{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:56:02Z","timestamp":1777395362482,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:p>Background: Young-onset cognitive disorders (YOCD) often manifests with complex and atypical presentations due to underlying heterogenous pathologies. Therefore, a biomarker-based evaluation will allow for timely diagnosis and definitive management. Objective: Here, we evaluated the safety and usefulness of cerebrospinal fluid (CSF) sampling through lumbar puncture (LP) in YOCD patients in a tertiary clinical setting. Methods: Patients with mild cognitive impairment (MCI) and mild dementia with age of onset between 45-64 years were evaluated. Patients underwent magnetic resonance imaging and their medial temporal lobe atrophy (MTA) was rated. LP side-effects and the impact of the CSF findings on diagnosis and management were analyzed. Results: 142 patients (53 (37.32%) MCI, 51 (35.92%) dementia of the Alzheimer\u2019s disease [DAT] type, and 38 (26.76%) non-AD type dementia) who underwent LP between 2015 to 2021 were analyzed. Using post-LP results and MTA ratings, 74 (52.11%) patients met the AT(N) criteria for AD. 56 (39.44%) patients (28 out of 53 (50.0%) MCI, 12 out of 51 (21.43%) DAT, and 16 out of 38 (28.57%) non-AD dementia) had a change in diagnosis following LP. 13 (9.15%) patients developed side-effects post-LP (11 (84.62%) patients had headache, 1 (7.69%) patient had backache, and 1 (7.69%) patient had headache and backache). 32 (22.54%) patients had a change in management post-LP, 24 (75.0%) had medication changes, 10 (31.30%) had referrals to other specialists, and 3 (9.40%) was referred for clinical trial with disease modifying interventions. Conclusion: LP is well-tolerated in YOCD and can bring about relevant clinical decisions with regards to the diagnosis and management of this complex clinical condition.<\/jats:p>","DOI":"10.3233\/jad-215453","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T11:51:21Z","timestamp":1646999481000},"page":"479-488","source":"Crossref","is-referenced-by-count":5,"title":["Safety and Usefulness of Lumbar Puncture for the Diagnosis and Management of Young-Onset Cognitive Disorders"],"prefix":"10.1177","volume":"87","author":[{"given":"See Ann","family":"Soo","sequence":"first","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatin Zahra","family":"Zailan","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne Yi","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurveen Kaur","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Yi Xin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian Zhiyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline Su Lyn","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Jin","family":"Chiew","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok Pin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"},{"name":"Duke NUS Medical School, Singapore"},{"name":"Lee Kong Chian School of Medicine-NTU, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaendran","family":"Kandiah","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"},{"name":"Duke NUS Medical School, Singapore"},{"name":"Lee Kong Chian School of Medicine-NTU, 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