},{"key":"10.3233\/JAD-215434_ref229","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/ncrna5020035","article-title":"microRNAs in neuroinflammation: Implications in disease pathogenesis, biomarker discovery and therapeutic applications","volume":"5","author":"Slota","year":"2019","journal-title":"Non-coding RNA"},{"key":"10.3233\/JAD-215434_ref230","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.4049\/jimmunol.1202496","article-title":"microRNA let-7c regulates macrophage polarization","volume":"190","author":"Banerjee","year":"2013","journal-title":"J Immunol"},{"key":"10.3233\/JAD-215434_ref231","first-page":"5416","article-title":"Over-expressed miR-27a-3p inhibits inflammatory response to spinal cord injury by decreasing TLR4","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.3233\/JAD-215434_ref232","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/pathogens8040268","article-title":"Decrease of miR-19b-3p in brain microvascular endothelial cells attenuates meningitic Escherichia coli-induced neuroinflammation via TNFAIP3-mediated NF-\u03baB inhibition","volume":"8","author":"Amjad","year":"2019","journal-title":"Pathogens"},{"key":"10.3233\/JAD-215434_ref233","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12264-017-0153-y","article-title":"miR-30a positively regulates the inflammatory response of microglia in experimental autoimmune encephalomyelitis","volume":"33","author":"Fang","year":"2017","journal-title":"Neurosci Bull"},{"key":"10.3233\/JAD-215434_ref234","doi-asserted-by":"crossref","first-page":"e105421","DOI":"10.1371\/journal.pone.0105421","article-title":"A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected]","volume":"9","author":"Miyazaki","year":"2014","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref235","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1523\/JNEUROSCI.0851-16.2016","article-title":"miR-142-3p is a key regulator of IL-1\u03b2-dependent synaptopathy in neuroinflammation","volume":"37","author":"Mandolesi","year":"2017","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref236","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.4049\/jimmunol.1103171","article-title":"miR-29ab1 deficiency identifies a negativefeedback loop controlling Th1 bias that is dysregulated in multiplesclerosis","volume":"189","author":"Smith","year":"2012","journal-title":"J Immunol"},{"key":"10.3233\/JAD-215434_ref237","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1038\/ncomms5386","article-title":"miR-9 promotes microglial activation by targeting MCPIP1","volume":"5","author":"Yao","year":"2014","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-215434_ref238","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/cdd.2015.153","article-title":"microRNA-125b regulates microglia activationand motor neuron death in ALS","volume":"23","author":"Parisi","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.3233\/JAD-215434_ref239","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.4049\/jimmunol.1701448","article-title":"microRNA-27b modulates inflammatory response and apoptosis during Mycobacterium tuberculosis infection","volume":"200","author":"Liang","year":"2018","journal-title":"J Immunol"},{"key":"10.3233\/JAD-215434_ref240","doi-asserted-by":"crossref","first-page":"e30832","DOI":"10.1371\/journal.pone.0030832","article-title":"microRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state","volume":"7","author":"Saba","year":"2012","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref241","doi-asserted-by":"crossref","first-page":"35428","DOI":"10.1074\/jbc.M112.426866","article-title":"miR-125a-5p regulates differential activation of macrophages and inflammation","volume":"288","author":"Banerjee","year":"2013","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-215434_ref242","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4062\/biomolther.2018.073","article-title":"Inhibition of microRNA-15a\/16 expression alleviates neuropathic pain development through upregulation of G protein-coupled receptor kinase 2","volume":"27","author":"Li","year":"2019","journal-title":"Biomol Ther (Seoul)"},{"key":"10.3233\/JAD-215434_ref243","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.expneurol.2009.06.015","article-title":"Altered microRNA expression following traumatic spinal cord injury","volume":"219","author":"Liu","year":"2009","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-215434_ref244","doi-asserted-by":"crossref","first-page":"8986","DOI":"10.1111\/jcmm.15532","article-title":"miR-101 promotes pain hypersensitivity in rats with chronic constriction injury via the MKP-1 mediated MAPK pathway","volume":"24","author":"Qiu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.3233\/JAD-215434_ref245","first-page":"5003","article-title":"microRNA-148a regulates inflammation in microglia induced by oxygen-glucose deprivation via MAPK pathways","volume":"12","author":"Wang","year":"2019","journal-title":"Int J Clin Exp Med"},{"key":"10.3233\/JAD-215434_ref246","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/glia.22483","article-title":"Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes","volume":"61","author":"Hutchison","year":"2013","journal-title":"Glia"},{"key":"10.3233\/JAD-215434_ref247","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12974-016-0527-5","article-title":"Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation","volume":"13","author":"Dong","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.3233\/JAD-215434_ref248","doi-asserted-by":"crossref","first-page":"10873","DOI":"10.18632\/aging.103301","article-title":"miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke","volume":"12","author":"Tian","year":"2020","journal-title":"Aging"},{"key":"10.3233\/JAD-215434_ref249","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00441-011-1263-x","article-title":"microRNA-143 expression in dorsal root ganglion neurons","volume":"346","author":"Tam Tam","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.3233\/JAD-215434_ref250","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4049\/jimmunol.1301397","article-title":"The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf","volume":"192","author":"Su","year":"2014","journal-title":"J Immunol"},{"key":"10.3233\/JAD-215434_ref251","doi-asserted-by":"crossref","first-page":"105887","DOI":"10.1016\/j.intimp.2019.105887","article-title":"microRNA-23b alleviates neuroinflammation and brain injury in intracerebral hemorrhage by targeting inositol polyphosphate multikinase","volume":"76","author":"Hu","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.3233\/JAD-215434_ref252","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainresbull.2020.12.020","article-title":"microRNA-139-5p alleviates neurological deficit in hypoxic-ischemic brain damage via HDAC4 depletion and BCL-2 activation","volume":"169","author":"Fei","year":"2021","journal-title":"Brain Res Bull"},{"key":"10.3233\/JAD-215434_ref253","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.3390\/ijms22094956","article-title":"Epigenetic regulation of neuroinflammation in Parkinson\u2019s disease","volume":"22","author":"Rasheed","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-215434_ref254","doi-asserted-by":"crossref","first-page":"fcaa234","DOI":"10.1093\/braincomms\/fcaa234","article-title":"Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: Data from humans and animal models","volume":"3","author":"Laliberte","year":"2021","journal-title":"Brain Commun"},{"key":"10.3233\/JAD-215434_ref255","doi-asserted-by":"crossref","first-page":"27007","DOI":"10.18632\/oncotarget.8875","article-title":"ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-\u03baB and c-Myc to reduce breast cancer proliferation","volume":"7","author":"Yuan","year":"2016","journal-title":"Oncotarget"},{"key":"10.3233\/JAD-215434_ref256","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1523\/JNEUROSCI.1402-13.2013","article-title":"Changes in brain function occur years before the onset of cognitive impairment","volume":"33","author":"Beason-Held","year":"2013","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-215434_ref257","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbadis.2009.10.006","article-title":"Mitochondrial dysfunction is a trigger of Alzheimer\u2019s disease pathophysiology","volume":"1802","author":"Moreira","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-215434_ref258","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-215434_ref259","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fncel.2016.00024","article-title":"Alterations in mitochondrial quality control in Alzheimer\u2019s disease","volume":"10","author":"Cai","year":"2016","journal-title":"Front Cell Neurosci"},{"key":"10.3233\/JAD-215434_ref260","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nbd.2011.01.021","article-title":"Autophagy failure in Alzheimer\u2019s disease-locating the primary defect","volume":"43","author":"Nixon","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-215434_ref261","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3233\/JAD-201068","article-title":"Fluid biomarkers in clinical trials for Alzheimer\u2019s disease: Current and future application","volume":"81","author":"Yang","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref262","doi-asserted-by":"crossref","first-page":"590","DOI":"10.18632\/aging.100486","article-title":"Plasma microRNA biomarkers for detection of mild cognitive impairment","volume":"4","author":"Sheinerman","year":"2012","journal-title":"Aging"},{"key":"10.3233\/JAD-215434_ref263","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neurobiolaging.2013.07.005","article-title":"microRNAs in Alzheimer\u2019s disease: Differential expression in hippocampus and cell-free cerebrospinal fluid","volume":"35","author":"M\u00fcller","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-215434_ref264","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1021\/es400615q","article-title":"Copper-induced deregulation of microRNA expression in the zebrafish olfactory system","volume":"47","author":"Wang","year":"2013","journal-title":"Environ Sci Technol"},{"key":"10.3233\/JAD-215434_ref265","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-130932","article-title":"microRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer\u2019s disease","volume":"39","author":"Kiko","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref266","first-page":"263","article-title":"microRNA expression in Alzheimer blood mononuclear cells","volume":"1","author":"Schipper","year":"2007","journal-title":"Gene Reg Syst Biol"},{"key":"10.3233\/JAD-215434_ref267","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-010-0756-0","article-title":"Patterns of microRNA expression in normal and early Alzheimer\u2019s disease human temporal cortex: White matter versus gray matter","volume":"121","author":"Wang","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-215434_ref268","first-page":"6760","article-title":"microRNA-34a negatively regulates anesthesia-induced hippocampal apoptosis and memory impairment through FGFR1","volume":"7","author":"Jiang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.3233\/JAD-215434_ref269","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jinorgbio.2013.05.010","article-title":"Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line","volume":"128","author":"Alexandrov","year":"2013","journal-title":"J Inorg Biochem"},{"key":"10.3233\/JAD-215434_ref270","doi-asserted-by":"crossref","first-page":"e94839","DOI":"10.1371\/journal.pone.0094839","article-title":"Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer\u2019s and Parkinson\u2019s diseases correlate with disease status and features of pathology","volume":"9","author":"Burgos","year":"2014","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref271","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12031-017-0971-4","article-title":"microRNA expression in the locus coeruleus, entorhinal cortex, andhippocampus at early and middle stages of Braak neurofibrillarytangle pathology","volume":"63","author":"Llorens","year":"2017","journal-title":"J Mol Neurosci"},{"key":"10.3233\/JAD-215434_ref272","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/00207454.2014.919915","article-title":"The role of miR-124 in modulating hippocampal neurotoxicity induced by ketamine anesthesia","volume":"125","author":"Xu","year":"2015","journal-title":"Int J Neurosci"},{"key":"10.3233\/JAD-215434_ref273","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4137\/JEN.S32843","article-title":"Role of miRNA-9 in brain development","volume":"10","author":"Radhakrishnan","year":"2016","journal-title":"J Exp Neurosci"},{"key":"10.3233\/JAD-215434_ref274","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1007\/s12035-015-9605-4","article-title":"microRNA-9 mediates the cell apoptosis by targeting Bcl2l11 in ischemic stroke","volume":"53","author":"Wei","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-215434_ref275","doi-asserted-by":"crossref","first-page":"172351","DOI":"10.1155\/2013\/172351","article-title":"microRNAs as novel regulators of neuroinflammation","volume":"2013","author":"Ksiazek-Winiarek","year":"2013","journal-title":"Mediators Inflammation"},{"key":"10.3233\/JAD-215434_ref276","first-page":"365","article-title":"microRNA (miRNA) speciation in Alzheimer\u2019s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)","volume":"3","author":"Alexandrov","year":"2012","journal-title":"Int J Biochem Mol Biol"},{"key":"10.3233\/JAD-215434_ref277","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jns.2013.10.002","article-title":"Circulating miR-125b as a biomarker of Alzheimer\u2019s disease","volume":"336","author":"Tan","year":"2014","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-215434_ref278","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","article-title":"micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer\u2019s disease temporal lobe neocortex","volume":"459","author":"Sethi","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-215434_ref279","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/ALN.0000000000000345","article-title":"Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell-derived neurons","volume":"121","author":"Twaroski","year":"2014","journal-title":"Anesthesiology"},{"key":"10.3233\/JAD-215434_ref280","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fgene.2012.00077","article-title":"microRNAs and fetal brain development: Implications for ethanol teratology during the second trimester period of neurogenesis","volume":"3","author":"Miranda","year":"2012","journal-title":"Front Genet"},{"key":"10.3233\/JAD-215434_ref281","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1096\/fj.11-194464","article-title":"microRNAs control neurobehavioral development and function in zebrafish","volume":"26","author":"Tal","year":"2012","journal-title":"FASEB J"},{"key":"10.3233\/JAD-215434_ref282","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1080\/03601234.2010.502435","article-title":"Effect of triazophos, fipronil and their mixture on miRNA expression in adult zebrafish","volume":"45","author":"Wang","year":"2010","journal-title":"J Environ Sci Health B"},{"key":"10.3233\/JAD-215434_ref283","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4137\/BMI.S25132","article-title":"microRNA-seq data analysis pipeline to identify blood biomarkers for Alzheimer\u2019s disease from public data","volume":"10","author":"Satoh","year":"2015","journal-title":"Biomark Insights"},{"key":"10.3233\/JAD-215434_ref284","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1074\/jbc.M507378200","article-title":"Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid \u03b2-peptide-induced neuronal apoptosis: Synergistic involvement of calpain and caspase-3","volume":"281","author":"Fifre","year":"2006","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-215434_ref285","doi-asserted-by":"crossref","DOI":"10.1177\/1559325818761681","article-title":"Detrimental effects of paraquat on astrocytes-regulating synaptic functions","volume":"16","author":"Li","year":"2018","journal-title":"Dose Response"},{"key":"10.3233\/JAD-215434_ref286","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3389\/fncel.2019.00559","article-title":"Species-specific miRNAs in human brain development and disease","volume":"13","author":"Prodromidou","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.3233\/JAD-215434_ref287","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/gb-2013-14-7-r78","article-title":"A blood based 12-miRNA signature of Alzheimer disease patients","volume":"14","author":"Leidinger","year":"2013","journal-title":"Genome Biol"},{"key":"10.3233\/JAD-215434_ref288","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3233\/JAD-132144","article-title":"Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer\u2019s disease","volume":"40","author":"Tan","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref289","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3233\/JAD-170343","article-title":"A 9-microRNA signature in serum serves as a noninvasive biomarker in early diagnosis of Alzheimer\u2019s disease","volume":"60","author":"Guo","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-215434_ref290","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/00207454.2016.1209754","article-title":"An overview of circulating cell-free microRNAs as putative biomarkers in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"127","author":"Batistela","year":"2017","journal-title":"Int J Neurosci"},{"key":"10.3233\/JAD-215434_ref291","doi-asserted-by":"crossref","first-page":"16122","DOI":"10.18632\/oncotarget.15109","article-title":"Profile of 6 microRNA in blood plasma distinguish early stageAlzheimer\u2019s disease patients from non-demented subjects","volume":"8","author":"Nagaraj","year":"2017","journal-title":"Oncotarget"},{"key":"10.3233\/JAD-215434_ref292","doi-asserted-by":"crossref","first-page":"e69807","DOI":"10.1371\/journal.pone.0069807","article-title":"Circulating miRNA biomarkers for Alzheimer\u2019s disease","volume":"8","author":"Kumar","year":"2013","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref293","doi-asserted-by":"crossref","first-page":"e0167969","DOI":"10.1371\/journal.pone.0167969","article-title":"Stability of circulating blood-based microRNAs - pre-analytic methodological considerations","volume":"12","author":"Glinge","year":"2017","journal-title":"PloS One"},{"key":"10.3233\/JAD-215434_ref294","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadicAlzheimer\u2019s disease correlates with increased BACE1\/beta-secretaseexpression","volume":"105","author":"H\u00e9bert","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-215434_ref295","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.expneurol.2011.11.026","article-title":"Blood serum miRNA: Non-invasive biomarkers for Alzheimer\u2019s disease","volume":"235","author":"Geekiyanage","year":"2012","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-215434_ref296","first-page":"CD010783","article-title":"Mini-Mental State Examination (MMSE) for the detection ofAlzheimer\u2019s disease and other dementias in people with mildcognitive impairment (MCI)","volume":"2015","author":"Arevalo-Rodriguez","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-215434_ref297","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2296-9-29","article-title":"The accuracy of the MMSE in detecting cognitive impairment when administered by general practitioners: A prospective observational study","volume":"9","author":"Pezzotti","year":"2008","journal-title":"BMC Fam Pract"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-215434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:22Z","timestamp":1777370722000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-215434"}},"subtitle":[],"editor":[{"given":"Bakulski","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":296,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-215434","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]}}}