{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:10:24Z","timestamp":1779898224629,"version":"3.53.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In Alzheimer\u2019s disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)\/limbic regions, and those that spare MTL regions, can be visually identified using\n                      <jats:sup>18<\/jats:sup>\n                      F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Tau\n                      <jats:sup>18<\/jats:sup>\n                      F-MK6240 PET images of 151 amyloid-\u03b2 positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), MTL-sparing, and Typical by two readers. Groups were evaluated for differences in age, APOE \u025b4 carriage, hippocampal volumes, and cognition (MMSE, composite memory and non-memory scores). Voxel-wise contrasts were also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Visual rating resulted in 59.6% classified as Typical, 17.9% as MTL-sparing, 9.9% LP, and 12.6% as tau negative. Intra-rater and inter-rater reliability was strong (Cohen\u2019s kappa values of 0.89 and 0.86 respectively). Tracer retention in a \u201chook\u201d-like distribution on sagittal sequences was observed in the LP and Typical groups. The visually classified MTL-sparing group had lower APOE \u025b4 carriage and relatively preserved hippocampal volumes. Higher MTL tau was associated with greater amnestic cognitive impairment. High cortical tau was associated with greater impairments on non-memory domains of cognition, and individuals with high cortical tau were more likely to have dementia than MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Tau distribution patterns can be visually identified using\n                      <jats:sup>18<\/jats:sup>\n                      F-MK6240 PET and are associated with differences in APOE \u025b4 carriage, hippocampal volumes, and cognition.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-215558","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T11:12:45Z","timestamp":1657278765000},"page":"1627-1637","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Visually Identified Tau\n                    <sup>18<\/sup>\n                    F-MK6240 PET Patterns in Symptomatic Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"88","author":[{"given":"Natasha","family":"Krishnadas","sequence":"first","affiliation":[{"name":"Florey Department of Neurosciences & Mental Health, The University of Melbourne, Parkville, VIC, Australia"},{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"},{"name":"Health and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bourgeat","sequence":"additional","affiliation":[{"name":"Health and Biosecurity Flagship, The Australian eHealth Research Centre, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita M.Y.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia"},{"name":"National Ageing Research Institute, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Bozinovski","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha C.","family":"Burnham","sequence":"additional","affiliation":[{"name":"Health and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne S.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Florey Institute of Neurosciences & Mental Health, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Laws","sequence":"additional","affiliation":[{"name":"Centre for Precision Health, Edith Cowan University, Perth, WA, Australia"},{"name":"Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"Florey Institute of Neurosciences & Mental Health, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Florey Institute of Neurosciences & Mental Health, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"},{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Florey Department of Neurosciences & Mental Health, The University of Melbourne, Parkville, VIC, Australia"},{"name":"Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia"},{"name":"Florey Institute of Neurosciences & Mental Health, Parkville, VIC, 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