{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:49:06Z","timestamp":1790700546097,"version":"4.1.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,3,22]]},"abstract":"<jats:p>Background: Low-dose radiation therapy (LD-RT) has been shown to decrease amyloidosis or inflammation in systemic diseases and has recently been proposed as possible treatment of Alzheimer\u2019s disease (AD). A positive effect of LD-RT on tauopathy, the other marker of AD, has also been suggested. These effects have been shown in preclinical studies, but their mechanisms are still not well understood. Objective: This study aimed to evaluate if anti-amyloid and anti-inflammatory effects of LD-RT can be observed at an early stage of the disease. Its impact on tauopathy and behavioral alterations was also investigated. Methods: The whole brain of 12-month-old 3xTg-AD mice was irradiated with 10 Gy in 5 daily fractions of 2 Gy. Mice underwent behavioral tests before and 8 weeks post treatment. Amyloid load, tauopathy, and neuroinflammation were measured using histology and\/or ELISA. Results: Compared with wild-type animals, 3xTg-AD mice showed a moderate amyloid and tau pathology restricted to the hippocampus, a glial reactivity restricted to the proximity of amyloid plaques. LD-RT significantly reduced A\u03b242 aggregated forms (\u201371%) in the hippocampus and tended to reduce other forms in the hippocampus and frontal cortex but did not affect tauopathy or cognitive performance. A trend for neuroinflammation markers reduction was also observed. Conclusion: When applied at an early stage, LD-RT reduced amyloid load and possibly neuroinflammation markers, with no impact on tauopathy. The long-term persistence of these beneficial effects of LD-RT should be evaluated in future studies.<\/jats:p>","DOI":"10.3233\/jad-215510","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T13:49:54Z","timestamp":1643723394000},"page":"641-653","source":"Crossref","is-referenced-by-count":26,"title":["Low-Dose Radiation Therapy Reduces Amyloid Load in Young 3xTg-AD Mice"],"prefix":"10.1177","volume":"86","author":[{"given":"Kelly","family":"Ceyz\u00e9riat","sequence":"first","affiliation":[{"name":"Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland"},{"name":"Division of Nuclear Medicine and Molecular Imaging, Diagnostic Department, Geneva University Hospitals, and NimtLab, Faculty of Medicine, Geneva University, Geneva, Switzerland"},{"name":"Division of Radiation Oncology, Department of Oncology, Geneva University Hospitals, Geneva, Switzerland"},{"name":"Faculty of Medicine, Geneva University, 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