{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:28:27Z","timestamp":1792189707834,"version":"4.4.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:p>Background: Dementia is one of the top causes of death worldwide, but individuals with dementia and their caregivers report that knowing what to expect, including regarding approaching end of life, is an unmet need. Objective: To identify predictors of death in individuals with Alzheimer disease (AD) dementia, Lewy body dementia (LBD), vascular dementia, and frontotemporal dementia. Methods: The study used data from National Alzheimer\u2019s Coordinating Center participants with dementia and an etiologic diagnosis of AD, Lewy body disease, frontotemporal lobar degeneration (FTLD, with or without motor neuron disease), or vascular dementia. Analyses included median survival across dementia types and predictors of death at 5 years based on baseline demographics and clinical measure performance. Five-year survival probability tables were stratified by predictor values. Results: Individuals with AD had the longest survival (median 6 years), followed by FTLD (5 years), and vascular dementia and LBD (each 4 years). The strongest predictors of death for the full cohort were dementia type (higher risk with non-AD dementias), sex (higher risk with male sex), and race and ethnicity (higher risk with white and non-Hispanic participants). Age was associated with higher mortality risk across the non-Alzheimer dementias; other significant associations included worse cognitive status (FTLD, LBD) and more depression (LBD). Conclusion: Results can help clinicians counsel individuals with dementia and families regarding average dementia trajectories; findings regarding individual risk factors can aid individualizing expectations. Further research is needed to investigate drivers of mortality in the non-AD dementias to improve counseling and help identify potentially modifiable factors.<\/jats:p>","DOI":"10.3233\/jad-215587","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T13:54:44Z","timestamp":1646402084000},"page":"1935-1946","source":"Crossref","is-referenced-by-count":31,"title":["Predictors of Mortality in Individuals with Dementia in the National Alzheimer\u2019s Coordinating Center"],"prefix":"10.1177","volume":"86","author":[{"given":"Melissa J.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Departments of Neurology and Health Outcomes & Biomedical Informatics, University of Florida College of Medicine, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangchen","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Florida College of Public Health & Health Professions and College of Medicine, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Kurasz","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, University of Florida College of Public Health & Health Professions, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Florida College of Public Health & Health Professions and College of Medicine, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215587_ref2","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1212\/WNL.0000000000003917","article-title":"Quality improvement in neurology: Dementia management quality measurement set update","volume":"88","author":"Sanders","year":"2017","journal-title":"Neurology"},{"key":"10.3233\/JAD-215587_ref3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/jgs.15608","article-title":"Cause of death and end-of-life experiences in dementia with Lewy bodies","volume":"67","author":"Armstrong","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-215587_ref4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/jgs.13251","article-title":"Unmet needs of caregivers of individuals referred to a dementia care program","volume":"63","author":"Jennings","year":"2015","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-215587_ref5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1017\/S0959259810000092","article-title":"Approaching the end of life and dying with dementia in care homes: The accounts of family carers","volume":"20","author":"Hennings","year":"2010","journal-title":"Rev Clin Gerontol"},{"key":"10.3233\/JAD-215587_ref6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/WAD.0b013e3181c72b5d","article-title":"Lewy body dementia: Caregiver burden and unmet needs","volume":"24","author":"Galvin","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-215587_ref7","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/gps.4502","article-title":"The care needs and experiences with the use of services of people with young-onset dementia and their caregivers: A systematic review","volume":"31","author":"Millenaar","year":"2016","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-215587_ref8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1741-7015-11-105","article-title":"Caregivers\u2019 understanding of dementia predicts patients\u2019 comfort at death: A prospective observational study","volume":"11","author":"van der Steen","year":"2013","journal-title":"BMC Med"},{"key":"10.3233\/JAD-215587_ref10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/ageing\/afv143","article-title":"Dementia priority setting partnership with the James Lind Alliance: Using patient and public involvement to inform the research agenda","volume":"44","author":"Kelly","year":"2015","journal-title":"Age Ageing"},{"key":"10.3233\/JAD-215587_ref11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12904-017-0221-0","article-title":"Better palliative care for people with a dementia: Summary of interdisciplinary workshop highlighting current gaps and recommendations for future research","volume":"17","author":"Fox","year":"2017","journal-title":"BMC Palliat Care"},{"key":"10.3233\/JAD-215587_ref12","doi-asserted-by":"crossref","first-page":"e0137251","DOI":"10.1371\/journal.pone.0137251","article-title":"What are physicians\u2019 reasons for not referring people with life-limiting illnesses to specialist palliative care services? 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