{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:03:52Z","timestamp":1791435832838,"version":"4.3.3"},"reference-count":62,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:p>Background: Depression is a common manifestation in Alzheimer\u2019s disease (AD). In clinical practice, antidepressant medication is often used for depression in AD. Objective: We explore the effectiveness of the atypical antidepressant tianeptine compared with other conventional antidepressants in AD patients with depression in a real-life setting. Methods: We retrospectively identified 126 AD patients who had received antidepressant treatment for 12 months with tianeptine or other antidepressants. Subjects were divided into two groups according to the treatment they had received: tianeptine group (n\u200a=\u200a38) or other antidepressant group (n\u200a=\u200a88). Drug effects on depression, cognition, behavior, and functional performance were evaluated at baseline, 6, and 12 months. A Mixed Effects Model Analysis was carried out to evaluate changes in performance scores. Results: Both tianeptine and other antidepressants showed an antidepressant effect after 12 months with significant improvement on the Cornell Scale for Depression in Dementia, the Hamilton Depression Rating Scale, and the Neuropsychiatric Inventory-Depression subscale. A statistically significant improvement at 12 months was shown in the tianeptine group versus the other antidepressants group on most of the cognitive measures such as the Mini-Mental State Examination, the Letter and Category Fluency Test, the Rey Auditory Verbal Learning Test, and the Boston Naming Test. Conclusion: Our results suggest that tianeptine reduces depressive symptoms and improves cognition in AD patients. This could be considered clinically relevant and should inspire the design of future long-term randomized controlled trials that contribute to supporting the use of tianeptine for improving cognitive function in AD patients.<\/jats:p>","DOI":"10.3233\/jad-215630","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T12:39:30Z","timestamp":1654605570000},"page":"707-720","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Tianeptine Treatment on Depression and Cognitive Function in Patients with Alzheimer\u2019s Disease: A 12-Month Retrospective Observational Study"],"prefix":"10.1177","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-6644","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Garc\u00eda-Alberca","sequence":"first","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Gris","sequence":"additional","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"de la Gu\u00eda","sequence":"additional","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-215630_ref1","first-page":"332","article-title":"Alzheimer\u2019s disease facts and figures","volume":"11","author":"Alzheimer\u2019s Association","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-215630_ref2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1176\/appi.ajp.158.1.68","article-title":"The specificity of depressive symptoms in patients with Alzheimer\u2019s disease","volume":"158","author":"Chemerinski","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.3233\/JAD-215630_ref3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archpsyc.60.7.737","article-title":"Treating depression in Alzheimer disease","volume":"60","author":"Lyketsos","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.3233\/JAD-215630_ref4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1176\/appi.ajp.160.5.857","article-title":"A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer\u2019s disease","volume":"160","author":"Zubenko","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.3233\/JAD-215630_ref5","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study","volume":"288","author":"Lyketsos","year":"2002","journal-title":"JAMA"},{"key":"10.3233\/JAD-215630_ref6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1440-1819.2009.01955.x","article-title":"Neuropsychiatric symptoms predict change in quality of life of Alzheimer disease patients: A two-year follow-up study","volume":"63","author":"Tatsumi","year":"2009","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.3233\/JAD-215630_ref7","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/00019442-200508000-00006","article-title":"Cognitive status, depressive symptoms, and health status as predictors of functional disability among elderly persons with low-to-moderate education: The Faenza Community Aging Study","volume":"13","author":"De Ronchi","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-215630_ref8","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1212\/01.WNL.0000036904.73393.E4","article-title":"The incremental direct costs associated with behavioral symptoms in AD","volume":"59","author":"Murman","year":"2002","journal-title":"Neurology"},{"key":"10.3233\/JAD-215630_ref9","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.archger.2010.05.004","article-title":"Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer\u2019s disease (AD)? 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