{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:55:48Z","timestamp":1777395348694,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:p>Background: Although cigarette smoking is an important modifiable factor of cognitive impairment, the roles of the Alzheimer\u2019s disease (AD) core pathologies in modulating this process have not been fully delineated. Objective: This study aimed to explore associations of cigarette smoking with cognition and cerebrospinal fluid (CSF) AD biomarkers. Methods: A total of 1,079 non-demented participants were included from the Chinese Alzheimer\u2019s Biomarker and LifestylE (CABLE) study. Associations of cigarette smoking with cognition and CSF AD biomarkers were explored by multiple linear regression models. The mediation analyses with 10,000 bootstrapped iterations were conducted to explore the mediation effects. Results: Heavy cigarette smokers (pack-years\u200a&gt;\u200a20) had poorer global cognition as well as higher levels of CSF p-tau and t-tau compared with the non-smokers (p\u200a&lt;\u200a0.01). Time-dose effect analysis among smokers also suggested that both cognitive impairment and tau pathologies markedly deteriorated with greater cumulative cigarette exposure, independently of the A\u03b2 pathology (p\u200a&lt;\u200a0.01). In addition, smokers with older age or APOE \u025b4 showed more obvious influences on CSF tau pathologies but not on cognition. Overall, the influence of smoking on cognition was partially mediated by tau pathologies (estimated proportion: 12%), which still remained in late-life (10% \u223c11%) and increased in APOE \u025b4 carriers (18% \u223c24%). Encouragingly, long-term smoking cessation mitigated both cognitive impairment and tau pathologies (p\u200a&lt;\u200a0.05). Conclusion: Cigarette smoking was associated with both cognitive impairment and tau pathologies, which were accompanied by time-dose effects. Tau pathology might be a key mediator for influences of cigarette smoking on cognitive impairments.<\/jats:p>","DOI":"10.3233\/jad-215618","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T13:26:27Z","timestamp":1646141187000},"page":"1849-1859","source":"Crossref","is-referenced-by-count":9,"title":["Tau Pathologies Mediate the Association of Cigarette Smoking with Cognitive Impairment in Older Adults Without Dementia: The CABLE Study"],"prefix":"10.1177","volume":"86","author":[{"given":"Hao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ting","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weifang Medical University, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Lin","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"},{"name":"Department of Neurology, Weifang Medical 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