{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:59:21Z","timestamp":1777395561414,"version":"3.51.4"},"reference-count":89,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,6,28]]},"abstract":"<jats:p>Background: BOLD signals in the gray matter (GM) and white matter (WM) are tightly coupled. However, our understanding of the cross-tissue functional network in Alzheimer\u2019s disease (AD) is limited. Objective: We investigated the changes of cross-tissue functional connectivity (FC) metrics for the GM regions susceptible to AD damage. Methods: For each GM region in the default mode (DMN) and limbic networks, we obtained its low-order static FC with any WM region, and the high-order static FC between any two WM regions based on their FC pattern similarity with multiple GM regions. The dynamic and directional properties of cross-tissue FC were then acquired, specifically for the regional pairs whose low- or high-order static FCs showed significant differences between AD and normal control (NC). Moreover, these cross-tissue FC metrics were correlated with voxel-based GM volumes and MMSE in all participants. Results: Compared to NC, AD patients showed decreased low-order static FCs between the intra-hemispheric GM-WM pairs (right ITG-right fornix; left MoFG-left posterior corona radiata), and increased low-order static, dynamic, and directional FCs between the inter-hemispheric GM-WM pairs (right MTG-left superior\/posterior corona radiata). The high-order static and directional FCs between the left cingulate bundle-left tapetum were increased in AD, based on their FCs with the GMs of DMN. Those decreased and increased cross-tissue FC metrics in AD had opposite correlations with memory-related GM volumes and MMSE (positive for the decreased and negative for the increased). Conclusion: Cross-tissue FC metrics showed opposite changes in AD, possibly as useful neuroimaging biomarkers to reflect neurodegenerative and compensatory mechanisms.<\/jats:p>","DOI":"10.3233\/jad-215649","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T12:20:32Z","timestamp":1652185232000},"page":"273-290","source":"Crossref","is-referenced-by-count":2,"title":["Aberrant Cross-Tissue Functional Connectivity in Alzheimer\u2019s Disease: Static, Dynamic, and Directional Properties"],"prefix":"10.1177","volume":"88","author":[{"given":"Xingxing","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Brain Disorders and Cognitive Sciences, School of Psychology, Shenzhen University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Guan","sequence":"additional","affiliation":[{"name":"Center for Brain Disorders and Cognitive Sciences, School of Psychology, Shenzhen University, Shenzhen, China"},{"name":"Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, China"},{"name":"Center for Neuroimaging, Shenzhen Institute of Neuroscience, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjia","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Brain Disorders and Cognitive Sciences, School of Psychology, Shenzhen University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Brain Disorders and Cognitive Sciences, School of Psychology, Shenzhen University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanlin","family":"Zhu","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejia","family":"Luo","sequence":"additional","affiliation":[{"name":"Center for Brain Disorders and Cognitive Sciences, School of Psychology, Shenzhen University, Shenzhen, China"},{"name":"Research Center of Brain Science and Visual Cognition, Kunming University of Science and Technology, Kunming, China"},{"name":"College of Teacher Education, Qilu Normal University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Brain Disorders and Cognitive Sciences, School of Psychology, Shenzhen University, Shenzhen, China"},{"name":"Shenzhen-Hong 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