{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:56:56Z","timestamp":1793390216234,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,5,31]]},"abstract":"<jats:p>Plasma phosphorylated tau species have been recently proposed as peripheral markers of Alzheimer\u2019s disease (AD) pathology. In this cross-sectional study including 91 subjects, plasma and cerebrospinal fluid (CSF) p-tau181 and p-tau231 levels were elevated in the early symptomatic stages of AD. Plasma p-tau231 and p-tau181 were strongly related to CSF phosphorylated tau, total tau and amyloid and exhibited a high accuracy\u2014close to CSF p-tau231 and p-tau181\u2014to identify AD already in the early stage of the disease. The findings might support the use as diagnostic and prognostic peripheral AD biomarkers in both research and clinical settings.<\/jats:p>","DOI":"10.3233\/jad-215646","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:20:43Z","timestamp":1649157643000},"page":"991-997","source":"Crossref","is-referenced-by-count":30,"title":["Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"87","author":[{"given":"Andrea","family":"Pilotto","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Parigi","sequence":"additional","affiliation":[{"name":"A. 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